Apoptosis-mediated proliferation inhibition of human colon cancer cells by volatile principles of Citrus aurantifolia

Chemical Composition and Antiproliferative Activity of Supercritical CO2 Extracts from Citrus Fruits

“…Other constituents of fruits also contribute to the cytotoxic activity such as α-terpineol, dodecanoic acid, geraniol, and auraptene (Hassan et al, 2010;Lee et al, 2001;Ueda et al, 2002;Murakami et al, 1997). Several volatile compounds in the fruit extracts are suspected to be responsible for the antiproliferative activity, which agreed with the literature (Patil et al, 2009). Nevertheless, although these anticancer compounds were common among the tested extracts, others showed less of an antiproliferative effect on cancer cells, suggesting that despite the importance of these compounds, the presence of other minor components in the extracts provide synergistic or antagonistic effects and determine the antiproliferative activity against cancer cells.…”

The Anti-proliferative Effects of a Palm Oil-derived Product and Its Mode of Actions in Human Malignant Melanoma MeWo Cells

“…The Caspase-Glo-3/7 assay is based on the amount of luminescence released due to cleavage of luminogenic caspase-3/7 substrate by the executioner caspase-3 and -7. Caspase-3 and -7 are major executor class of caspases and are essential for the induction of DNA fragmentation as well as apoptosis 22 . The results presented in Fig.…”

Application of Alternative Technologies for Elimination of Artificial Colorings in Alcoholic Beverages Produced by <i>Citrus medica</i> and Potential Impact on Human Health

“…Terpenes, such as limonene, have been also shown to prevent mammary, liver, lung, gastric and other cancers [8][9][10]. These compounds have also been used to treat a variety of rodent cancers, including breast and pancreatic carcinomas.…”

“…The most important health benefits concerned remarkable antioxidant activity [7] and anticancer properties [5,8]. For example, limonene, the major component in the essential oils of citrus fruits, has demonstrated promising cancer preventive and therapeutic effects in preclinical model systems [9,10].…”

“…Therefore, the aim of the present work was 1) to examine potential elimination of chemical colorings by producing novel alcoholic beverages based on ethanolic extraction of citron components present in fruits and leaves, instead of the distillation method, which is currently used in Industrial practice and requires addition of chemical colorings, and 2) to investigate the volatile components of citron alcoholic beverages in association with potential antioxidant and anticancer properties, since recently a number of studies linked health benefits with citrus components [5,7,8].…”