Apoptotic cell-mimicking gold nanocages loaded with LXR agonist for attenuating the progression of murine systemic lupus erythematosus

Xu, Nan; Li, Jun; Gao, Yujie; Zhou, Nan; Ma, Qiuying; Wu, Michael; Zhang, Yamin; Sun, Xiaoyan; Xie, Jun; Shen, Guanxin; Yang, Ming; Tu, Qiming; Xu, Xiaowei; Zhu, Jintao; Tao, Juan

doi:10.1016/j.biomaterials.2019.01.034

Cited by 31 publications

(21 citation statements)

References 39 publications

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“…This hybrid system is dependent on temperature, pH, and light activation and therefore has site-specific drug delivery functions and is safe in cells [21]. Some studies have demonstrated its therapeutic effects on immune cells such as dendritic cells and macrophages [22,23].…”

Section: Introductionmentioning

confidence: 99%

Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting

et al. 2020

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Coenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble antioxidant. Although CoQ10 has not been approved as medication by the Food and Drug Administration, it is widely used in dietary supplements. Some studies have shown that CoQ10 has anti-inflammatory effects on various autoimmune disorders. In this study, we investigated the anti-inflammatory effects of liposome/gold hybrid nanoparticles encoded with CoQ10 (LGNP-CoQ10). Both CoQ10 and LGNP-CoQ10 were administered orally to mice with collagen-induced arthritis (CIA) for 10 weeks. The inflammation pathology of joint tissues of CIA mice was then analyzed using hematoxylin and eosin and Safranin O staining, as well as immunohistochemistry analysis. We obtained immunofluorescence staining images of spleen tissues using confocal microscopy. We found that pro-inflammatory cytokines were significantly decreased in LGNP-CoQ10 injected mice. Th17 cell and phosphorylated STAT3-expressed cell populations were also decreased in LGNP-CoQ10 injected mice. When human peripheral blood mononuclear cells (PBMCs) were treated with CoQ10 and LGNP-CoQ10, the IL-17 expression of PBMCs in the LGNP-CoQ10-treated group was significantly reduced. Together, these results suggest that LGNP-CoQ10 has therapeutic potential for the treatment of rheumatoid arthritis.

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Section: Introductionmentioning

confidence: 99%

Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting

et al. 2020

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“…For instance, atherosclerotic plaque-targeting nanoparticles encapsulating LXR ligands upregulate LXR target genes (including cholesterol efflux genes) and downregulate proinflammatory mediators in macrophages in vitro and reduce macrophage frequency and promote regression in plaques without adverse effects on hepatic lipid metabolism in vivo (124)(125)(126)(127)(128). Similar strategies show promise at inhibiting inflammation (129), promoting resolution of inflammation (130) and improving apoptotic cell clearance through phagocytosis using gold nanocages loaded with LXR ligands (131). These recent advances could expedite the path to clinical translation for LXR agonists.…”

Section: Therapeutic Activation Of Lxrsmentioning

confidence: 99%

Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors?

et al. 2021

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Multiple sclerosis (MS) is a chronic neurological disease driven by autoimmune, inflammatory and neurodegenerative processes leading to neuronal demyelination and subsequent degeneration. Systemic lipid metabolism is disturbed in people with MS, and lipid metabolic pathways are crucial to the protective process of remyelination. The lipid-activated transcription factors liver X receptors (LXRs) are important integrators of lipid metabolism and immunity. Consequently, there is a strong interest in targeting these receptors in a number of metabolic and inflammatory diseases, including MS. We have reviewed the evidence for involvement of LXR-driven lipid metabolism in the dysfunction of peripheral and brain-resident immune cells in MS, focusing on human studies, both the relapsing remitting and progressive phases of the disease are discussed. Finally, we discuss the therapeutic potential of modulating the activity of these receptors with existing pharmacological agents and highlight important areas of future research.

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“…The unique optical properties of gold-silver alloy nanoparticles (AuAg) make it widely used in PT [ 19 , 20 ]. In addition to its photothermal effect, AuAg has a hollow inside and is porous outside, a structure suitable for loading drugs; therefore, it is widely used in tumor treatment [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation

Ran

Qiu

et al. 2021

Bioactive Materials

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The increase in the number of resistant bacteria caused by the abuse of antibiotics and the emergence of biofilms significantly reduce the effectiveness of antibiotics. Bacterial infections are detrimental to our life and health. To reduce the abuse of antibiotics and treat biofilm-related bacterial infections, a biomimetic nano-antibacterial system, RBCM-NW-G namely, that controls the release of antibiotics through near infrared was prepared. The hollow porous structure and the high surface activity of nanoworms are used to realize antibiotic loading, and then, biomimetics are applied with red blood cell membranes (RBCM). RBCM-NW-G, which retains the performance of RBCM, shows enhanced permeability and retention effects. Fluorescence imaging in mice showed the effective accumulation of RBCM-NW-G at the site of infection. In addition, the biomimetic nanoparticles showed a longer blood circulation time and good biocompatibility. Anti-biofilm test results showed damage to biofilms due to a photothermal effect and a highly efficient antibacterial performance under the synergy of the photothermal effect, silver iron, and antibiotics. Finally, by constructing a mouse infection model, the great potential of RBCM-NW-G in the treatment of in vivo infections was confirmed.

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Apoptotic cell-mimicking gold nanocages loaded with LXR agonist for attenuating the progression of murine systemic lupus erythematosus

Cited by 31 publications

References 39 publications

Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting

Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting

Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors?

Erythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation

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