Apolipoprotein B-100 kinetics in visceral obesity: Associations with plasma apolipoprotein C-III concentration

Chan, Dick C.; Watts, Gerald F.; Redgrave, Trevor G.; Mori, Trevor A.; Barrett, P. Hugh R.

doi:10.1053/meta.2002.33339

Cited by 130 publications

(145 citation statements)

References 26 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…Recent kinetic studies reported a close relationship between plasma or VLDL apoC-III and VLDL apoB kinetics in overweight or obese men (Chan et al, 2002;Cohn et al, 2004a). Chan et al (2002) reported that plasma concentrations of apoC-III were positively associated with VLDL apoB PR and inversely associated with VLDL apoB FCR.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels

Desroches

Deshaies

et al. 2007

Eur J Clin Nutr

View full text Add to dashboard Cite

Objective: To compare the effect of a high monounsaturated fatty acid (MUFA) diet and of a control low-fat diet consumed under ad libitum conditions on plasma apolipoprotein (apo) C-III metabolism. Design: Randomized, two-arm parallel dietary trial. Setting: Diets were prepared and consumed at the metabolic kitchen of the Department of Food Sciences and Nutrition, and laboratory analyses were performed at the Institute of Nutraceuticals and Functional Foods at Laval University. Subjects and interventions: Eighteen men were randomly assigned to either the high MUFA diet or the low-fat control diet, which they consumed for 6-7 weeks. Before and after the dietary intervention, subjects received a primed-constant infusion of [5,5,5-D 3 ]-L-leucine for 12 h under constant feeding conditions for the determination of plasma apoC-III kinetics. Results: The high-MUFA diet and the low-fat control diet had no significant impact on plasma apoC-III production rate (PR) or fractional catabolic rate. However, diet-induced variations in plasma apoCIII PR predicted the reduction in plasma triglycerides and apoC-III levels (r ¼ 0.85, Po0.01 and r ¼ 0.73, Po0.05, respectively) in the high MUFA group only. Conclusions: These results suggest that the hypotriglyceridemic effect of a high-MUFA diet may be attributable in part to a reduced hepatic production of apoC-III.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Chan et al (2002) reported that plasma concentrations of apoC-III were positively associated with VLDL apoB PR and inversely associated with VLDL apoB FCR. Results from Cohn et al indicated that plasma and VLDL apoC-III production were strongly correlated with the plasma concentration as well as production of VLDL-TG.…”

Section: Discussionmentioning

confidence: 99%

Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels

Desroches

Deshaies

et al. 2007

Eur J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…Many different factors contribute, including marked hormonal changes,2 changes in metabolic profile associated with increased risk of the metabolic syndrome,3 and relative increase in intra‐abdominal fat with age 4. Accumulation of intra‐abdominal fat is associated with increased waist circumference and liver fat,5 overproduction of very low‐density lipoprotein (VLDL), and decreased catabolism of apolipoprotein (apo)B‐containing particles in men 6. The catabolism of apoB‐containing particles is partly determined by plasma apoC‐III concentrations, and higher plasma apoC‐III has been associated with dyslipidemia in obese men 7.…”

Section: Introductionmentioning

confidence: 99%

Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women

Hodson

Banerjee

Rial

et al. 2015

JAHA

Self Cite

View full text Add to dashboard Cite

BackgroundAndroid fat distribution (abdominal obesity) is associated with insulin resistance, hepatic steatosis, and greater secretion of large very low‐density lipoprotein (VLDL) particles in men. Since abdominal obesity is becoming increasingly prevalent in women, we aimed to investigate the relationship between android fat and hepatic lipid metabolism in pre‐ and postmenopausal women.Methods and ResultsWe used a combination of stable isotope tracer techniques to investigate intrahepatic fatty acid synthesis and partitioning in 29 lean and 29 abdominally obese women (android fat/total fat 0.065 [0.02 to 0.08] and 0.095 [0.08 to 0.11], respectively). Thirty women were premenopausal aged 35 to 45 and they were matched for abdominal obesity with 28 postmenopausal women aged 55 to 65. As anticipated, abdominal obese women were more insulin resistant with enhanced hepatic secretion of large (404±30 versus 268±26 mg/kg lean mass, P<0.001) but not small VLDL (160±11 versus 142±13). However, postmenopausal status had a pronounced effect on the characteristics of small VLDL particles, which were considerably triglyceride‐enriched (production ratio of VLDL 2‐ triglyceride:apolipoprotein B 30±5.3 versus 19±1.6, P<0.05). In contrast to postmenopausal women, there was a tight control of hepatic fatty acid metabolism and triglyceride production in premenopausal women, whereby oxidation (r s=−0.49, P=0.006), de novo lipogenesis (r s=0.55, P=0.003), and desaturation (r s=0.48, P=0.012) were closely correlated with abdominal obesity‐driven large VLDL‐triglyceride secretion rate.ConclusionsIn women, abdominal obesity is a major driver of hepatic large VLDL particle secretion, whereas postmenopausal status was characterized by increased small VLDL particle size. These data provide a mechanistic basis for the hyperlipidemia observed in postmenopausal obesity.

show abstract

“…In the study by Chan et al (2002b), the plasma apoC-III concentration was significantly positively correlated with both the secretion rate of VLDL-apoB-100 and negatively with its conversion to LDL (r ¼ 0.51 and 0.41, respectively). The significance of these correlations lies in the fact that apoC-III, or a high ratio of apoC-III to that of apoC-II (the lipoprotein lipase activator), inhibits the action of lipoprotein lipase in the lipolysis of VLDL (Graziani et al, 1994).…”

Section: Tracer Kinetics Results For Apolipoproteinsmentioning

confidence: 91%

“…The plasma levels of VLDL remnants were increased in 48 men with visceral obesity who were also insulin resistant (Chan et al, 2002a). In the companion study (Chan et al, 2002b) compared to 10 lean controls, these subjects had elevated plasma levels of triglycerides, LDL-cholesterol, apoB-100 in VLDL, IDL, and LDL, and apolipoprotein C-III. In addition, insulin and lathosterol levels (a marker of cholesterol synthesis) were increased.…”

Section: Tracer Kinetics Results For Apolipoproteinsmentioning

confidence: 91%

Stable isotopes in obesity research

Dolnikowski

Marsh

Das

et al. 2004

Mass Spectrometry Reviews

View full text Add to dashboard Cite

Obesity is recognized as a major public health problem. Obesity is a multifactorial disease and is often associated with a wide range of comorbidities including hypertension, non-insulin dependent (Type II) diabetes mellitus, and cardiovascular disease, all of which contribute to morbidity and mortality. This review deals with stable isotope mass spectrometric methods and the application of stable isotopes to metabolic studies of obesity. Body composition and total energy expenditure (TEE) can be measured by mass spectrometry using stable isotope labeled water, and the metabolism of protein, lipid, and carbohydrate can be measured using appropriate labeled tracer molecules.

show abstract

Apolipoprotein B-100 kinetics in visceral obesity: Associations with plasma apolipoprotein C-III concentration

Cited by 130 publications

References 26 publications

Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels

Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels

Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women

Stable isotopes in obesity research

Contact Info

Product

Resources

About