Apolipoprotein(a) inhibits lipopolysaccharide-induced IL-6 secretion in human astrocytoma cell line by interfering with lipopolysaccharide signaling

Chimienti, Guglielmina; Mezzapesa, Anna; Liuzzi, Grazia Maria; Latronico, Tiziana; Pèpe, G.

doi:10.1007/s00011-010-0272-7

Cited by 2 publications

(1 citation statement)

References 31 publications

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“… 36 , 39 Recent studies have demonstrated that lipid metabolism reprogramming is implicated in the involvement of cell growth, angiogenesis, signal transduction and progression of several cancers, 40 , 41 including glioma. 42 , 43 Moreover, Chimienti et al 44 reported that APOA inhibited the secretion of IL-6 by interfering with lipopolysaccharide signaling in a human astrocytoma cell line. Hashemi et al 45 discovered that APOA1 was a key oncogene in malignant astrocytoma tumors due to its functional consequences in tumor growth, angiogenesis and migration.…”

Section: Discussionmentioning

confidence: 99%

<p>Low Expression of APOB mRNA or Its Hypermethylation Predicts Favorable Overall Survival in Patients with Low-Grade Glioma</p>

Han

Chen

et al. 2020

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Background: This study was performed to explore the clinical and prognostic significance of APOB mRNA expression, DNA methylation and APOB mutation in patients with lowgrade glioma (LGG). Methods: Bioinformatic analysis was conducted using genomic, clinical and survival data from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases. Serum APOB protein levels were measured via immunoturbidimetry in 150 patients with LGG and 100 healthy controls from Hubei General Hospital. Results: There was a negative association between the levels of APOB mRNA and DNA methylation (r=−0.355, P<0.0001) in patients with LGG from the TCGA database. Additionally, LGG patients with low levels of APOB mRNA exhibited better overall survival (OS) than those with high levels of APOB mRNA (HR=0.637, P=0.0085). The survival time of LGG patients with APOB hypermethylation was markedly longer than that of patients with APOB hypomethylation (HR=0.423, P=0.0185). The prognostic significance of APOB mRNA and DNA methylation was also validated with the CGGA cohort, and a similar conclusion was reached. APOB gene mutations were observed in 3% of patients with LGG from the TCGA database, and no association was detected between APOB mutations and OS (P=0.164). Furthermore, the levels of APOB protein were much lower in patients with LGG than in normal individuals (P=0.0022), and the expression of APOB protein was markedly different among groups when stratified by histological type (P<0.0001) and histological-molecular classification (P<0.0001). Conclusion: APOB mRNA expression is negatively regulated by DNA methylation in patients with LGG. Low expression or hypermethylation of APOB might predict relatively favorable survival in patients with LGG.

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Section: Discussionmentioning

confidence: 99%

<p>Low Expression of APOB mRNA or Its Hypermethylation Predicts Favorable Overall Survival in Patients with Low-Grade Glioma</p>

Han

Chen

et al. 2020

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Minimally invasive diagnosis of Alzheimer’s disease by detecting microRNA using a quartz crystal resonator

Swarbrick¹

2019

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Apolipoprotein(a) inhibits lipopolysaccharide-induced IL-6 secretion in human astrocytoma cell line by interfering with lipopolysaccharide signaling

Abstract: Our data indicate that apo(a) plays a natural anti-endotoxin role which relies on its interference with cell-associated and serum components of LPS signaling.

Cited by 2 publications

References 31 publications

<p>Low Expression of APOB mRNA or Its Hypermethylation Predicts Favorable Overall Survival in Patients with Low-Grade Glioma</p>

<p>Low Expression of APOB mRNA or Its Hypermethylation Predicts Favorable Overall Survival in Patients with Low-Grade Glioma</p>

Minimally invasive diagnosis of Alzheimer’s disease by detecting microRNA using a quartz crystal resonator

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