Apoprotein C-III: A review of its clinical implications

Jin, Jing‐Lu; Guo, Yuan‐Lin; Li, Jianjun

doi:10.1016/j.cca.2016.06.016

Cited by 21 publications

(19 citation statements)

References 68 publications

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“…Although these authors used an approach slightly different from ours, they also separated patients by TG concentration. The larger size of VLDL in HTG may be related to our observation of high apoC-III content in these patients, because this apolipoprotein is a central regulator of VLDL catabolism acting as a specific inhibitor of lipoprotein lipase, that is, retarding the catabolism of VLDL particles [43]. On the other hand, apoE content was low in both FCH groups.…”

Section: Discussionmentioning

confidence: 74%

Familial Combined Hyperlipidemia (FCH) Patients with High Triglyceride Levels Present with Worse Lipoprotein Function Than FCH Patients with Isolated Hypercholesterolemia

et al. 2020

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Lipoprotein characteristics were analyzed in familial combined hyperlipidemia (FCH) patients before and after statin treatment. Twenty-six FCH patients were classified according to the presence (HTG group, n = 13) or absence (normotriglyceridemic (NTG) group, n = 13) of hypertriglyceridemia. Fifteen healthy subjects comprised the control group. Lipid profile, inflammation markers, and qualitative characteristics of lipoproteins were assessed. Both groups of FCH subjects showed high levels of plasma C-reactive protein (CRP), lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and apolipoprotein J. Statins reverted the increased levels of Lp-PLA2 and CRP. Lipoprotein composition alterations detected in FCH subjects were much more frequent in the HTG group, leading to dysfunctional low-density lipoproteins (LDL) and high-density lipoproteins (HDL). In the HTG group, LDL was smaller, more susceptible to oxidation, and contained more electronegative LDL (LDL(-)) compared to the NTG and control groups. Regarding HDL, the HTG group had less Lp-PLA2 activity than the NTG and control groups. HDL from both FCH groups was less anti-inflammatory than HDL from the control group. Statins increased LDL size, decreased LDL(-), and lowered Lp-PLA2 in HDL from HTG. In summary, pro-atherogenic alterations were more frequent and severe in the HTG group. Statins improved some alterations, but many remained unchanged in HTG.

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Section: Discussionmentioning

confidence: 74%

Familial Combined Hyperlipidemia (FCH) Patients with High Triglyceride Levels Present with Worse Lipoprotein Function Than FCH Patients with Isolated Hypercholesterolemia

et al. 2020

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“…Dyslipidemias in humans are common components of metabolic syndromes and are associated with other systemic changes [27], so that the study of their direct effect on carbohydrate metabolism becomes hampered. Based on this, the study of the effect of the altered lipid profile on the liver glucose metabolism in mice overexpressing apoCIII may determine whether there is a direct relationship between them.…”

Section: Discussionmentioning

confidence: 99%

Changes of Liver Glucose Metabolism in C57BL/6 Mice Transgenic for Human Apolipoprotein ApoCIII

Godoi¹,

Mamus²,

Rezende³

et al. 2018

JPP

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Mice overexpressing the human apolipoprotein apo CIII are a model of dyslipidemia. They become hypertriglyceridemic, hypercholesterolemic and have high blood levels of free fatty acids. Blood glucose is normal, but as the liver integrates lipid and carbohydrate metabolism, conditions of high inter-tissue circulation of energy substrates, such as fasting, may reveal hepatic alterations of glucose metabolism in these (CIII) mice. This hypothesis was explored by in situ liver perfusion in this investigation. The NTG (non-transgenic) animals showed liver and muscle glycogen content changes compatible with the fed or fasted state. In contrast, glycogen in group CIII was much lower in the fed state. The liver glucose release in group CIII after overnight fasting and adrenaline-stimulated was lower than in group NTG. Total glucose production under gluconeogenic conditions was not different between groups NTG and CIII, but glucose production from alanine was decreased in group CIII. Therefore, dyslipidemia caused by overexpression of apoCIII in mice alters the liver glucose metabolism, particularly compromising glycogen synthesis and degradation. This profile might have adverse outcomes during metabolic challenges that are more severe than fasting.

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“…ABCB4 (in BMSC and SCAP secretome) and hepatocyte nuclear factor 4 (in SCAP secretome only) have been reported to control the transport of organic anions and drugs and hence aiding in liver regeneration 38 . Apolipoprotein C-III (APOC3) is a VLDL protein and abrogate the hepatic and lipoprotein lipase 39 . Presence of this protein only in SCAP secretome might be a suggestive of limited hepatic potential of SCAP in comparison to DPSCs.…”

Section: Discussionmentioning

confidence: 99%

Molecular spectrum of secretome regulates the relative hepatogenic potential of mesenchymal stem cells from bone marrow and dental tissue

Kumar

Rattan

et al. 2017

Sci Rep

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Liver regeneration is a spontaneous process that occurs after liver injury, but acute liver failure is a complex and fatal disease which is difficult to treat. Cell-based therapies are promising alternative therapeutic approach for liver failure and different cell sources have been tested in this regard. We investigated the comparative hepatogenic potential of human bone marrow stem cells (BMSC) with stem cells derived from human dental pulp (DPSC), apical papilla (SCAP) and follicle (DFSC) during this study. Hepatogenic potential of stem cells was assessed by functional assays at both genetic and protein level. We observed higher expression of most of the hepatic markers post differentiation in DPSCs compared to other cell types. LC-MS/MS analysis of stem cell secretome revealed the presence of different proteins related to hepatogenic lineage like growth arrest specific protein 6, oncostatin M, hepatocyte growth factor receptor etc. Interactome and Reactome pathway analysis revealed the interaction of DPSC/SCAP secretome proteins and these proteins were found to be associated with various pathways involved in lipid transport and metabolism. To the best of our knowledge, this is the first study regarding detailed investigation of hepatogenic potential of BMSCs v/s DMSCs (DPSC, SCAP & DFSC) along-with secretome characterization.

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Apoprotein C-III: A review of its clinical implications

Cited by 21 publications

References 68 publications

Familial Combined Hyperlipidemia (FCH) Patients with High Triglyceride Levels Present with Worse Lipoprotein Function Than FCH Patients with Isolated Hypercholesterolemia

Familial Combined Hyperlipidemia (FCH) Patients with High Triglyceride Levels Present with Worse Lipoprotein Function Than FCH Patients with Isolated Hypercholesterolemia

Changes of Liver Glucose Metabolism in C57BL/6 Mice Transgenic for Human Apolipoprotein ApoCIII

Molecular spectrum of secretome regulates the relative hepatogenic potential of mesenchymal stem cells from bone marrow and dental tissue

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