Apolipoprotein E gene polymorphism in renal transplant recipients: effects on lipid metabolism, atherosclerosis and allograft function

Kahraman, Serkan; Kıykım, Ahmet; Altun, Bülent; Gençtoy, Gültekin; Arıcı, Mustafa; Gülsün, Meltem; Erdem, Yunus; Yasavul, Ünal; Turgan, Çetin; Çağlar, Şali

doi:10.1111/j.1399-0012.2004.00162.x

Cited by 14 publications

(15 citation statements)

References 30 publications

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“…With the most recent updates, the forecast is less favorable, with only one positive study out of three [30,34,35]. The studies, however, were carried out in selected populations, namely CHD patients, renal transplant patients, and alcohol abusers; this could further complicate the ability to detect associations.…”

Section: Updates On Ace Apoe Mthfr Pon1 and Mmp3mentioning

confidence: 88%

Genetic determinants of carotid ultrasound traits

Pollex¹,

Hegele

2006

Curr Atheroscler Rep

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Atherosclerosis is a complex disease with various intermediate phenotypes that are themselves complex and influenced by many factors. Through the use of carotid ultrasound techniques, the intermediate stages of vascular disease can be imaged and studied for association with potential genetic determinants. In this article we review the most recent available data (reports published since 2004) on the genetic determinants of atherosclerosis, as measured by one-, two-, and three-dimensional ultrasonography of the carotid arteries. In general, associations are disparate and modest. For intima-media thickness, promising associations have been found for both TNFRSF1A R92Q and PPARG P12A, but associations also differed in the same individuals depending on the specific ultrasound trait studied (eg, linear intima-media thickness versus total plaque volume in carotid arteries). Some of the challenging issues for future studies include accounting for gene-environment interactions, sex-specific associations, and the distinctiveness of different carotid ultrasound measures.

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Section: Updates On Ace Apoe Mthfr Pon1 and Mmp3mentioning

confidence: 88%

Genetic determinants of carotid ultrasound traits

Pollex¹,

Hegele

2006

Curr Atheroscler Rep

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“…Four kinds of gene polymorphisms comparisons were contained, they were E2E3 vs. E3E3 (13 reports [19][20][21][22][23][24][25][26][27][28][29][30][31] ), E2E4 vs. E3E3(4 reports [19][20][21]23 ), E3E4 vs. E3E3 (13 reports [19][20][21][22][23][24][25][26][27][28][29][30][31] ) and E4E4 vs. E3E3 (4 reports 19-21, 23). Another five types of apoE gene polymorphisms were ε 2 vs. non-ε 2(1 report32), ε 4 with nonε 4(4 studies [33][34][35][36] ), ε 2 vs. ε 3(15 studies 20,22,[24][25][26][27][28][29][30][37][38][39][40][41][42]<...>…”

Section: Study Characteristics For the Association Between Gene Polymmentioning

confidence: 99%

“…One report 32 was included for the meta-analysis of ε 2 vs. non-ε 2 (including 2 comparisons), and 4 studies [33][34][35][36] were recruited into our meta-analysis for the comparison of ε 4 with non-ε 4 (including 6 comparisons). Fifteen studies 20,22,[24][25][26][27][28][29][30][37][38][39][40][41][42][43] were included into the study for ε 2 vs. ε 3 (including 21 comparisons), 16 studies ( 20, 22, 24-30, 37-39, 41-44 ) were included into the study for ε 4 vs. ε 3 (including 21 comparisons), and 15 studies 20, 22, 24-30, 37-39, 41-43 were included into the study of ε 2 VS ε 4 (including 20 comparisons).…”

Section: Study Characteristics Of the Association Between Gene Polymomentioning

confidence: 99%

“…Three studies 24,30,38 were included into the study of ε 2 vs. ε 3 (including 4 comparisons). Three studies (24,30,38) were included into the investigation of ε 4 vs. ε 3 (including 4 comparisons). Three studies 24,30,38 were included into the study of ε 2 vs. ε 4 (including 4 comparisons).…”

Section: Study Characteristics For the Association Between Gene Polymmentioning

confidence: 99%

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Association of apoE gene polymorphisms with lipid metabolism in renal diseases

Zhou

Zhong

et al. 2020

Afr H. Sci.

