Apoptotic-like death occurs through a caspase-independent route in colon carcinoma cells undergoing mitotic catastrophe

Abstract

We have examined the relationship between chemotherapy-induced mitotic catastrophe and cell death by apoptosis in both wild-type and p53 (-/-)

Cancer driver–passenger distinction via sporadic human and dog cancer comparison: a proof-of-principle study with colorectal cancer

“…2) and others (30) observed a drastic decrease in cell adhesion after 24 hours’ Taxol-treatment. The subsequent expression increase at 48 hours (Fig.…”

“…We treated HCT116, a near diploid human CRC line, with Taxol (Paclitaxel), a anticancer drug shown to stabilize microtubules, block the progression of cell cycle and trigger cancer cell death (29, 30). For PCGs, we did not observe any significant changes in gene expression on the whole at different Taxol concentrations (10nM, 20nM, and 80nM) and treatment times (24 hours and 48 hours) (Fig.…”

“…2) could possibly arise from the accelerated expression increment of cell cycle check-point genes, which arrested the cell cycle at G 2 /M checkpoints demonstrated by the significantly increased number of multinucleate cells observed at 48 hours as compared to 24 hours (see Fig. 2 and reference 30). Two DCGs, GADD45A and C1orf63 , are especially noteworthy, with their expression level increasing along with the Taxol concentration and incubation time, reaching 18-fold for C1orf63 and 14-fold for GADD45A at 80nM for 48 hours (Fig.…”

Overcoming resistance to mitochondrial apoptosis by BZML‐induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells

“…Importantly, the different functional forms of autophagy depend on the genetic background of cells, the microenvironment and the type of drug . Recently, other types of PCD, including necroptosis, MC and senescence, have been reported . MC, a p53‐independent apoptosis‐like cell death mode to against apoptosis resistance, has received more attention .…”

“…27,28 Recently, other types of PCD, including necroptosis, MC and senescence, have been reported. 10,[29][30][31] MC, a p53-independent apoptosis-like cell death mode to against apoptosis resistance, has received more attention. 10,30 Generally, drugs cannot fully kill cancer cells by only one type of PCD and, therefore, may easily induce multidrug resistance (MDR).…”