Apoptotic and proliferative status in HPV (+) and HPV (−) inverted papilloma patients. Correlation with local recurrence and clinicopathological variables

Giotakis, Evangelos; Gomatos, Ilias P.; Alevizos, Leonidas; Manolopoulos, Leonidas; Kataki, Agapi; Kandiloros, Dimitrios; Gorgoulis, Vassilis G.; Tsimaratou, Katerina; Konstantoulakis, Manousos; Yiotakis, Ioannis

doi:10.1016/j.prp.2012.03.009

Cited by 18 publications

(12 citation statements)

References 20 publications

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“…It has been demonstrated that HPV infection plays a critical role in the pathogenesis of SNIP . However, the exact functional mechanism of HPV infection in SNIP has still not been fully unraveled.…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that HPV infection plays a critical role in the pathogenesis of SNIP. 17 However, the exact functional mechanism of HPV infection in SNIP has still not been fully unraveled. Accumulating evidence has shown that stathmin plays a critical role in the tumor carcinogenesis, proliferation, and progression of a variety of human malignancies, including pancreatic, esophageal, gastric, urothelial, hepatocellular, and oral carcinomas and has been proven as a valuable prognostic marker in patients who suffer from these cancers.…”

Section: Discussionmentioning

confidence: 99%

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Roles of human papillomavirus infection and stathmin in the pathogenesis of sinonasal inverted papilloma

Lin

Xiong

2015

Head Neck

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Roles of human papillomavirus infection and stathmin in the pathogenesis of sinonasal inverted papilloma

Lin

Xiong

2015

Head Neck

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“…The expression of proliferation and apoptotic markers including PCNA, bax, cytochrome C and caspase-8 in IP and nasal polyps, has also been studied. 35 While PCNA, a proliferation marker, was more frequently observed in IP than nasal polyps, apoptotic markers caspase-8 and bax were less frequently observed in IP compared with nasal polyps. These results indicate that dysregulation of cell proliferation and apoptotic factors are likely involved in IP development.…”

Section: Influence Of Chronic Inflammationmentioning

confidence: 94%

Etiology of sinonasal inverted papilloma: A narrative review

Wang

Noel

2017

World j. otorhinolaryngol.-head neck surg.

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ObjectiveSinonasal inverted papilloma (IP) is a benign and uncommon tumor of the nasal cavity and paranasal sinuses with a tendency for recurrence and even malignant transformation. Though the morphology and clinical behavior of this lesion has been well described, its etiology remains controversial.MethodsComputerized searches were performed in PubMed, Scopus, and Google scholar through May 2015. In this review, etiologic factors including human papilloma virus (HPV), Epstein–Barr virus (EBV), cell cycle related proteins and angiogenic factors, occupational and environmental exposures, and chronic inflammation, will be discussed.ResultsMany studies indicate that HPV has been detected in a significant percentage of IP, while EBV has not been shown to be significantly associated. Certain cell cycle regulatory factors and angiogenic proteins contribute to the dysregulation of proliferation and apoptosis, and facilitate migration and tumor invasion. Occupational exposures, such as welding and organic solvents, have been implicated, and smoking seems more critical to recurrence and dysplasia rather than initial IP occurrence. Chronic inflammation may also have a causative relationship with inverted papilloma, but the mechanism is unclear.ConclusionsThough etiology of sinonasal IP remains controversial, the studies reviewed here indicate a role for viral infection, cell cycle and angiogenic factors, environmental and occupational exposure, and chronic inflammation. Further study on etiologic factors is necessary for clinical guidance and therapeutic targets.

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“…The malignant transformation rate is 5–10% and many of them are synchronous presenting with squamous cell carcinoma [ 4 ]. PCNA (proliferating cell nuclear antigen) acts as an antigen expression in the cell nuclei in the phase of DNA synthesis during cell cycle and considers the cancer prognosis, but the relationship to IP is still controversial [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation

Tsou

Huang

Wang

et al. 2014

BioMed Research International

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The recurrent sinonasal inverted papilloma (IP) could be transformed to sinonasal squamous cell carcinoma. We use protein expression patterns by immunohistochemical method to see whether the expression of p53, p16, p21, and p27 belongs to cell-cycle-regulators and PCNA (proliferating cell nuclear antigen) and Ki-67 the proliferation markers in sixty patients with sinonasal inverted papilloma, and 10 of them with squamous cell carcinoma transformation. Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed. No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expression was correlated to sinonasal IP malignant transformation by multivariate survey. However, we found elevated PLUNC expression in IPs with multiple recurrences. Finally, we found that PCNA, p27 may interact with CDK1 which promote IP cell proliferation and correlate to sinonasal squamous cell carcinoma. Ki-67 could work throughout the cell cycles to cause malignant transformation. In conclusion, this is a first study showing the correlation of Ki-67, PCNA interacted with CDK1 might lead to malignant transformation. Elevated PLUNC expression in the sinonasal IPs was related to multiple recurrences in human.

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Apoptotic and proliferative status in HPV (+) and HPV (−) inverted papilloma patients. Correlation with local recurrence and clinicopathological variables

Cited by 18 publications

References 20 publications

Roles of human papillomavirus infection and stathmin in the pathogenesis of sinonasal inverted papilloma

Roles of human papillomavirus infection and stathmin in the pathogenesis of sinonasal inverted papilloma

Etiology of sinonasal inverted papilloma: A narrative review

Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation

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