Apolipoprotein E genotyping in the Malay, Chinese and Indian ethnic groups in Malaysia—a study on the distribution of the different apoE alleles and genotypes

Seet, Wan Tai; Anne, Tan Jin Ai Mary; Yen, Tan Si

doi:10.1016/j.cccn.2003.11.001

Cited by 32 publications

(22 citation statements)

References 14 publications

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“…The gene frequency of ε 4 allele was from 12.4% to 19.8% in Caucasians, while the Chinese Han ethnic population has been found to have a lower frequency of the ε 4 allele, ranging from 7.5% to 8.7% [8, 13, 26]. Regarding other Chinese minorities, the frequency of ε 4 allele ranged from 4.9% in the Zhuang ethnic group [29] to 15.4% in the Mongolian ethnic group [30].…”

Section: Discussionmentioning

confidence: 99%

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The Association between Apolipoprotein E Gene Polymorphism and Mild Cognitive Impairment among Different Ethnic Minority Groups in China

Wang

Ma²,

Yao

et al. 2014

International Journal of Alzheimer's Disease

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The association, in different ethnic groups, of apolipoprotein E (apoE) gene polymorphism with mild cognitive impairment (MCI) has been unclear. Few studies have examined the association in Chinese minorities. The current study explores the association between apoE gene polymorphism and MCI in one of the biggest ethnic groups—the Hui—and compares it with the Han. The Minimental State Exam, Activities of Daily Living Scale, and Geriatric Depression Scale were administered to 306 ethnic Hui and 618 ethnic Han people aged ≥55 years. ApoE genotypes were determined using the high resolution melting curve method. The distribution of the apoE genotype and the frequency of alleles ε2, ε3, and ε4 were similar in the Hui and Han groups. In analyses adjusted for age, gender, and education level, the ε4 allele was a risk factor for MCI in both the Hui group (OR = 2.61, 95% CI: 1.02–6.66) and the Han group (OR = 2.36, 95% CI: 1.19–4.67), but the apoE ε2 allele was protective for MCI only in the Han group (OR = 0.48, 95% CI: 0.38–0.88). The association of some apoE genotypes with MCI may differ in different ethnic groups in China. Further studies are needed to explore this effect among different populations.

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Section: Discussionmentioning

confidence: 99%

“…Seet et al reviewing the frequency of the apoE alleles in different ethnic groups found that the relative frequency of ε 4 was the lowest in the Chinese sample [8]. This raised a question as to whether the Chinese people did in fact benefit from the reduced frequency of the apoE ε 4 allele.…”

Section: Introductionmentioning

confidence: 99%

The Association between Apolipoprotein E Gene Polymorphism and Mild Cognitive Impairment among Different Ethnic Minority Groups in China

Wang

Ma²,

Yao

et al. 2014

International Journal of Alzheimer's Disease

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“…Another study compared APOE genotypes in different ethnic groups in Malaysia and reported an 4 frequency in ethnic Malays of 13.5%. 56 The Chamorros therefore have an exceptionally low 4 frequency, even among Pacific islanders. The APOE findings in Chamorros are comparable to those in an Arab population studied in Israel, 57 where the 4 frequency was 3.5% in controls and 4.5% in patients with AD.…”

Section: Figurementioning

confidence: 98%

Prevalence of dementia in Chamorros on Guam

et al. 2007

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“…Three common alleles (e2, e3, e4) constitute six genotypes, such that there are three homozygous (E2/E2, E3/E3, E4/E4) and three heterozygous (E3/E2, E4/E2, E4/E3). Among these genotypes, E3/E3 is the wild type and overwhelming in different populations with evident ethnic heterogeneity [21,22]. In general, individuals with the e2 allele tend to have lower levels, whereas individuals with e4 allele have higher levels of serum cholesterol in comparison to individuals who are homozygous for the e3 allele [23,24].…”

Section: Discussionmentioning

confidence: 97%

Genetic variation of apolipoprotein E does not contribute to the lipid abnormalities secondary to childhood minimal change nephrotic syndrome

Qin

Lü

et al. 2009

Int Urol Nephrol

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Minimal change nephrotic syndrome (MCNS) is a common progressive renal disorder occurring in childhood that is characterized by alterations of permselectivity at the glomerular capillary wall, resulting in its inability to restrict the urinary loss of protein. Hyperlipidemia (HLP) is not only an important clinical manifestation of MCNS but is also involved in cardiovascular disease and in progressive renal damage. ApoE is a polymorphic protein. Besides modulation of lipid metabolism, apoE can also elevate the sulfate-proteoglycan in glomerular filtration membrane and inhibit the proliferation of mesengial cells. The present study aimed mainly to determine whether genetic polymorphism of apoE is involved in the HLP secondary to childhood MCNS. Genomic DNA was extracted from 250 children diagnosed with MCNS and 200 healthy controls. ApoE genotype was determined by PCR-restriction fragment length polymorphism (RFLP) analysis. The fasting serum lipoprotein (a) [Lp(a)], total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (apoA1), and apoB were measured. Serum concentrations of Lp(a), TC, TG, HDL-C, nonHDL-C, LDL-C, and apoB were higher in the MCNS than in the control group (P < 0.05). No significant differences in genotypes and alleles frequencies were observed for the apoE Hha I restriction sites in MCNS patients as compared to controls (P > 0.05). No significant differences in serum lipid levels were observed for variant genotypes and alleles of apoE Hha I restriction site in both MCNS and healthy children (P > 0.05). Genetic variation of apoE does not contribute to the lipid abnormalities secondary to childhood MCNS.

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Apolipoprotein E genotyping in the Malay, Chinese and Indian ethnic groups in Malaysia—a study on the distribution of the different apoE alleles and genotypes

Cited by 32 publications

References 14 publications

The Association between Apolipoprotein E Gene Polymorphism and Mild Cognitive Impairment among Different Ethnic Minority Groups in China

The Association between Apolipoprotein E Gene Polymorphism and Mild Cognitive Impairment among Different Ethnic Minority Groups in China

Prevalence of dementia in Chamorros on Guam

Genetic variation of apolipoprotein E does not contribute to the lipid abnormalities secondary to childhood minimal change nephrotic syndrome

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