Apoptotic effect of <i>Polygonum Cuspidatum</i> in oral cancer cells through the regulation of specificity protein 1

Ja, Shin; Shim, Jung‐Hyun; Jg, Jeon; Kh, Choi; Es, Choi; Np, Cho; Sd, Cho

doi:10.1111/j.1601-0825.2010.01710.x

Cited by 43 publications

(29 citation statements)

References 30 publications

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“…Several studies found that Sp1 regulates survivin as its downstream target in various cancer cell lines (37,(39)(40)(41). We also found that HESO significantly decreased survivin, suggesting that the downregulation of Sp1 by HESO in HN22 cells resulted in a decrease of survivin expression.…”

Section: Discussionsupporting

confidence: 55%

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Apoptotic effect of hot water extract of Sanguisorba officinalis L. in human oral cancer cells

Shin

Kim²,

Kwon

et al. 2012

Oncology Letters

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Abstract. Sanguisorba officinalis L. has been used in traditional Asian medicine to treat diseases including diarrhea, chronic intestinal infections, duodenal ulcers and bleeding. This study examined the antiproliferative effects and apoptotic activity of hot water extract of S. officinalis L. (HESO) on HSC4 and HN22 human oral cancer cells. The effects of HESO were evaluated by the 3-(4,5-dimethylthiazol-20yl)-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium (MTS) assay, 4'-6-diamidino-2-phenylindole (DAPI) staining and western blot analysis. HESO was found to inhibit cell growth and induce apoptosis in HSC4 and HN22 oral cancer cells. HESO downregulated myeloid cell leukemia-1 (Mcl-1) in HSC4 cells and was associated with the activation of Bak, resulting in Bak oligomerization on the mitochondrial outer membrane. HESO did not alter Mcl-1 expression in HN22 cells, but it decreased Sp1 expression. The downregulation of Sp1 by HESO in HN22 cells resulted in a decrease in survivin, a downstream target protein of Sp1. These results suggested that HESO inhibited the growth of oral cancer through either Mcl-1 or Sp1, indicating that HESO may serve as a potential drug candidate against oral cancer.

show abstract

Section: Discussionsupporting

confidence: 55%

“…Previous studies reported that Sp1 is overexpressed in many human tumor and cancer cell lines (35,36). Furthermore, we reported that downregulation of Sp1 induces apoptosis in cervical, prostate and oral cancer cells (37)(38)(39). Thus, we examined whether HESO-induced apoptosis was associated with the Sp1 protein.…”

Section: Discussionmentioning

confidence: 99%

Apoptotic effect of hot water extract of Sanguisorba officinalis L. in human oral cancer cells

Shin

Kim²,

Kwon

et al. 2012

Oncology Letters

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“…Withania somnifera extract also reduces the overall occurrence of oral tumors by increasing antioxidant activity (21,22). Recently, it has been demonstrated that Polygonum cuspidatum induces apoptotic cell death in oral cancer cells through the regulation of specificity protein 1 (23). This clearly suggests that the extracts of natural products have anticarcinogenic activities against oral cancer.…”

Section: Discussionmentioning

confidence: 93%

Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells

Shin

Kim²,

Hong

et al. 2012

Oncology Letters

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Abstract. Since the 5-year survival rate of oral cancer remains low, more effective and non-toxic therapeutic and preventive strategies are required. Certain natural products possess anticancer properties. The present study investigated the effects of the methanol extracts of Codonopsis lanceolata (MECI) and Tricholoma matsutake (METM) and identified the molecular target in HSC-2 human oral cancer cells. The results revealed that MECI and METM inhibited growth and induced apoptosis, as demonstrated by poly (ADP-ribose) polymerase (PARP) cleavage and nuclear condensation and fragmentation. The compounds also increased Bak protein expression, while Bax, Bcl-XL and Mcl-1 were not affected. The results of the present study show that MECI and METM induce apoptosis to inhibit tumor growth of HSC-2 cells by modulating the Bak protein and suggest that Codonopsis lanceolata and Tricholoma matsutake are potential anticancer drug candidates for oral cancer.

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“…P. cuspidatum extract contains alkaloids, phenolics, and sterol/terpenes and induces biological activities such as anti-inlammation, antioxidation, and anticancer efects [38]. In A549 and H1650 cells, the ethanol and ethyl acetate extracts of P. cuspidatum can eliminate 1,1-diphenyl-2-hydrazyl (DPPH) and hydroxyl radicals.…”

Section: Reactive Oxygen Species (Ros) and Lung Cancer Therapymentioning

confidence: 99%

Antitumor Effect of Natural Product Molecules against Lung Cancer

Zhong¹,

Qin²,

Chen³

et al. 2017

A Global Scientific Vision - Prevention, Diagnosis, and Treatment of Lung Cancer

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Lung cancer treatment remains diicult because of multidrug resistance and adverse efects, and natural product molecules show powerful activity in lung cancer with few side efects. The molecular targets and eicacy of natural product molecules remain unclear. We described the molecular regulation of natural product molecules with antitumor activities, the antilung cancer activities and the clinical trials for lung cancer treatment of natural product molecules. The results support the updated systemic information on the use of natural product molecules to prevent cancer progression and their constituents for lung cancer treatment.

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Apoptotic effect of Polygonum Cuspidatum in oral cancer cells through the regulation of specificity protein 1

Abstract: The results from this study strongly suggest that MEPC, its fraction, and Emodin may be potential bioactive materials to cause apoptosis mechanism via the down-regulation of Sp1 in oral cancer cells.

Cited by 43 publications

References 30 publications

Apoptotic effect of hot water extract of Sanguisorba officinalis L. in human oral cancer cells

Apoptotic effect of hot water extract of Sanguisorba officinalis L. in human oral cancer cells

Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells

Antitumor Effect of Natural Product Molecules against Lung Cancer

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