Apoptosis on the move

Nowak-Śliwińska, Patrycja

doi:10.1007/s10495-018-1462-y

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…Apoptosis and necrosis are 2 important programmed cell death procedures with different effects on inflammation and immune responses ( 37 , 38 ). In apoptosis, cells shrink and disintegrate into apoptotic bodies that are usually engulfed by surrounding macrophages, leading to the noninflammatory nature of cell death ( 39 ). In necrosis, cells disrupt and release endogenous danger signals, resulting in inflammatory and immune responses ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor–Induced Caspase 3/Gasdermin E–Mediated Pyroptosis

Zhai

Yang

et al. 2022

Arthritis & Rheumatology

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To determine the role of gasdermin E (GSDME)-mediated pyroptosis in the pathogenesis and progression of rheumatoid arthritis (RA), and to explore the potential of GSDME as a therapeutic target in RA.Methods. The expression and activation of caspase 3 and GSDME in the synovium, macrophages, and monocytes of RA patients were determined by immunohistochemistry, immunofluorescence, and Western blot analysis. The correlation of activated GSDME with RA disease activity was evaluated. The pyroptotic ability of monocytes from RA patients was tested, and the effect of tumor necrosis factor (TNF) on caspase 3/GSDME-mediated pyroptosis of monocytes and macrophages was investigated. In addition, collagen-induced arthritis (CIA) was induced in mice lacking Gsdme, and the incidence and severity of arthritis were assessed.Results. Compared to cells from healthy controls, monocytes and synovial macrophages from RA patients showed increased expression of activated caspase 3, GSDME, and the N-terminal fragment of GSDME (GSDME-N). The expression of GSDME-N in monocytes from RA patients correlated positively with disease activity. Monocytes from RA patients with higher GSDME levels were more susceptible to pyroptosis. Furthermore, TNF induced pyroptosis in monocytes and macrophages by activating the caspase 3/GSDME pathway. The use of a caspase 3 inhibitor and silencing of GSDME significantly blocked TNF-induced pyroptosis. Gsdme deficiency effectively alleviated arthritis in a mouse model of CIA.Conclusion. These results support the notion of a pathogenic role of GSDME in RA and provide an alternative mechanism for RA pathogenesis involving TNF, which activates GSDME-mediated pyroptosis of monocytes and macrophages in RA. In addition, targeting GSDME might be a potential therapeutic approach for RA.

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Section: Discussionmentioning

confidence: 99%

Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor–Induced Caspase 3/Gasdermin E–Mediated Pyroptosis

Zhai

Yang

et al. 2022

Arthritis & Rheumatology

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“…In 2017, when Apoptosis turned adult, we took over as editors of Apoptosis and Springer-Nature generously agreed to select new cover art for every volume [1,2]. Authors are welcomed to suggest or submit images of their own work.…”

Section: From the Editors' Desksmentioning

confidence: 99%

A quarter century of Apoptosis

Nowak-Śliwińska

2021

Apoptosis

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“…Earlier work of Dr. Poon dealt with a novel mechanism in apoptosis of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure [4]. An impressive image of these beaded apoptopodia was on the cover of Apoptosis in 2018 [5]. This work also described how the membrane channel pannexin-1 is a key negative regulator of this process [6].…”

Section: From the Editors' Desksmentioning

confidence: 99%

Programmed death, cells on the last train to glory

Nowak-Śliwińska

2020

Apoptosis

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Cell death and the mechanisms of it are an increasing interest of researchers worldwide. This is best reflected by the number of scientific articles on cell death over the last 3 years (2017-2019), which increased by 64% as compared to the 3 years before (2014-2016) from 57,000 to 93,500 articles. Reports on apoptosis, necroptosis and ferroptosis are in the lead of these numbers. It is clear that this interest in programmed cell death is based on the fact that knowledge on this subject provides insight in biology in general, as well as in the processes of disease and resulting opportunities for therapeutic intervention.

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Apoptosis on the move

Cited by 7 publications

References 21 publications

Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor–Induced Caspase 3/Gasdermin E–Mediated Pyroptosis

Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor–Induced Caspase 3/Gasdermin E–Mediated Pyroptosis

A quarter century of Apoptosis

Programmed death, cells on the last train to glory

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