Macrophage Mediated Anti-Proliferation Effects of<i>Anthodia camphorata</i>Non-Polysaccharide Based Extracts on Human Hepatoma Cells

Chang, Chia‐Yu; Cheng, Tain‐Junn; Chang, Fang‐Rong; Wang, Hsien-Yi; Li, Shunlai; Huang, Li-Chi; Chen, Yu‐Chun; Tsai, Wan‐Chen; Huang, Chun Che; Cheng, Chia-Hui; Lee, Guo-Yang; Shyue, Shiang-Wei; Chen, Yi-Peng; Lin, Kao‐Chang; Chuu, Jiunn-Jye

doi:10.1271/bbb.100559

Cited by 10 publications

(9 citation statements)

References 37 publications

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“…Studies on Antrodia camphorata (AC) extracts showed that they can promote immune responses by exhibiting antileukemic activity in WEHI-3 leukemia BALB/c mice [83] and can activate the immunomodulation of macrophages in a human hepatoma cell model [84].…”

Section: Dna Damage and Apoptosis Biomarkers Activationmentioning

confidence: 99%

Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action

Popović¹,

Živković²,

Davidović³

et al. 2013

CTMC

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Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites. The increasing number of studies in the past few years revealed mushroom extracts as potent antitumor agents. Also, numerous studies were conducted on bioactive compounds isolated from mushrooms reporting the heteropolysaccharides, β-glucans, α-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as promising antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review. Findings with Antrodia camphorata and Ganoderma lucidium extracts and isolated compounds are presented, as being the most deeply studied previously.

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Section: Dna Damage and Apoptosis Biomarkers Activationmentioning

confidence: 99%

Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action

Popović¹,

Živković²,

Davidović³

et al. 2013

CTMC

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“…It is considered one of the most precious Chinese herbal medicines due to its rarity, and has been highly praised as a remedy for food poisoning, diarrhea, stomach ache, hypertension, itchy skin, and liver illness (Hsieh et al, 2015;Yang et al, 2017). In addition, many studies have shown that A. camphorata possesses a wide range of biological activities, including anti-cancer, anti-oxidation, lipid homeostasis, hepatoprotection, vasorelaxation, and immunomodulation (Chang et al, 2011;Geethangili and Tzeng, 2011;Wu et al, 2011;Liu et al, 2012;Tsai et al, 2015;Chang et al, 2017). In particular, liver protection is regarded as its most exceptional bioactive property.…”

Section: Introductionmentioning

confidence: 99%

Ergostatrien-3β-ol (EK100) from Antrodia camphorata Attenuates Oxidative Stress, Inflammation, and Liver Injury In Vitro and In Vivo

Chao¹,

Hsieh

Hsu³

et al. 2021

Prev. Nutr. Food Sci.

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Hepatic ischemia/reperfusion (IR) injury is a complication that occurs during liver surgery, whereby hepatic tissue is injured by oxygen deficiency during ischemia, then further damaged by a cascade of inflammatory and oxidative insults when blood is resupplied during reperfusion. Antrodia camphorata is an indigenous fungus in Taiwan and an esteemed Chinese herbal medicine with various bioactivities. This study examined the effect of ergostatrien-3β-ol (EK100), an active compound found in both the fruiting body and mycelia of A. camphorata , on IR injury pathologies in rats and cell models of oxidative and inflammatory stress. Male Sprague-Dawley rats were randomly assigned to receive a vehicle or 5 mg/kg EK100 prior to hepatic IR injury induced by 1 h ischemia followed by 24 h reperfusion, or a sham operation. RAW 264.7 murine macrophages and HepG2 hepatocytes were pretreated with EK100, then inflammation was induced with lipopolysaccharides in the former and oxidative stress was induced with hydrogen peroxide in the latter. EK100 decreased IR-induced elevation in serum levels of alanine aminotransferase and aspartate aminotransferase and lowered levels of the inflammatory cytokines tumor necrosis factor-α, interleukin (IL)-6, and IL-1β. In addition, EK100 significantly reduced hepatic mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2, as well as nitrite production and iNOS gene expression in both hepatocyte and macrophage cell lines. We demonstrated that EK100 exhibits potent protec-tion against hepatic IR injury, which may be used to design strategies to ameliorate liver damage during liver surgery.

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“…), BIRDS studies with the low molecular weight monomers suffer from short blood half-life and wide in-vivo distribution. To further improve the translational potential of BIRDS, we have conjugated thermodynamically stable macrocyclic p-SCN-Bn-DOTA to the amines on the surface of PAMAM dendrimers from generation 1 (G1) to generation 4 (G4) by using an isothiocyanatobenzyl group that achieves excellent synthesis yield (i.e., greater than 60%) and purities [ 50 ]. Dendrimer-based BIRDs agents demonstrated both acidic pH and temperature-sensing properties [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

“…To further improve the translational potential of BIRDS, we have conjugated thermodynamically stable macrocyclic p-SCN-Bn-DOTA to the amines on the surface of PAMAM dendrimers from generation 1 (G1) to generation 4 (G4) by using an isothiocyanatobenzyl group that achieves excellent synthesis yield (i.e., greater than 60%) and purities [ 50 ]. Dendrimer-based BIRDs agents demonstrated both acidic pH and temperature-sensing properties [ 50 ]. Therefore, we hypothesize that dendrimeric BIRDS agents have potential for a range of biomedical applications in quantitative theranostic imaging.…”

Section: Introductionmentioning

confidence: 99%

Dendrimer-Based Nanomedicine (Paramagnetic Nanoparticle, Nanocombretastatin, Nanocurcumin) for Glioblastoma Multiforme Imaging and Therapy

Ali¹

2021

NACS

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Macrophage Mediated Anti-Proliferation Effects ofAnthodia camphorataNon-Polysaccharide Based Extracts on Human Hepatoma Cells

Cited by 10 publications

References 37 publications

Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action

Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action

Ergostatrien-3β-ol (EK100) from Antrodia camphorata Attenuates Oxidative Stress, Inflammation, and Liver Injury In Vitro and In Vivo

Dendrimer-Based Nanomedicine (Paramagnetic Nanoparticle, Nanocombretastatin, Nanocurcumin) for Glioblastoma Multiforme Imaging and Therapy

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