Apparent Diffusion Coefficient Histograms of Human Papillomavirus–Positive and Human Papillomavirus–Negative Head and Neck Squamous Cell Carcinoma: Assessment of Tumor Heterogeneity and Comparison with Histopathology

Perrot, Thomas de; Lenoir, Vincent; Ayllón, M. Domingo; Dulguerov, Nicolas; Pusztaszeri, Marc; Becker, Minerva

doi:10.3174/ajnr.a5370

Cited by 64 publications

(90 citation statements)

References 27 publications

(51 reference statements)

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“…HPV-negative tumors were correlated with high ADC-values (r = 0.452). This is in line with some previous studies [28,[33][34][35], in which higher ADC histogram parameters in HPV-negative patients were found. This was confirmed by Meyer et al [36], who found a negative correlation of high ADC max and ADC SD with low P53 expression in HPVnegative tumors, which lead to minimal cell cycle arrest, senescence or apoptosis [37].…”

Section: Tablesupporting

confidence: 93%

“…This was confirmed by Meyer et al [36], who found a negative correlation of high ADC max and ADC SD with low P53 expression in HPVnegative tumors, which lead to minimal cell cycle arrest, senescence or apoptosis [37]. This was attributed to a more keratinizing morphology with variable cellularity, cell shape, keratin pearls, large intratumoral necrosis, hemorrhage and stromal cells found in HPV-negative tumors [28,31,33]. However, 2 studies did not find any differences of ADC histogram parameters between p16 status [36] or between the more accurate HPV status [15].…”

Section: Tablementioning

confidence: 71%

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Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

Martens

Noij

Zwezerijnen

et al. 2019

European Journal of Radiology

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Background and purpose: In head and neck squamous cell carcinoma (HNSCC) (chemo)radiotherapy is increasingly used to preserve organ functionality. The purpose of this study was to identify predictive pretreatment DWI-and 18 F-FDG-PET/CT-parameters for treatment failure (TF), locoregional recurrence (LR) and death in HNSCC patients treated by (chemo)radiotherapy. Materials and methods: We retrospectively included 134 histologically proven HNSCC patients treated with (chemo)radiotherapy between 2012-2017. In 58 patients pre-treatment DWI and 18 F-FDG-PET/CT were performed, in 31 patients DWI only and in 45 patients 18 F-FDG-PET/CT only. Primary tumor (PT) and largest lymph node (LN) metastasis were quantitatively assessed for TF, LR and death. Multivariate analysis was performed for 18 F-FDG-PET/CT and DWI separately and thereafter combined. In patients with both imaging modalities, positive and negative predictive value in TF and differences in LR and death, were assessed. Results: Mean follow-up was 25.6 months (interquartile-range; 14.0-37.1 months). Predictors of treatment failure, corrected for TNM-stage and HPV-status, were SUV max-PT , ADC max-PT , total lesion glycolysis (TLG-LN), ADCp20-LN (P = 0.049, P = 0.024, P = 0.031, P = 0.047, respectively). TLG-PT was predictive for LR (P = 0.003). Metabolic active tumor volume (MATV-PT) (P = 0.003), ADC GTV-PT (P < 0.001), ADCSD (P = 0.048) were significant predictors for death. In patients with both imaging modalities SUV max-PT remained predictive for treatment failure (P = 0.049), TLG-LN for LR (P = 0.003) and ADC GTV-PT for death (P < 0.001). Higher predictive value for treatment failure was found for the combination of SUV max-PT and ADC max-PT , compared to either one separately. Conclusion: Both DWI-and 18 F-FDG-PET/CT-parameters appear to have predictive value for treatment failure, locoregional recurrence and death. Combining SUV max-PT and ADC max-PT resulted in better prediction of treatment failure compared to single parameter assessment.

