Apolipoproteins C-II and C-III metabolism in hypertriglyceridemic patients Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration

Malmendier, Claude; Lontie, Jean-Francois; Delcroix, Claude; Dubois, D.Y.; Magot, T.; Roy, L. De

doi:10.1016/0021-9150(89)90075-0

Cited by 92 publications

(57 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies have demonstrated that the hypotriglyceridemic effect of fibrates was mediated in part via the peroxisome proliferator-activated receptors (PPAR)-a through the inhibition of apoC-III gene transcription and the upregulation of the LPL gene (Schoonjans et al, 1996). This may explain part of the results obtained by Malmendier et al (1989). Although data concerning the modulating impact of dietary factors on gene expression are still scarce, they are the focus of increasing interest.…”

Section: Discussionmentioning

confidence: 92%

“…Our results concur with these data in that the lack of change in plasma TG and apoC-III concentrations with the ad libitum consumption of the low-fat control diet mirrored the absence of change in apoCIII metabolism. Malmendier et al (1989) investigated the effect of a combined treatment comprising a restricted hypocaloric diet limited in fat and 300 mg fenofibrate daily on the kinetics of 131 I-apoC-III in four hypertriglyceridemic men. After 1 month of treatment, reductions in plasma TG and apoC-III levels (À56 and À48%, respectively) were observed, which were associated with an increase in apoC-III catabolism and a decrease in apoC-III production.…”

Section: Discussionmentioning

confidence: 99%

“…After 1 month of treatment, reductions in plasma TG and apoC-III levels (À56 and À48%, respectively) were observed, which were associated with an increase in apoC-III catabolism and a decrease in apoC-III production. Because a combined treatment was used, the authors were not able to differentiate which of the diet and the fenofibrate treatment was responsible for the observed effects (Malmendier et al, 1989). Studies have demonstrated that the hypotriglyceridemic effect of fibrates was mediated in part via the peroxisome proliferator-activated receptors (PPAR)-a through the inhibition of apoC-III gene transcription and the upregulation of the LPL gene (Schoonjans et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Only a limited number of studies have investigated the impact of nonpharmacological treatments such as diet on plasma apoC-III metabolism and concentration (Huff and Nestel, 1982;Malmendier et al, 1989). We have recently shown that when consumed under ad libitum conditions, a high-fat diet rich in monounsaturated fatty acid (MUFA) significantly reduced plasma TG and apoC-III levels, whereas a low-fat control diet had no significant impact on these variables (Archer et al, 2003a(Archer et al, , 2005.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels

Desroches

Deshaies

et al. 2007

Eur J Clin Nutr

View full text Add to dashboard Cite

Objective: To compare the effect of a high monounsaturated fatty acid (MUFA) diet and of a control low-fat diet consumed under ad libitum conditions on plasma apolipoprotein (apo) C-III metabolism. Design: Randomized, two-arm parallel dietary trial. Setting: Diets were prepared and consumed at the metabolic kitchen of the Department of Food Sciences and Nutrition, and laboratory analyses were performed at the Institute of Nutraceuticals and Functional Foods at Laval University. Subjects and interventions: Eighteen men were randomly assigned to either the high MUFA diet or the low-fat control diet, which they consumed for 6-7 weeks. Before and after the dietary intervention, subjects received a primed-constant infusion of [5,5,5-D 3 ]-L-leucine for 12 h under constant feeding conditions for the determination of plasma apoC-III kinetics. Results: The high-MUFA diet and the low-fat control diet had no significant impact on plasma apoC-III production rate (PR) or fractional catabolic rate. However, diet-induced variations in plasma apoCIII PR predicted the reduction in plasma triglycerides and apoC-III levels (r ¼ 0.85, Po0.01 and r ¼ 0.73, Po0.05, respectively) in the high MUFA group only. Conclusions: These results suggest that the hypotriglyceridemic effect of a high-MUFA diet may be attributable in part to a reduced hepatic production of apoC-III.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels

Desroches

Deshaies

et al. 2007

Eur J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…Both fibratesFagonists of peroxisome proliferator-activated receptor alpha (PPARa)Fand retinoidsFpanagonists of the retinoic acid receptors RAR and RXRFwere commonly shown to influence triglyceridemia through changing the expression of apolipoprotein C-III (ApoC-III) gene. 6,7 This gene alone as well as the whole ApoA-I/C-III/A-IV cluster (and most recently its new member, ApoA-V) were associated with dyslipidemia in human populations and animal models 3,8 and were also suggested as putative candidates for hypertriglyceridemia in a genetic model of insulin resistance syndrome, polydactylous (PD/Cub) rat strain [9][10][11][12][13][14] (http:// www.img.cas.cz/fb/, Table 1). Therefore, we examined the effect of fenofibrate and isotretinoin administration on metabolic profile, insulin sensitivity and lipolysis in tissues and the expression of ApoC-III and one of its proposed upstream regulatory genes, hepatocyte nuclear factor-4 (Hnf-4), in the PD/Cub rat strain.…”

Section: Introductionmentioning

confidence: 99%

Isotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome

et al. 2004

View full text Add to dashboard Cite

OBJECTIVE:To investigate the effect of transcription-modulating drugs, fenofibrate and isotretinoin, on metabolic profile, insulin sensitivity of adipose and muscle tissues and gene expression in a genetic model of insulin resistance syndrome, polydactylous rat strain (PD/Cub). DESIGN: Administration of fenofibrate (100 mg/kg/day), isotretinoin (30 mg/kg/day) or vehicle to adult male PD/Cub rats fed standard laboratory chow for 15 days. MEASUREMENTS: Parameters of lipid and carbohydrate metabolismForal glucose tolerance test, serum concentrations of insulin, triglycerides (TG), free fatty acids (FFA), glycerol, total cholesterol (CH); morphometric variables, in vitro insulin sensitivity of adipose and muscle tissues, catecholamine-stimulated lipolysis and the expression of ApoC-III and Hnf-4 genes in liver. RESULTS: Both experimental groups displayed an increase in adiposity with contrasting effects on TG (lowered by fenofibrate and increased by isotretinoin) and gene expression (no change in fibrate-treated rats and increased expression of ApoC-III and Hnf-4 in isotretinoin-treated group). Fenofibrate-treated rats also showed decreased concentrations of FFA and CH with concomitant decrease of catecholamine-induced lipolysis in adipocytes, but also hyperinsulinemia and the highest insulin/ glucose ratio. Isotretinoin increased glycerol concentrations and decreased the insulin sensitivity of peripheral tissues. CONCLUSION: The PD/Cub rat showed a distinct pharmacogenetic reaction to fenofibrate and isotretinoin administration. Several lines of evidence now implicate specific variant(s) of ApoC-III and/or ApoA-V alleles as responsible for the dyslipidemia observed in this genetic model. The PD/Cub strain may also serve as a pharmacogenetic model for dissection of the retinoidinduced hypertriglyceridemia.

show abstract

Kinetics of Heterogeneous Populations of Particles

Malmendier

Lontie

Delcroix

et al. 1990

Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics

View full text Add to dashboard Cite

Apolipoproteins C-II and C-III metabolism in hypertriglyceridemic patients Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration

Cited by 92 publications

References 22 publications

Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels

Kinetics of plasma apolipoprotein C-III as a determinant of diet-induced changes in plasma triglyceride levels

Isotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome

Kinetics of Heterogeneous Populations of Particles

Contact Info

Product

Resources

About