Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells

Cardiotoxin III‐induced apoptosis is mediated by Ca2+‐dependent caspase‐12 activation in K562 cells

“…ER stress usually caused Ca 2+ release and induced μ-calpain-mediated activation of caspase-12 [17,20,23]. However, contrary to our expectation, μ-calpain did not change in our study (Figure 2), suggesting that caspase-12 activation in apoptotic K562 cells is independent on the route of μ-calpain activation.…”

“…Intracellular calcium increment causes the activation of μ-calpain followed by caspase-12 activation. The calpain/caspase-12-dependent apoptosis was first identified in amyloid-β neuronal cell death [1], and the evidence for the same pathway was also proved in other cell lines including hepatocellular carcinoma, cardiac myoblasts, and breast cancer cells [17,20,21]. In the present study, CTX III was found to heighten calcium release, triggering the resulting extracellular calcium influx ( Figures 1A and 1B).…”

Anticancer Effects of Taiwanofungus camphoratus Extracts, Isolated Compounds and its Combinational use

“…Furthermore, the mitochondrial apoptotic pathway amplified the calpain pathway by Bid and Bax interaction and Ca 2þ translocation. 23 …”

Macrophage Mediated Anti-Proliferation Effects ofAnthodia camphorataNon-Polysaccharide Based Extracts on Human Hepatoma Cells

“…8,9) In addition, crude methanol extracts of A. camphorate display anti-tumor activity through upregulation of Fas, release of cytochrome c, activation of caspase-3, -8, and -9, and cell-cycle arrest of G0/G1 in several hepatoma cell lines. 4,8,10,11) Despite the anti-tumor effects of purified polysaccharides of A. camphorata that have been reported, 12) our previous study found that extracts of A. camphorata from liquid-state and solid-state cultures did not show remarkable anti-proliferative effects on hepatoma cells, although extracts of solid-state cultures in high concentrations did display effects. 13) Hence it might be remain to be clarified what the mechanisms of the anti-tumor effects of various extracts of A. camphorata.…”