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Background and Objectives: Apolipoprotein E (apoE) plays a central role in the metabolism and homeostasis of lipids. ApoE gene encodes three major isoforms: ε2, ε3 and ε4 forming six phenotypes: Ε2Ε2, Ε2Ε3, Ε2Ε4, Ε3Ε3, Ε3Ε3 and Ε4Ε4 . Disorders of the lipid metabolism and the homeostasis are frequently coexist in renal diseases. The association be- tween gene polymorphisms of apoE and lipid metabolism were not consistent. This meta-analysis was performed to assess the association between gene polymorphisms of apoE and lipid metabolism in renal diseases. Methods: A pre-defined literatures search and selection of eligible relevant investigations were performed to extract and collect data from electronic databases. Results: Sixteen articles were enrolled for the analysis of association between apoE gene polymorphisms and lipid metab- olism. Subjects with E3E4 had a higher total cholesterol (TC) than those with E3E3, and subjects with E2E3 had a lower TC than those with E3E3. Subjects with ε2, ε3 had a lower TC than those with ε2, ε3 or ε4 , and subjects with ε4 had a higher TC than those with ε2, ε3 . Subjects with E2E2, E2E3 or E4E4 had a higher triglyceride (TG) than those with E3E3. Subjects with ε4 had a higher TG than those with ε2, ε3 . Subjects with ε2, ε3 had a higher level of TG than those with non-ε2, ε3 . Subjects with E3E4 had a slightly lower high-density lipoprotein (HDL) than those with E3E3. E3E4 appeared to be associated with lower levels of HDL. Subjects with E2E2, E2E3 had a notably lower low-density lipoprotein (LDL) than those with E3E3. Subjects with ε2, ε3 had a lower LDL than those with ε2, ε3 or ε4 ApoE gene polymorphisms were not associated with very low-density lipoprotein, and lipoprotein (a) [Lp(a)]. Subjects with E2E3 or E2E4 had higher apoE levels than those with E3E3, and subjects with E4E4 had lower apoE levels than those with E3E3. Conclusion: ApoE gene polymorphisms are associated with the expression of TC, TG HDL, LDL, Lp(a) or apoE. Keywords: Apolipoprotein E (ApoE) ; gene polymorphism; total cholesterol (TC) ;triglyceride (TG), high-density lipopro- tein (HDL); low-density lipoprotein (LDL); very low-density lipoprotein (VLDL); lipoprotein (a) [Lp(a)] • Meta-analysis

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“…Eighteen studies 12,13,[15][16][17][18][19][20][21][22][26][27][28][29][30][31][32]34 were included into the study of e4 versus e3 (including 29 comparisons). Seventeen studies 12,13,[15][16][17][18][19][20][21][22][26][27][28][29][30][31][32] were included into the study of e2 versus e4 (including 27 comparisons).…”

Section: Study Characteristics For the Relationship Between Apoe Genementioning

confidence: 99%

Relationship between apolipoprotein E gene polymorphism with triglyceride level in patients with renal diseases

et al. 2013

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Apolipoprotein E (apoE), one of the major plasma lipoproteins, plays a major role in the transport and metabolism of lipids by acting as a ligand. apoE gene contains three potential alleles: e2, e3 and e4, forming six genotypes: E2E2, E2E3, E2E4, E3E3, E3E3 and E4E4. Association between apoE gene polymorphism and triglyceride (TG) is still controversial. There was no any meta-analysis to explore the association of apoE gene polymorphism with triglyceride level, and this meta-analysis was performed to evaluate the association between apoE gene polymorphism and triglyceride in patients with renal diseases. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Twenty-four articles were identified for the analysis of association between apoE gene polymorphism and triglyceride level. Subjects with E2E3 or E3E4 had a higher TG than those with E3E3. Subjects with e4 had a higher TG than those with e3. Subjects with e2 had a slightly higher TG than those with e3, although there was no statistical difference. Interestingly, subjects with e4 had a much higher TG than those with e2. In conclusion, E2E3, E3E4 or e4 was associated with higher level of TG. However, more studies should be performed in the future.

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Apolipoprotein E gene polymorphism in renal transplant recipients: effects on lipid metabolism, atherosclerosis and allograft function

Cited by 14 publications

References 30 publications

Genetic determinants of carotid ultrasound traits

Genetic determinants of carotid ultrasound traits

Association of apoE gene polymorphisms with lipid metabolism in renal diseases

Relationship between apolipoprotein E gene polymorphism with triglyceride level in patients with renal diseases

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