The decreased percentage of cells expressing IL-2 and IFN-gamma in conjunction with an increased proportion of IL-4- and IL-10-producing cells among the CD4+ T cells in HIV-1-infected individuals demonstrate a Th1 to Th2 cytokine shift in the course of HIV infection on a single cell level. There was no evidence of a Th1 to Th0 cytokine shift. In addition to the loss of CD4+ T cells in HIV infection, the qualitative changes of Th1/Th2 cytokine expression may serve as a marker for progressive failure of cell-mediated immunity.

No abstract

Summary. Dysregulation of T-cell receptor (TCR) ab bearing lymphocytes and an increase in Vd1þ gd T cells are typical features of HIV-1 infection. However, the role of gd T cells remains unclear. Therefore, peripheral blood mononuclear cells (PBMC) of 103 HIV-1-infected patients were investigated with respect to expression of Vd1. These results were compared to the Vd1 expression of bone marrow mononuclear cells (BMMC). In contrast to healthy controls, Vd1