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Section: Tablesupporting

confidence: 93%

Section: Tablementioning

confidence: 71%

Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

Martens

Noij

Zwezerijnen

et al. 2019

European Journal of Radiology

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“…First, the HPV status of the patients showed no significant results on prognosis, which maybe due to small number of known HPV status. As many previous studies insisted that HPV status is an important factor for prognosis [ 35 ] and could affect the SUV [ 36 ] and ADC [ 37 ] measurements, it needs to be further studied with combined PET/MRI parameters in the future. In addition, SUV threshold for metabolo-volumetric parameters (MTV and TLG) is not clearly defined yet [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of simultaneous 18F-FDG PET/MRI using a combination of metabolo-volumetric parameters and apparent diffusion coefficient in treated head and neck cancer

et al. 2018

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BackgroundThe aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI for the prediction of treatment failure in surgically resected head and neck cancer. We hypothesized that PET parameters corrected by tumor cellularity (combined PET/MRI parameters) could predict the prognosis. On regional PET, maximum standardized uptake value (SUVmax) was measured as metabolic parameters. In addition, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were checked as metabolo-volumetric parameters. Mean apparent diffusion coefficient (ADCmean) of tumor was evaluated as the MRI parameter on the ADC map. Ratios between metabolic/metabolo-volumetric parameters and ADC were calculated as combined PET/MRI parameters. PET, MRI, and combined PET/MRI parameters were compared with clinicopathologic parameters in terms of treatment failure.ResultsSeventy-two patients (mean age = 55.9 ± 14.6 year, M: F = 45: 27) who underwent simultaneous 18F-FDG PET/MRI before head and neck cancer surgery were retrospectively enrolled. Twenty-two patients (30.6%) showed tumor treatment failure after head and neck cancer surgery (mean treatment failure = 13.0 ± 7.0 months). In the univariate analysis, MTV (P = 0.044) and ratios between metabolo-volumetric parameters and ADC (MTV/ADCmean, P = 0.022; TLG/ADCmean, P = 0.044) demonstrated significance among 18F-FDG PET/MRI parameters. Lymphatic invasion (P = 0.044) and perineural invasion (P = 0.046) revealed significance among clinicopathologic parameters. In the multivariate analysis, MTV (P = 0.026), MTV/ADCmean (P = 0.011), and TLG/ADCmean (P = 0.002) with lymphatic invasion (P = 0.026, 0.026, and 0.044, respectively) showed significance.ConclusionsCombined PET/MRI parameters (PET metabolo-volumetric parameters corrected by tumor cellularity) could be effective predictors of tumor treatment failure after head and neck cancer surgery in addition to MTV and clinicopathologic parameter.Electronic supplementary materialThe online version of this article (10.1186/s13550-018-0357-9) contains supplementary material, which is available to authorized users.

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“…This postprocessing tool can be applied retrospectively to all images acquired in clinical routine. 26,27 However, lack of standardized software, evolving research, and variable numeric algorithms currently limit the use of these new promising tools in clinical routine.…”

Section: Discussionmentioning

confidence: 99%

MRI with DWI for the Detection of Posttreatment Head and Neck Squamous Cell Carcinoma: Why Morphologic MRI Criteria Matter

Ailianou¹,

Mundada²,

Perrot³

et al. 2018

AJNR Am J Neuroradiol

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Apparent Diffusion Coefficient Histograms of Human Papillomavirus–Positive and Human Papillomavirus–Negative Head and Neck Squamous Cell Carcinoma: Assessment of Tumor Heterogeneity and Comparison with Histopathology

Cited by 64 publications

References 27 publications

Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

Predictive value of quantitative diffusion-weighted imaging and 18-F-FDG-PET in head and neck squamous cell carcinoma treated by (chemo)radiotherapy

Prognostic value of simultaneous 18F-FDG PET/MRI using a combination of metabolo-volumetric parameters and apparent diffusion coefficient in treated head and neck cancer

MRI with DWI for the Detection of Posttreatment Head and Neck Squamous Cell Carcinoma: Why Morphologic MRI Criteria Matter

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