Relationship between apolipoprotein E gene polymorphism with triglyceride level in patients with renal diseases

Abstract

Apolipoprotein E (apoE), one of the major plasma lipoproteins, plays a major role in the transport and metabolism of lipids by acting as a ligand. apoE gene contains three potential alleles: e2, e3 and e4, forming six genotypes: E2E2, E2E3, E2E4, E3E3, E3E3 and E4E4. Association between apoE gene polymorphism and triglyceride (TG) is still controversial. There was no any meta-analysis to explore the association of apoE gene polymorphism with triglyceride level, and this meta-analysis was performed to evaluate the association between apoE gene polymorphism and triglyceride in patients with renal diseases. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Twenty-four articles were identified for the analysis of association between apoE gene polymorphism and triglyceride level. Subjects with E2E3 or E3E4 had a higher TG than those with E3E3. Subjects with e4 had a higher TG than those with e3. Subjects with e2 had a slightly higher TG than those with e3, although there was no statistical difference. Interestingly, subjects with e4 had a much higher TG than those with e2. In conclusion, E2E3, E3E4 or e4 was associated with higher level of TG. However, more studies should be performed in the future.

Interactive effects of C-reactive protein levels on the association between APOE variants and triglyceride levels in a Taiwanese population

“…Nevertheless, some studies have reported positive findings, particularly for the ε4 variant. Dong et al (2013) showed that ε4 was associated with higher triglyceride levels in patients with renal disease [ 35 ]. Carvarlho-Wells et al (2010) reported that ε4 carriers have higher postprandial triglyceride levels only in adults aged >50 years [ 45 ].…”

Apolipoprotein E gene polymorphism and renal function are associated with apolipoprotein E concentration in patients with chronic kidney disease

“…Wang Y et al proved that hemodialysed ε4 allele carriers have higher total cholesterol (TC), TG, and LDL-C [27]. ε2 allele carriers develop accumulation of cholesterol-rich VLDL [28]. However, there is poor knowledge about the relationship between APOE gene polymorphism, APOE level, its distribution among lipoproteins and the degree of kidney dysfunction, especially at early stages of CKD.…”