Apoptosis in Rat Cornea After In Vivo Exposure to Ultraviolet Radiation at 300 nm

Kronschläger, Martin; Talebizadeh, Nooshin; Yu, Zhu Liang; Meyer, Linda; Löfgren, Stefan

doi:10.1097/ico.0000000000000498

Cited by 14 publications

(19 citation statements)

References 26 publications

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“…For example, keratocyte apoptosis occurs in the corneal stroma as a result of injury or exposure to ultraviolet radiation [29][30][31]. Keratocytes are the precursor cells for myofibroblasts, which are responsible for successful wound repair and regeneration of normal corneal structure and function.…”

Section: Discussionmentioning

confidence: 99%

Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway

Charkoftaki¹,

Jester

Thompson

et al. 2018

The Ocular Surface

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Section: Discussionmentioning

confidence: 99%

Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway

Charkoftaki¹,

Jester

Thompson

et al. 2018

The Ocular Surface

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“…[9] Clinically, acute UV exposure can cause photokeratitis, which is analogous to a sunburn, producing haze, edema, and opacification from damage to the corneal epithelium, stroma, and endothelium. [10] Chronic UV exposure can lead to climatic droplet keratopathy, endothelial dysfunction, and tumors. [1011121314] However, the risk of developing a malignancy of the OS from sun-exposure is extremely low, around 0.3 per million in the United States.…”

Section: Ultraviolet Radiationmentioning

confidence: 99%

“…[10] Chronic UV exposure can lead to climatic droplet keratopathy, endothelial dysfunction, and tumors. [1011121314] However, the risk of developing a malignancy of the OS from sun-exposure is extremely low, around 0.3 per million in the United States. Moreover, the majority of cases do not arise from or involve the corneal epithelium but develop in the conjunctiva.…”

Section: Ultraviolet Radiationmentioning

confidence: 99%

Invisible shield: Review of the corneal epithelium as a barrier to UV radiation, pathogens, and other environmental stimuli

Bashir¹,

Seykora²,

Lee³

2017

J Ophthalmic Vis Res

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The ocular surface is comprised of the cornea and conjunctiva, which are structures that not only protect the eye but also enable vision. The corneal epithelium is the most superficial layer of the cornea, and therefore first line of defense against external assaults. Damage to this highly specialized structure could lead to vision loss, making it an important structure to investigate and understand. Here, we conducted a search of the current literature on the mechanisms the corneal epithelium has adapted against three frequent insults: UV-radiation, pathogens, and environmental assaults. This review systematically examines the corneal epithelium's response to each assault in order to maintain its role as an invisible shield. The goal of this review is to provide insight into some of the critical functions the corneal epithelium performs that may be valuable to current regenerative studies.

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“…An elegant study by Notara et al, utilising cultured limbal stem cells, proved ex vivo that UVB irradiation leads to loss of function of limbal epithelial cells, fibroblasts, epithelial progenitor cells, and the ability to form holoclones [32]. Animal studies examining UV damage at the microstructural level, have also shown ex vivo damage of the cornea and the conjunctiva [33][34][35][36]. However, animal eyes, particularly the ocular surface, are generally more robust to environmental factors, and such experimental studies cannot be replicated using humans.…”

Section: Discussionmentioning

confidence: 99%

Damage of the ocular surface from indoor suntanning—Insights from in vivo confocal microscopy

Grupcheva

Radeva

Grupchev

et al. 2021

Contact Lens and Anterior Eye

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To evaluate the ocular surface at the microstructural level of adults who habitually undertake indoorsuntanning utilising in vivo confocal microscopy. Methods: Participants were prospectively recruited and enrolled into either а study group (n = 75) with a history UV indoor tanning, or a control group (n = 75) with no prior history of artificial tanning. The study group participated in voluntary tanning sessions performed with standard equipment and maintained their usual routine for eye protection. Slit lamp biomicroscopy and in vivo confocal microscopy were performed at baseline before undertaking a series of suntanning sessions (10 sessions of 10 min duration over a 15 day period), within three days after the last session, and four weeks after the last session. Control group participants were examined at baseline and 8 weeks later and did not participate in tanning sessions. Results: All participants were female with a mean age of 25 ± 4 years and 24 ± 4 years in the study and control groups, respectively. No clinically significant changes were observed in either group over time using slit lamp biomicroscopy (all p ≥ 0.05), however, statistically significant differences were observed between the study and the control group for all corneal layers imaged using confocal microscopy (all p ≤ 0.03). Characteristic cystic conjunctival lesions with dark centres and bright borders were observed in 95% of the study group before and in 100% after the suntanning sessions. Conclusion: Indoor suntanning resulted in statistically significant microstructural changes in the cornea and the bulbar conjunctiva that are undetectable with slit lamp biomicroscopy.

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Apoptosis in Rat Cornea After In Vivo Exposure to Ultraviolet Radiation at 300 nm

Cited by 14 publications

References 26 publications

Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway

Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway

Invisible shield: Review of the corneal epithelium as a barrier to UV radiation, pathogens, and other environmental stimuli

Damage of the ocular surface from indoor suntanning—Insights from in vivo confocal microscopy

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