Erythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation

Abstract

The increase in the number of resistant bacteria caused by the abuse of antibiotics and the emergence of biofilms significantly reduce the effectiveness of antibiotics. Bacterial infections are detrimental to our life and health. To reduce the abuse of antibiotics and treat biofilm-related bacterial infections, a biomimetic nano-antibacterial system, RBCM-NW-G namely, that controls the release of antibiotics through near infrared was prepared. The hollow porous structure and the high surface activity of nanoworms are used to realize antibiotic loading, and then, biomimetics are applied with red blood cell membranes (RBCM). RBCM-NW-G, which retains the performance of RBCM, shows enhanced permeability and retention effects. Fluorescence imaging in mice showed the effective accumulation of RBCM-NW-G at the site of infection. In addition, the biomimetic nanoparticles showed a longer blood circulation time and good biocompatibility. Anti-biofilm test results showed damage to biofilms due to a photothermal effect and a highly efficient antibacterial performance under the synergy of the photothermal effect, silver iron, and antibiotics. Finally, by constructing a mouse infection model, the great potential of RBCM-NW-G in the treatment of in vivo infections was confirmed.

Engineering Robust Ag‐Decorated Polydopamine Nano‐Photothermal Platforms to Combat Bacterial Infection and Prompt Wound Healing

“…All bacteria were stained by SYTO9 and emitted green fluorescence, whereas the dead bacteria were labeled by PI and emitted red fluorescence. [ 38 ] It can be seen in Figure 4H and Figures S14 and S15 (Supporting Information) that both S. aureus and E. coli treated by PBS presented noticeable green fluorescence, and only a few bacteria were labeled with red fluorescence. In contrast, some red fluorescence appeared in the CG hydrogel treatment group.…”

Emerging Trends in Nanomaterials for Antibacterial Applications

“…This nanoantibiotic was named RBCM-NW-G, and a summary of it preparation and treatment under 808-nm NIR laser irradiation is given in Figure 22 . 216 The biomimic nanocomposite revealed photothermal performance, effective accumulation in infected areas, and longer blood circulation times with good biocompatibility. With the synergistic effect of photothermal treatment, silver ions, and gentamicin, the prepared nanoantibiotic showed antibacterial potential highlighted in in vitro and mouse models against E. coli and S. aureus .…”

“…This nanoantibiotic was named RBCM-NW-G, and a summary of it preparation and treatment under 808-nm NIR laser irradiation is given in Figure 22. 216 The biomimic nanocomposite revealed photothermal performance, effective accumulation in…”

“…Reprinted from Bioact Mater, 6, Ran L, Lu B, Qiu H, et alErythrocyte membrane-camouflaged nanoworms with on-demand antibiotic release for eradicating biofilms using near-infrared irradiation. 2956-2968, Copyright 2021, with permission from KeAi Publishing 216.…”

Iron oxide nanoparticles with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy

“…Due to the special composition and structure, extracellular polymer has a strong protective effect on the bacteria encapsulated in the biofilm. It is usually more difficult to eradicate the formed bacterial biofilm than to kill the planktonic bacteria, which is a great challenge for the clinical treatment of biofilm-related infections [ 37 , 38 ]. The presence of bacterial biofilm is one of the main causes of bacterial drug resistance, leading to many chronic bacterial infection diseases [ 9 , 33 ].…”