Apparent diffusion coefficient for discriminating metastatic from non-metastatic lymph nodes in primary rectal cancer

Cho, Een Young; Kim, Seung Ho; Yoon, Junghee; Lee, Yedaun; Lim, Yun‐Jung; Kim, Seon-Jeong; Baek, Hye Jin; Eun, Choong Ki

doi:10.1016/j.ejrad.2013.08.007

Cited by 86 publications

(59 citation statements)

References 29 publications

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“…5 Although MRI has proven to be an invaluable tool for distinguishing RLN and cervical lymph node metastasis, 2,15,16 functional imaging, such as DWI, has been shown to facilitate diagnosis of lymph node metastasis in other malignant diseases. [17][18][19][20] Here, we evaluated the utility of DWI in differentiating metastatic from benign RLN in NPC, compared the accuracy of size-and ADC-based criteria in RLN metastasis and determined whether DWI would at all improve the diagnostic accuracy of RLN metastasis.…”

Section: Diagnosis Of Rln Metastasis With Dwimentioning

confidence: 99%

Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma

Xw²,

Zj³

et al. 2015

Dentomaxillofacial Radiology

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Objectives: To evaluate the diagnostic value of diffusion-weighted MRI for differentiating metastatic from non-metastatic retropharyngeal lymph nodes (RLNs) in patients with nasopharyngeal carcinoma (NPC). Methods: Untreated patients with NPC (n 5 145) were scanned with both morphological MRI and diffusion-weighted imaging (DWI). RLNs (n 5 335) were classified as metastatic on the basis of response to therapy as assessed on follow-up MRI. Morphological (short-and long-axial diameters) and functional [mean apparent diffusion coefficient (ADC) and minimum ADC values] parameters of the RLNs were derived from DWI and compared between metastatic and non-metastatic groups. A receiver operating characteristic curve and the area under the curve were used to evaluate the effectiveness of individual criteria and to generate threshold values to diagnose RLN metastases. Results: Statistically significant differences between metastatic and non-metastatic RLNs were found for all four parameters derived from DWI (p , 0.001). At threshold values, accuracies of the ADC-based criteria (0.938 and 0.965 for mean and minimum ADC values, respectively) were greater than that of size-based criteria (0.838 and 0.809 for short-and longaxial diameters). The minimum ADC value at the threshold of 0.89 3 10 23 mm 2 s 21 was the most effective of all parameters in differentiating metastatic from non-metastatic RLNs with the sensitivity of 95.7%, specificity of 95.1% and accuracy of 96.5%. Conclusions: DWI is feasible for differentiating metastatic RLNs from non-metastatic nodes in patients with NPC with high accuracy, and the minimum ADC derived from DWI could serve as a standard clinical marker for disease status. Dentomaxillofacial Radiology (2015Radiology ( ) 44, 20140126. doi: 10.1259 Cite this article as: Li H, Liu X-W, Geng Z-J, Wang D-L, Xie C-M. Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma. Dentomaxillofac Radiol 2015; 44: 20140126.

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Section: Diagnosis Of Rln Metastasis With Dwimentioning

confidence: 99%

Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma

Xw²,

Zj³

et al. 2015

Dentomaxillofacial Radiology

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“…DWI is used for diagnostic purposes in several abdominal organs and for urinary and pelvic cancer [4][5][6]. Furthermore review of the literature reveals successful results of the examination of the diffuse bowel pathologies with DWI imaging [18][19][20].…”

Section: Resultsmentioning

confidence: 99%

“…It is also a useful method for abdomen. In abdominal imaging, DW MRI has been mainly suggested for the characterization of colorectal cancer, lymph nodes, and metastases [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The utility of diffusion-weighted magnetic resonance imaging in differentiation of benign and malignant diffuse colon wall thickening

Koç¹,

Serhatlioğlu²

2017

Med-Science

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To examine the effectiveness of apparent diffusion coefficient (ADC) values in differentiation of benign bowel wall thickening and malignant diffuse scirrhous type's bowel wall thickening. Subject and Methods A total of 81 patients who underwent abdomen diffusion-weighted magnetic resonance imaging (DW MRI) in our clinic between April 2015 and September 2016 was analyzed. Of these patients, 42 had benign bowel wall thickening and 39 had malignant bowel wall thickening. The values of ADC were measured with two different b-values (400, 1000 s/mm2). Benign and malignant ADC values were compared using areas under the receiver-operating characteristic (ROC) curve. Results: According to the ADC values, the mean ADC values (x10-3 mm2/s) of benign lesions were 1.42±0.17 for b 400, 1.39±0.12 for b 1000. The mean ADC values (x10-3 mm2/s) of malignant lesions were 1.08±0.15 for b 400, 1.02±0.13 for b 1000. There were significantly lower ADC values in malignant lesions in all b values (P=.001 for b 400, P=.001 for b 1000). ROC analysis showed that a cut-off value of 1.24 x 10-3 mm2/s between the malignant and benign values with a sensitivity of 91 %, specificity of 85 %, and an accuracy of 84 %. The positive predictive value, negative predictive value, and diagnostic accuracy of ADC values were determined to be 97 %, 86 %, and 88 % respectively. Conclusion: Measurement of ADC values by DWI was effective in differentiation of malignant diffuse scirrhous types of bowel wall thickening from benign bowel wall thickening.

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“…MRI utilizing diffusion-weighted imaging (DWI) has also emerged as a possible tool for discriminating between malignant and non-malignant lymph nodes. Cho et al reported a sensitivity of 78% and specificity of 67% using this in staging of colorectal cancer [45].…”

Section: Discussionmentioning

confidence: 98%

Pre-Operative Perihepatic Lymph Node Assessment in Colorectal Cancer Liver Metastasis—A Review of Current Literature

Yong¹,

Burrows²,

Christophi³

2017

OJMI

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Objective: Perihepatic lymph node involvement in colorectal cancer liver metastases is a negative prognostic factor. Resection of certain nodal stations around the liver has been shown to possibly improve survival. The aim of this review is to interrogate current literature on pre-operative investigations in diagnosing lymph node involvement. Method: A systematic review was conducted of articles published since 2006 to determine usefulness of pre-operative imaging in diagnosing lymph node involvement in colorectal cancer liver metastases. Results: Only 2 papers met the inclusion criteria for this study. Computed tomography (CT) scans were found to have sensitivities of 33% and 40%, specificities of 94% and 92%, positive predictive values (PPV) of 56% and 30%, and negative predictive values (NPV) of 85% and 95%. Positron emission tomography (PET) was studied in one of the paper and was found to have sensitivity, specificity, PPV and NPV of 57%, 100%, 100%, and 88% respectively. Conclusion: There is a significant lack of research on pre-operative investigations of perihepatic lymph node involvement in colorectal cancer liver metastases. Pre-operative CT and PET scans in assessing perihepatic lymph nodes were shown to be inaccurate. Newer pre-operative imaging modalities and research would be needed.

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Apparent diffusion coefficient for discriminating metastatic from non-metastatic lymph nodes in primary rectal cancer

Cited by 86 publications

References 29 publications

Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma

Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma

The utility of diffusion-weighted magnetic resonance imaging in differentiation of benign and malignant diffuse colon wall thickening

Pre-Operative Perihepatic Lymph Node Assessment in Colorectal Cancer Liver Metastasis—A Review of Current Literature

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