Apophysomyces elegans infection in a renal transplant recipient

Naguib, M. Tarek; Huycke, Mark M.; Pederson, James A.; Pennington, Larry R.; Burton, Michael D.; Greenfield, Ronald A.

doi:10.1016/0272-6386(95)90662-2

Cited by 36 publications

(39 citation statements)

References 17 publications

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“…A. elegans could not be isolated from the hospital premises (4). Nevertheless, a thorough environmental sampling of the community and the hospital en- A. elegans is known to cause cutaneous, subcutaneous, and soft tissue infections following trauma, burns, or invasive procedures in apparently healthy hosts (1,8,9,21,24,25,29,34). However, in the present series, besides four (50%) cases of cutaneous or subcutaneous tissue involvement, three (32%) patients had definite renal involvement due to A. elegans.…”

Section: Discussionmentioning

confidence: 99%

Apophysomyces elegans : an Emerging Zygomycete in India

Chakrabarti¹,

Ghosh²,

et al. 2003

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Apophysomyces elegans was considered a rare but medically important zygomycete. We analyzed the clinical records of eight patients from a single center in whom zygomycosis due to A. elegans was diagnosed over a span of 25 months. We also attempted a DNA-based method for rapid identification of the fungi and looked for interstrain polymorphism using microsattelite primers. Three patients had cutaneous and subcutaneous infections, three had isolated renal involvement, one had rhino-orbital tissue infection, and the final patient had a disseminated infection involving the spleen and kidney. Underlying illnesses were found in two patients, one with diabetes mellitus and the other with chronic alcoholism. A history of traumatic implantation was available for three patients. All except two of the patients responded to surgical and/or medical therapy; the diagnosis for the two exceptions was made at the terminal stage of infection. Restriction enzyme (MboI, MspI, HinfI) digestion of the PCR-amplified internal transcribed spacer region helped with the rapid and specific identification of A. elegans. The strains could be divided into two groups according to their patterns, with clustering into one pattern obtained by using microsatellite [(GTG) 5 and (GAC) 5 ] PCR fingerprinting. The study highlights the epidemiology, clinical spectrum, and diagnosis of emerging A. elegans infections.Zygomycosis is a serious and often rapidly fatal infection especially in immunocompromised patients. It is caused by sparsely septate filamentous, saprophytic fungi belonging to the class Zygomycetes and the order Mucorales.

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Section: Discussionmentioning

confidence: 99%

Apophysomyces elegans : an Emerging Zygomycete in India

Chakrabarti¹,

Ghosh²,

et al. 2003

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“…Infection with A. elegans is predominantly the result of the introduction of spore-containing soil or vegetation into traumatic wounds (6,66,134,207,288,316,322,342,376,493) or burns (93). In the two cases from Australia, the origin of infection was confirmed by culturing A. elegans from soil or dust samples at the site of exposure (93,415).…”

Section: Apophysomyces Elegansmentioning

confidence: 99%

“…Most patients, by far, demonstrate no underlying immune system dysfunction. In the patients having risk factors for developing a zygomycosis, three had diabetes (295,316,342). Several patients were immunocompromised: one with severe burns (93), one following renal transplantation (316), one with myelofibrosis (76), and three receiving steroids (295,316,342).…”

Section: Apophysomyces Elegansmentioning

confidence: 99%

Zygomycetes in Human Disease

Ribes¹,

Vanover-Sams²,

Baker³

2000

Clinical Microbiology Reviews

1,093

1,053

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“…Disseminated infection with A. elegans has also been reported after kidney transplantation from a donor who died by drowning (15). Recently, a cluster of cutaneous mucormycosis cases has been reported in the aftermath of the Joplin, MO, tornado, in which 13 of the confirmed cases yielded A. trapeziformis (8).…”

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confidence: 99%