Structure and Bioactivities of Fungal Polysaccharides

Khan, Muhammad Saeed; Zhang, Xuewu; You, Lijun; Fu, X.; Abbasi, Arshad Mehmood

doi:10.1007/978-3-319-03751-6_28-1

Cited by 3 publications

(4 citation statements)

References 84 publications

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“…Following CVG stimulation, the Th2-associated cytokines (IL-4, -6 and principally-10) (18,19) and Th17 cytokine (IL-17A) (19) were produced at notably higher levels compared with the Th1-associated cytokines (IL-2 and IFN-γ) (14). These results indicate that CVG may promote the secretion of cytokines from T cells, particularly of cytokines associated with Th2-mediated humoral immunity and Th2 proliferation and differentiation such as IL-4 and -6 (14). Thus, CVG may enhance Th2-mediated humoral immunity, as an established prerequisite for improved adaptive immunity (18).…”

Section: Resultsmentioning

confidence: 99%

“…IL-10 inhibits nuclear factor-κB signaling, a key inflammatory pathway, and thus downregulates proinflammatory cytokine expression in its role as an antitumor cytokine (14). Furthermore, in previous studies, IL-10 therapy inhibited colon inflammation and carcinoma, while its deficiency in an experimental murine animal model resulted in bacteria-induced carcinogenesis (30,31).…”

Section: Discussionmentioning

confidence: 96%

“…Thus, despite increased levels of IL-10 in numerous cancers and its association with poor prognosis (30), CVG may exert its apparent anticancer effects through the beneficial immunomodulatory functions of IL-10, among other mechanistic pathways. The beneficial effect of IL-10, as a potent anti-inflammatory cytokine produced by monocytes, mast cells, macrophages and dendritic cells, has been reported in a number of cancers, including melanoma and breast and ovarian cancers, and may occur through its suppression of major histocompatibility complex-I activity and induction of NK-mediated tumor lysis (14,18,19). Furthermore, IL-10 has been identified to suppress the growth and metastasis of tumors by inhibiting the production of angiogenic factors (19,31).…”

Section: Discussionmentioning

confidence: 99%

“…Among the diverse glucans present in mushrooms are α-glucans, which have also been identified in parasitic and bacterial cell communities (14). Notably, glucans have been indicated to increase the secretion of a range of key cytokines, including interleukins (ILs) and interferons (IFNs) (15,16).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Coriolus versicolor glucan on the stimulation of cytokine production in sarcoma-180-bearing mice

et al. 2017

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Abstract. Coriolus versicolor (CV) contains high levels of bioactive compounds, including the glucan (1→6)-α-D-glucopyranosyl. However, there is a lack of data regarding the potential effect of this CV glucan (CVG) on the stimulation of cytokine production. The present study evaluated the effect of CVG on the stimulation of cytokine production in sarcoma-180-bearing mice. Mice were treated with three doses of CVG (40, 100 or 200 mg/kg body weight) for nine days, after which serum levels of cytokines, namely interleukin (IL)-2, -4, -6, -10, -17A and interferon (IFN)-α and -γ, were investigated by ELISA. CVG significantly promoted the secretion of IL-2, -4, -6, -10, -17A and IFN-α and -γ at the doses of 100 (P<0.05) and 200 (P<0.01) mg/kg, but not at 40 mg/kg (P>0.05), when compared with cyclophosphamide treatment, as a positive control. Additionally, cytokine production associated with T helper (Th)2 and Th17 cells was enhanced compared with that of Th1 cytokines, and the immunomodulatory function of CVG appeared to be IL-10-dependent. These results demonstrate that CVG may stimulate the production of cytokines and serve as a Th2/IL-10-dependent immunomodulator, and thus has promise in supporting cancer therapies.

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