Apparent diffusion coefficient measurements in normal appearing white matter may support the differential diagnosis between multiple sclerosis lesions and other white matter hyperintensities

Zacharzewska-Gondek, A.; Pokryszko−Dragan, Anna; Gondek, T.M.; Kołtowska, Anna; Gruszka, Ewa; Budrewićz, Sławomir; Sąsiadek, Marek; Bladowska, Joanna

doi:10.1016/j.jns.2018.12.018

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…The conventional MR imaging protocol for MS patients consisted of axial T1-weighted SE, axial T2-weighted FSE, axial FLAIR, sagittal and coronal T2-weighted FRFSE, axial DWI SE/EPI sequence and post-gadolinium T1-weighted 3D-FSPGR images. DWI was performed using an axial single shot, spin-echo type echo-planar images with the following parameters: b = 0 and b = 1,000 mm 2 /s (TE 89.9 ms, TR 8,000 ms, FOV 26 cm, matrix 128 × 128), thickness: 5 mm, spacing: 0, time of acquisition: 40 s. We used the same method of image acquisition as described in our previously published paper 33 .…”

Section: Methodsmentioning

confidence: 99%

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The role of ADC values within the normal-appearing brain in the prognosis of multiple sclerosis activity during interferon-β therapy in the 3-year follow-up: a preliminary report

Zacharzewska-Gondek

Pokryszko−Dragan

Budrewićz

et al. 2020

Sci Rep

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Predictors of multiple sclerosis (MS) activity during disease-modifying treatment are being extensively investigated. The aim of this study was to assess the prognosis of NEDA (no evidence of disease activity) status during IFN-β (interferon-β) treatment, using apparent diffusion coefficient (ADC) measurements obtained at initial MRI (magnetic resonance imaging). In 87 MS patients treated with IFN-β, ADC values were calculated for 13 regions of normal-appearing white and grey matter (NAWM, NAGM) based on MRI performed with a 1.5 T magnet before (MS0, n = 45) or after one year of therapy (MS1, n = 42). Associations were evaluated between ADC, conventional MRI findings, demographic and clinical factors and NEDA status within the following 3 years using logistic, Cox and multinomial logistic regression models. NEDA rates in the MS0 group were 64.4%, 46.5% and 33.3% after the 1st, 2nd and 3rd year of treatment, respectively and in MS1 patients 71.4% and 48.7% for the periods 1st–2nd and 1st–3rd years of treatment, respectively. ADC values in the NAWM regions contributed to loss of NEDA and its clinical and radiological components, with a 1–3% increase in the risk of NEDA loss (p = 0.0001–0.0489) in both groups. ADC measurements may have an additional prognostic value with regard to NEDA status.

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Section: Methodsmentioning

confidence: 99%

“…We decided to choose many regions of interest in an attempt to obtain a more comprehensive insight in a potentially diffused pathology involving NAWM and NAGM. We used the same methods in image analysis and post-processing as we presented in our previously published study 33 .…”

Section: Methodsmentioning

confidence: 99%

The role of ADC values within the normal-appearing brain in the prognosis of multiple sclerosis activity during interferon-β therapy in the 3-year follow-up: a preliminary report

Zacharzewska-Gondek

Pokryszko−Dragan

Budrewićz

et al. 2020

Sci Rep

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“…On the other hand, decreased NAA in MS lesions is a commonly reported abnormality among elevated choline (Cho) and myo-inositol (mI) ( Heckova et al, 2022 ; Lipka et al, 2023 ). However, only a few studies compared WMLs of migraine and MS patients and are mostly confined to diffusion-weighted imaging (DWI) ( Orsi et al, 2015 ; Zacharzewska-Gondek et al, 2019 ). Our recent study concluded that an accurate differential diagnosis of WMLs by conventional MRI was probably not possible in individual patients ( Kamson et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Differentiation of hemispheric white matter lesions in migraine and multiple sclerosis with similar radiological features using advanced MRI

John,

Kis-Jakab,

Komáromy

et al. 2024

Front. Neurosci.

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Background and aimWhite matter hyperintensities (WMHs), presented on T2-weighted or fluid-attenuated inversion recovery magnetic resonance imaging (MRI) sequences, are lesions in the human brain that can be observed in both migraine and multiple sclerosis (MS).MethodsSeventeen migraine patients and 15 patients with relapsing–remitting multiple sclerosis with WMHs, and 17 healthy subjects age-and sex-matched to the migraine group were prospectively enrolled and underwent conventional and advanced MRI studies with diffusion-and perfusion-weighted imaging and single voxel proton magnetic resonance spectroscopy.ResultsIn both disease groups, elevated T2 relaxation time, apparent diffusion coefficient (ADC) values, and decreased N-acetyl-aspartate levels were found in the intralesional white matter compared to the contralateral normal-appearing white matter (NAWM), while there was no difference between the hemispheres of the control subjects. Migraine patients had the lowest intralesional creatine + phosphocreatine and myo-inositol (mI) values among the three groups, while patients with MS showed the highest intralesional T1 and T2 relaxation times, ADC, and mI values. In the contralateral NAWM, the same trend with mI changes was observed in migraineurs and MS patients. No differences in perfusion variables were observed in any groups.ConclusionOur multimodal study showed that tissue damage is detectable in both diseases. Despite the differences in various advanced MRI measures, with more severe injury detected in MS lesions, we could not clearly differentiate the two white matter lesion types.

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Demyelinating Diseases

Capizzano

Moritani

Romeo

2021

Diffusion-Weighted MR Imaging of the Brain, Head and Neck, and Spine

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Apparent diffusion coefficient measurements in normal appearing white matter may support the differential diagnosis between multiple sclerosis lesions and other white matter hyperintensities

Cited by 4 publications

References 32 publications

The role of ADC values within the normal-appearing brain in the prognosis of multiple sclerosis activity during interferon-β therapy in the 3-year follow-up: a preliminary report

The role of ADC values within the normal-appearing brain in the prognosis of multiple sclerosis activity during interferon-β therapy in the 3-year follow-up: a preliminary report

Differentiation of hemispheric white matter lesions in migraine and multiple sclerosis with similar radiological features using advanced MRI

Demyelinating Diseases

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