Apolipoprotein E Polymorphism and Its Association with Serum Lipid Levels in Brazilian Children

França, Everaldo de; Alves, João Guilherme Bezerra; Hutz, Mara Helena

doi:10.1353/hub.2004.0030

Cited by 30 publications

(20 citation statements)

References 28 publications

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“…Similar concentrations have been detected 11.0%) (Bernstein et al, 2002) and French (8.0%, 80.0%, and 12.0%) (Marques-Vidal et al,2003) population. Furthermore, no difference in allele or genotype frequency was observed between genders, in agreement with other studies (Correla et al, 2001;França et al, 2004;Nascimento et al, 2009).…”

Section: Discussionsupporting

confidence: 92%

“…The same has been reported for children (Nghiem et al, 2004) and other adolescents (França et al, 2004). In addition, the probability of elevated TC was 27% and 32% higher among ε3 and ε4 carriers than ε2 carriers ( Table 2).…”

Section: Discussionsupporting

confidence: 84%

“…In agreement with this finding, lower concentrations of this lipoprotein have been demonstrated in children (Nghiem et al, 2004) and other adolescents (França, Alves & Hutz, 2004) with ε2 allele. The probability of elevated LDL cholesterol ranged from 10% to 44% among adolescents carrying ε4 allele compared to the other alleles and was 30% higher in ε3 than ε2 carriers (Table 2).…”

Section: Discussionsupporting

confidence: 79%

“…This finding agrees with other studies involving adolescents (França, Alves & Hutz, 2004;Nascimento et al, 2009), but disagrees with the studies of Medina-Urrutia et al (2004) and Nghiem et al (2004). In addition, the APOE alleles were not associated with low HDL cholesterol (Table 2), as also observed in adults (Alvim et al, 2010).…”

Section: Discussionsupporting

confidence: 77%

“…The major alleles are called epsilon two (ε2), three (ε3) and four (ε4) and are important modulators of serum lipemia. In general, individuals carrying the ε2 allele present lower serum concentrations of TC and LDL (Alvim et al, 2010;Bernstein et al, 2002;Corella et al, 2001;França, Alves, & Hutz, 2004;Nghiem et al, 2004) whereas the opposite is observed for those carrying ε4 allele (Bernstein et al, 2002;Corella et al, 2001; Medina-Urrutia, Cardoso-Saldaña, ZamoraGonzález, Liria, & Posadas-Romero, 2004;Nascimento et al, 2009). The association between APOE alleles and lipemia seems to be influenced by physical activity levels.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

Glaner¹,

Nascimento²,

Nóbrega³

2014

Motriz: rev. educ. fis.

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Abstract-The purpose of this study was to analyze the association between APOE alleles and serum lipemia in adolescents with low and adequate aerobic fitness. The sample was comprised of 105 boys and 151 girls (49% and 46% from rural area) of European ancestry, aged 11 to 17 years, and classified according to: 1) APOE genotype: group ε2 (ε2/3+ε2/2), ε3 (ε3/3), and ε4 (ε3/4+ε4/4); 2) aerobic fitness: adequate or low; 3) serum lipemia: elevated total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides, and low high-density lipoprotein (HDL). The results showed that aerobic fitness modulates the association between APOE alleles and serum lipemia in adolescents, suggesting that adequate aerobic fitness levels exert a greater effect of reducing TC and LDL in ε2 carriers, as well as of increasing HDL and reducing triglycerides in ε3 and ε4 carriers. Keywords: apolipoproteins E, physical endurance, adolescent health, lipoproteinsResumo-"Aptidão física aeróbica modula a associação entre genótipos da APOE e lipemia sérica em adolescentes." O objetivo deste estudo foi analisar a associação entre os alelos da APOE e a lipemia sérica em adolescentes com baixa e adequada aptidão aeróbia. Amostra: 105 rapazes(49% da área rural) e 151 moças (46% da área rural) descendentes de europeus, com idade de 11 a 17 anos, classificados de acordo com 1) genótipo da APOE: grupo ε2 (ε2/3+ε2/2), ε3 (ε3/3), e ε4 (ε3/4+ε4/4); 2) aptidão aeróbia: adequada ou baixa; 3) lipemia sérica: elevados colesterol total (CT), lipoproteína de baixa densidade (LDL) e triglicérides, e baixa lipoproteína de alta densidade (HDL). Os resultados demonstram que a aptidão aeróbia modula a associação dos alelos da APOE com a lipemia sérica de adolescentes, sugerindo que níveis adequados de aptidão aeróbia têm efeito maior em reduzir CT e LDL elevados nos portadores do alelo ε2, bem como o efeito maior em aumentar HDL e reduzir triglicerídeos naqueles com ε3 e ε4. Palavras-chave: apolipoproteína E, resistência física, saúde do adolescente, lipoproteínasResumen-"La condición física aeróbica modula la asociación entre los genotipos APOE y lipemia sérico en adolescentes." El objetivo fue analizar la asociación entre los alelos APOE y la lipemia sérica en adolescentes con baja y adecuada condición aeróbica. La muestra fue composta de 105 niños (49% de las zonas rurales) y 151 niñas (46% de las zonas rurales) de origen europeo, con edades entre 11-17 años, clasificados de acuerdo con 1) el genotipo APOE: grupo ε2 (ε2 / 3 + ε2 / 2), ε3 (ε3 / 3), y ε4 (ε3 / ε4 + 4/4); 2) la condición aeróbica: adecuada o baja; 3) suero lipémico: colesterol (CT), lipoproteínas de baja densidad (LDL) y los triglicéridos elevados y lipoproteínas de alta densidad (HDL) bajo. Los resultados muestran que la capacidad aeróbica modula la asociación de los alelos APOE con la lipemia de los adolescentes, lo que sugiere que niveles adecuados de capacidad aeróbica tienen mayor efecto en la reducción de CT y LDL elevados en el alelo ε2, y el mayor efecto para aumentar el HDL y la reducci...

