Apoptosis-inducing effect of Jinke on Molt-4 cells and its mechanism

Zhu, Zhenchuang; Deng, Yu; Yu, Dongdong; Wu, Xiao; Li, Xiaolan; Tao, Deding; Hu, Jian; Gong, Jianping

doi:10.1007/s10330-008-0067-2

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…To this date, T. robiniophila has been made into granulated powder for clinical application. For instance, Jinke, Chinese national first class new medicine, has been extensively used to treat carcinoma in clinic and reported to induce Molt-4 cells apoptosis recently (Zhu et al 2008). It has been reported that PS-T prevented and suppressed hepatocellular carcinoma, and could enhance host immunity and cellular immunity (Chen et al 2004).…”

Section: Introductionmentioning

confidence: 98%

In vivo immunostimulatory and tumor-inhibitory activities of polysaccharides isolated from solid-state-cultured Trametes robiniophila Murrill

Jia

Wang

et al. 2009

World J Microbiol Biotechnol

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Crude polysaccharides extracted from successfully solid-state-cultured Trametes robiniophila (PST) showed cellular immunomodulatory and tumor-inhibitory activities in vivo. The different concentration of PST (100, 200, 400 mg kg -1 body weight) significantly enhanced immunity response in mice burden with Sarcoma 180 (S180) solid tumor. The results indicated that PST not only increased the macrophage phagocytosis and NO production, but also promoted lymphocyte proliferation and natural killer cell activity, and PST administration significantly inhibited tumor growth with the rate up to 60.9%. Interestingly, the most effective polysaccharides dosage on enhancing cellular immunity and inhibiting tumor was 200 mg kg -1 body weight each day. In conclusion, in vivo immunostimulatory and tumor-inhibitory activities of PST showed a non-dose-dependent manner, and suggested it could be used potentially in medicinal application.

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Section: Introductionmentioning

confidence: 98%

In vivo immunostimulatory and tumor-inhibitory activities of polysaccharides isolated from solid-state-cultured Trametes robiniophila Murrill

Jia

Wang

et al. 2009

World J Microbiol Biotechnol

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show abstract

“…As an anticarcinogenic medicine, T. robiniophila has been used for the treatment of liver cancer with satisfactory results. Accumulated evidences suggest that the antitumor mechanism of Huaier may be associated with the inhibition of the growing of endothelial cells, interference with tumor angiogenesis (Xu et al 2003), system immune activation (Chen et al 2004;Jia et al 2009), induction of tumor cell apoptosis, and suppression of tumor cell proliferation (Zhu et al 2008). Irrespective of its efficient treatment for liver cancer, so far, there is no information available about the anticancer effects of Huaier on cholangiocarcinoma, and its underlying mechanism of action is still largely unknown.…”

Section: Anticancer/antitumor Potentialmentioning

confidence: 99%