Apoptosis and Programmed Cell Death in Health and Disease

Vermes, I.; Haanen, C.

doi:10.1016/s0065-2423(08)60336-4

Cited by 123 publications

(87 citation statements)

References 265 publications

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“…The amyloid ␤-peptide is derived from proteolysis of the amyloid precursor protein, a reaction catalyzed by ␤-and ␥-secretases (3,4). The enzyme ␤-secretase (BSEC) is essential for nerve cells to form the senile plaques (5)(6)(7)(8)(9). Most current therapeutic approaches to Alzheimer's disease involve finding drugs that block the BSEC catalytic site and disrupt its function.…”

mentioning

confidence: 99%

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Fluorescent-conjugated polymer superquenching facilitates highly sensitive detection of proteases

Kumaraswamy¹,

Bergstedt²,

Shi³

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

208

158

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mentioning

confidence: 99%

“…Apoptosis (programmed cell death) plays a significant role in several disease states (6,7). Because of a central role in inflammation and apoptosis, caspases (CASPs) have received enormous research attention (8).…”

mentioning

confidence: 99%

Fluorescent-conjugated polymer superquenching facilitates highly sensitive detection of proteases

Kumaraswamy¹,

Bergstedt²,

Shi³

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

208

158

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“…This indicated that kalopanaxsaponins A and I were effective against the drug resistant HepG2 cell line, but had no selective cytotoxicity towards cancer cells. Cell death can occur by either of two distinct mechanisms: necrosis ("accidental" cell death) and apoptosis ("programmed" cell death) [15,16]. Necrosis causes severe inflammation, while apoptosis does not.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxicity of Two Triterpenoids from Nigella glandulifera

et al. 2006

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During an investigation of antitumor substances from Nigella glandulifera Freyn et Sint. (Ranunculaceae) the cytotoxicity of two oleanane triterpene saponins isolated from the seeds of this species, kalopanaxsaponins A and I, was evaluated against HepG2, drug resistant HepG2 (R-HepG2) (two hepatocyte cell lines) and primary cultured normal mouse hepatocytes. Evident cytotoxic activities were observed. Morphological observations and cell cycle analysis suggest that these compounds inhibit the proliferation of hepatoma by inducing apoptosis and consequently kalopanaxsaponins A and I may be potential therapeutic agents for the treatment of parental and drug resistant hepatoma.

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“…in AIDS. A variety of extrinsic signals have been described to induce apoptosis (reviewed in: Vermes and Haanen, 1994); in our group we identified (i) physiological activators, neurotransmitters (Mu È ller et al, 1992), (ii) damage-related inducers, heat shock (Batel et al, 1993) and (iii) toxins, lead and prion protein as inducers of apoptosis. In AIDS patients excessive cell death has been described both for neurons and lymphocytes, a process which is assumed to be the major cause of this disease (Ameisen, 1992).…”

Section: Discussionmentioning

confidence: 95%

“…The induction of apoptotic cell death can emanate from endogenous signals, or can be induced by extracellular signals (reviewed in: Vermes and Haanen, 1994;Thompson, 1995). Both (i) failure of cells to undergo apoptosis, e.g.…”

Section: Discussionmentioning

confidence: 99%

Flupirtine protects both neuronal cells and lymphocytes against induced apoptosis in vitro: Implications for treatment of AIDS patients

Müller

Dobmeyer

et al. 1997

Cell Death Differ

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In the present study we demonstrate that flupirtine, an already clinically used, centrally acting, non-opiate analgesic agent, protects rat cortical neurons against HIV-gp120 induced apoptotic cell death. The drug was active at concentrations between 1 and 10 mg/ml. Furthermore we show inhibition of in vitro induced apoptosis in human blood mononuclear cells, using flupirtine. Induced apoptosis in peripheral blood mononuclear cells from healthy individuals and HIV-1 infected patients was reduced to approximately 50% after in vitro preincubation with flupirtine at concentrations between 0.1 and 10 mg/ml. The anti-apoptotic effect of flupirtine was restricted to CD3 + lymphocytes and in particular to CD4 + cells. Flupirtine does not affect uninduced apoptosis in human lymphocytes in vitro. The selective potential of flupirtine to reduce apoptosis without influencing uninduced apoptosis may qualify this compound as a potential drug in the therapy of HIV-1 infected patients.

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Apoptosis and Programmed Cell Death in Health and Disease

Cited by 123 publications

References 265 publications

Fluorescent-conjugated polymer superquenching facilitates highly sensitive detection of proteases

Fluorescent-conjugated polymer superquenching facilitates highly sensitive detection of proteases

Cytotoxicity of Two Triterpenoids from Nigella glandulifera

Flupirtine protects both neuronal cells and lymphocytes against induced apoptosis in vitro: Implications for treatment of AIDS patients

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