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

Glaner¹,

Nascimento²,

Nóbrega³

2014

Motriz: rev. educ. fis.

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Relative variations of gut microbiota in disordered cholesterol metabolism caused by high‐cholesterol diet and host genetics

Tao

Shao

et al. 2017

MicrobiologyOpen

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Recent studies performed provide mechanistic insight into effects of the microbiota on cholesterol metabolism, but less focus was given to how cholesterol impacts the gut microbiota. In this study, ApoE−/− Sprague Dawley (SD) rats and their wild‐type counterparts (n = 12) were, respectively, allocated for two dietary condition groups (normal chow and high‐cholesterol diet). Total 16S rDNA of fecal samples were extracted and sequenced by high‐throughput sequencing to determine differences in microbiome composition. Data were collected and performed diversity analysis and phylogenetic analysis. The influence of cholesterol on gut microbiota was discussed by using cholesterol dietary treatment as exogenous cholesterol disorder factor and genetic modification as endogenous metabolic disorder factor. Relative microbial variations were compared to illustrate the causality and correlation of cholesterol and gut microbiota. It turned out comparing to genetically modified rats, exogenous cholesterol intake may play more effective role in changing gut microbiota profile, although the serum cholesterol level of genetically modified rats was even higher. Relative abundance of some representative species showed that the discrepancies due to dietary variation were more obvious, whereas some low abundance species changed because of genetic disorders. Our results partially demonstrated that gut microbiota are relatively more sensitive to dietary variation. Nevertheless, considering the important effect of bacteria in cholesterol metabolism, the influence to gut flora by “genetically caused cholesterol disorder” cannot be overlooked. Manipulation of gut microbiota might be an effective target for preventing cholesterol‐related metabolic disorders.

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Apolipoprotein A5-1131T>C polymorphism, but not APOE genotypes, increases susceptibility for dyslipidemia in children and adolescents

et al. 2010

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Apolipoprotein A5 (APOA5) and apolipoprotein E (APOE) play important roles in the metabolism of cholesterol and triglycerides. The aim of this study was to determine the allelic and genotypic distributions of the APOA5-1131T>C (rs 662799) and the APOE HhaI polymorphisms and to identify the association of both individual and combined APOA5-APOE genetic variants and the risk for dyslipidemia in children and adolescents. We genotyped 53 dyslipidemic and 77 normolipidemic individuals. The total cholesterol, triglycerides and HDL cholesterol were determined enzymatically. For APOA5 polymorphism, the presence of the allele C confers an individual risk for dyslipidemia (OR = 2.38, 95% CI = 1.15-4.89; P = 0.018). No significant differences were observed for lipid parameters among the APOA5 groups, except for a higher value of HDLc (P = 0.024) in C-carriers. The allelic and genotypic frequencies of APOE polymorphism were similar between groups and did not increase the susceptibility for dyslipidemia. None of the combined APOA5-APOE polymorphisms increased risk for dyslipidemia. We demonstrated an association between APOA5-1131T>C polymorphism and dyslipidemia in children and adolescents. This finding may be useful to guide new studies with genetic markers down a path toward a better characterization of the genetic risk factors for dyslipidemia and atherosclerotic diseases.

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Apolipoprotein E Polymorphism and Its Association with Serum Lipid Levels in Brazilian Children

Cited by 30 publications

References 28 publications

Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

Relative variations of gut microbiota in disordered cholesterol metabolism caused by high‐cholesterol diet and host genetics

Apolipoprotein A5-1131T>C polymorphism, but not APOE genotypes, increases susceptibility for dyslipidemia in children and adolescents

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