APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer’s disease

Walton, Julie; Wang, M.-X.

doi:10.1016/j.jinorgbio.2009.07.027

Cited by 140 publications

(93 citation statements)

References 65 publications

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“…Aluminum is a neurotoxic agent inducing the production of free radicals in the brain which may cause degenerative events and leads to formation of amyloid plaques and intraneuronal neurofilamentous aggregates that are tau positive in the brain of AD's patients [3].…”

Section: Introductionmentioning

confidence: 99%

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

et al. 2012

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This study aimed to elucidate the mechanisms of melatonin to manage neurological damage in Alzheimer's disease (AD) induced in ovariectomized rats. Forty adult female rats were enrolled in our study and were classified as; gonad intact control, ovariectomized control group, ovariectomized rats received melatonin, ovariectomized rats injected with AlCl 3 to induce AD and ADinduced rats treated with melatonin. Hydrogen peroxide (H 2 O 2 ), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), B cell lymphoma 2 (Bcl-2), brain derived neurotrophic factor (BDNF), acetylcholinesterase (AchE) and acetylcholine (Ach) were estimated in the brain tissues of the different groups. Treatment of AD-induced rats with melatonin produced marked improvement in the most studied biomarkers which was confirmed by histological investigation of the brain. In Conclusion, melatonin significantly ameliorates the neurodegeneration characteristic of AD in experimental animal model due to its antioxidant, antiapoptotic, neurotrophic and anti-amyloidogenic activities.

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Section: Introductionmentioning

confidence: 99%

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

et al. 2012

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“…In addition to leading to behavioral deficits, chronic exposure to dietary Al also leads to elevated levels of amyloid precursor protein (Walton and Wang, 2009). The consequences of chronic exposure to rather low levels of Al are difficult to isolate as they involve seeking evidence of an altered incidence of relatively common neurological diseases such as sporadic AD.…”

Section: Inflammation Is Pronounced In the Aging Brain And This Is Fmentioning

confidence: 99%

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

Bondy

2016

NeuroToxicology

208

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“…On the contrary, several studies have described its toxicity to the organic system although the mechanism is not fully understood [2][3][4][5][6][7]. The deleterious effect of this metal has been discussed for decades, the first time 40 years ago in an animal model [8] with several studies linking its presence in serum, cerebrospinal fluid (CSF) and central nervous system (CNS) to several neurodegenerative diseases (ND) such as Alzheimer´s disease (AD) [5,[9][10][11][12][13][14][15], and Amyotrophic Lateral Sclerosis (ALS) [12,[16][17][18][19][20][21][22][23]. There have been previous correlations of other metals metabolism and neurodegenerative diseases that encourage the study of aluminum in CNS and its contribution in neurodegeneration [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

High Aluminum Levels in Cerebrospinal Fluid of Patients with Neurodegenerative Diseases

Ruiz-Navarro¹

2017

MOJT

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Aluminum is the most abundant metal on earth. It is not known to have any biological metabolism; conversely it has a toxic effect that has been related to several damages including some neurodegenerative diseases. We sampledcerebrospinal fluid (CSF) in 141 patients with different chronic diseases, assessing the levels of aluminum contained. Our aim was to assess differences in aluminum levels between neuro-degenerative and non-neurodegenerative diseases. We found that patients with neurodegenerative diseases have higher levels of aluminum in cerebrospinal fluid than other non-degenerative diseases. These findings support previous descriptions of a chronic life-time aluminum accumulation in CSF as an environmental contributor to the Patophysiology of neurodegeneration. While aluminum and neurodegenerative diseases have already been correlated in previous studies, this report is, to the best of our knowledge, the first that directly correlates levels of aluminum in CSF with clinical status. Further investigation based on these findings has to be done in order to determine if this correlation is causality of specific diseases. In the meantime we encourage a wider sampling of aluminum (and other metals) in CSF in both patients with a neurodegenerative disease and healthy population as well as the analysis of aluminum-containing products.

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APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer’s disease

Cited by 140 publications

References 65 publications

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

High Aluminum Levels in Cerebrospinal Fluid of Patients with Neurodegenerative Diseases

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