Apolipoprotein D

Rassart, Éric; Desmarais, Frédérik; Najyb, Ouafa; Bergeron, Karl-F.; Mounier, Cathérine

doi:10.1016/j.gene.2020.144874

Cited by 67 publications

(66 citation statements)

References 182 publications

(263 reference statements)

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“…The novel fusion gene includes the APOD promoter region in association with the 3′ portion of the GLI1 coding sequence, including the C‐terminal zinc finger domain. APOD is expressed in most tissues, including fibroblasts and adipose tissue, supporting the idea that this gene's promoter could drive expression of a truncated GLI1 protein 6 . This finding parallels other described GLI1 ‐rearranged neoplasms (i.e.…”

Section: Figuresupporting

confidence: 82%

“…APOD is expressed in most tissues, including fibroblasts and adipose tissue, supporting the idea that this gene's promoter could drive expression of a truncated GLI1 protein. 6 This finding parallels other described GLI1-rearranged neoplasms (i.e. those with ACTB-GLI1, MALAT1-GLI1, and PTCH1-GLI1), in which promoter swapping has been proposed as the mechanism of GLI1 oncogenic activation.…”

supporting

confidence: 85%

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Novel APOD–GLI1 rearrangement in a sarcoma of unknown lineage

et al. 2020

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Section: Figuresupporting

confidence: 82%

supporting

confidence: 85%

Novel APOD–GLI1 rearrangement in a sarcoma of unknown lineage

et al. 2020

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“…Apolipoprotein D (ApoD) is a 25-30 kDa glycosylated protein belonging to the lipocalin superfamily of hydrophobic molecule carriers [1][2][3][4]. ApoD is known for its ability to bind various ligands, including arachidonic acid (ARA) and progesterone [1,5,6]. ApoD can bind ARA and mediate its release from cell membranes.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, since ARA is the precursor of the eicosanoid class of lipid inflammation mediators, ApoD's capacity to bind ARA allows it to modulate the production of eicosanoids and attenuate inflammation [7,8]. ApoD can also limit inflammation and oxidative stress by reducing oxidized lipids [1,[9][10][11][12]. Because it is overexpressed during many neurodegenerative diseases and stresses, ApoD is considered an important factor in brain protection and repair [9,11,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues

Desmarais

Hervé

Bergeron

et al. 2021

IJMS

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Apolipoprotein D (ApoD) is a secreted lipocalin associated with neuroprotection and lipid metabolism. In rodent, the bulk of its expression occurs in the central nervous system. Despite this, ApoD has profound effects in peripheral tissues, indicating that neural ApoD may reach peripheral organs. We endeavor to determine if cerebral ApoD can reach the circulation and accumulate in peripheral tissues. Three hours was necessary for over 40% of all the radiolabeled human ApoD (hApoD), injected bilaterally, to exit the central nervous system (CNS). Once in circulation, hApoD accumulates mostly in the kidneys/urine, liver, and muscles. Accumulation specificity of hApoD in these tissues was strongly correlated with the expression of lowly glycosylated basigin (BSG, CD147). hApoD was observed to pass through bEnd.3 blood brain barrier endothelial cells monolayers. However, cyclophilin A did not impact hApoD internalization rates in bEnd.3, indicating that ApoD exit from the brain is either independent of BSG or relies on additional cell types. Overall, our data showed that ApoD can quickly and efficiently exit the CNS and reach the liver and kidneys/urine, organs linked to the recycling and excretion of lipids and toxins. This indicated that cerebral overexpression during neurodegenerative episodes may serve to evacuate neurotoxic ApoD ligands from the CNS.

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Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

Bhale,

Meilhac,

d'Hellencourt

et al. 2024

BioFactors

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High‐density lipoproteins (HDLs) play a vital role in lipid metabolism and cardiovascular health, as they are intricately involved in cholesterol transport and inflammation modulation. The proteome of HDL particles is indeed complex and distinct from other components in the bloodstream. Proteomics studies have identified nearly 285 different proteins associated with HDL; however, this review focuses more on the 15 or so traditionally named “apo” lipoproteins. Important lipid metabolizing enzymes closely working with the apolipoproteins are also discussed. Apolipoproteins stand out for their integral role in HDL stability, structure, function, and metabolism. The unique structure and functions of each apolipoprotein influence important processes such as inflammation regulation and lipid metabolism. These interactions also shape the stability and performance of HDL particles. HDLs apolipoproteins have multifaceted roles beyond cardiovascular diseases (CVDs) and are involved in various physiological processes and disease states. Therefore, a detailed exploration of these apolipoproteins can offer valuable insights into potential diagnostic markers and therapeutic targets. This comprehensive review article aims to provide an in‐depth understanding of HDL apolipoproteins, highlighting their distinct structures, functions, and contributions to various physiological processes. Exploiting this knowledge holds great potential for improving HDL function, enhancing cholesterol efflux, and modulating inflammatory processes, ultimately benefiting individuals by limiting the risks associated with CVDs and other inflammation‐based pathologies. Understanding the nature of all 15 apolipoproteins expands our knowledge of HDL metabolism, sheds light on their pathological implications, and paves the way for advancements in the diagnosis, prevention, and treatment of lipid and inflammatory‐related disorders.

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Apolipoprotein D

Cited by 67 publications

References 182 publications

Novel APOD–GLI1 rearrangement in a sarcoma of unknown lineage

Novel APOD–GLI1 rearrangement in a sarcoma of unknown lineage

Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues

Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

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