Apparent Diffusion Coefficient Values for Discriminating Benign and Malignant Breast MRI Lesions: Effects of Lesion Type and Size

Partridge, Savannah C.; Mullins, Christiane; Kurland, Brenda F.; Allain, Michael D.; DeMartini, Wendy B.; Eby, Peter R.; Lehman, Constance D.

doi:10.2214/ajr.09.3534

Cited by 155 publications

(138 citation statements)

References 28 publications

Supporting

Mentioning

121

Contrasting

Order By: Relevance

“…A previous study by Partridge et al (32) reported that for the same b value, the diagnostic performance of ADC was lower in NME lesions compared with masses larger than 1 cm (34). Another study carried out by the same researchers also suggested that ADC measurements may be more valuable for distinction of masses than for differentiating lesions with NME (35). We also found that there was no statistical difference when considering NME internal enhancement and NME distribution in verifying malignancy.…”

Section: Discussionsupporting

confidence: 66%

MRI in the differential diagnosis of primary architectural distortion detected by mammography

Lifang¹,

Zhai²,

Liu³

et al. 2016

Diagn Interv Radiol

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 66%

MRI in the differential diagnosis of primary architectural distortion detected by mammography

Lifang¹,

Zhai²,

Liu³

et al. 2016

Diagn Interv Radiol

View full text Add to dashboard Cite

“…Breast MRI is an established supplemental technique to mammography and ultrasonography for evaluation of suspicious breast lesions. Diffusion-weighted MRI (DWI) has recently been integrated into the standard breast MRI for discrimination of benign and malignant breast lesions obtained with dynamic contrast-enhanced MRI [1][2][3][4][5][6][7][8][9][10][11][12][13]. DWI is a non-invasive technique that represents the biological character of the mainly Brownian movement of protons in bulk water molecules in vivo.…”

mentioning

confidence: 99%

Correlation of the apparent diffusion coefficiency values on diffusion-weighted imaging with prognostic factors for breast cancer

Sy¹,

Chang²,

Hj³

et al. 2012

The British Journal of Radiology

163

130

View full text Add to dashboard Cite

Objective: The aim of this study was to correlate the apparent diffusion coefficient (ADC) value of breast cancer with prognostic factors. Methods: 335 patients with invasive ductal carcinoma not otherwise specified (IDC NOS) and ductal carcinoma in situ (DCIS) who underwent breast MRI with diffusionweighted imaging were included in this study. ADC of breast cancer was calculated using two b factors (0 and 1000 s mm -2 ). Mean ADCs of IDC NOS and DCIS were compared and evaluated. Among cases of IDC NOS, mean ADCs were compared with lymph node status, size and immunochemical prognostic factors using Student's t-test. ADC was also correlated with histological grade using the Kruskal-Wallis test. Results: Mean ADC of IDC NOS was significantly lower than that of DCIS (p,0.001). However, the mean ADC of histological grade of IDC NOS was not significantly different (p50.564). Mean ADC of oestrogen receptor (ER)-positive or progesterone receptor (PR)-positive cancer was significantly lower than that of ER-negative or PRnegative cancer (p50.003 vs p50.032). Mean ADC of Ki-67 index-positive cancer was significantly lower than that of Ki-67 index-negative cancer (p50.028). Mean ADC values of cancers with increased microvascular density (MVD) were significantly lower than those of cancer with no MVD increase (p50.009). No correlations were observed between mean ADC value and human growth factor receptor 2 expression, tumour size and lymph node metastasis. Conclusion: Low ADC value was correlated with positive expression of ER, PR, increased Ki-67 index, and increased MVD of breast cancer. Breast MRI is an established supplemental technique to mammography and ultrasonography for evaluation of suspicious breast lesions. Diffusion-weighted MRI (DWI) has recently been integrated into the standard breast MRI for discrimination of benign and malignant breast lesions obtained with dynamic contrast-enhanced MRI [1][2][3][4][5][6][7][8][9][10][11][12][13]. DWI is a non-invasive technique that represents the biological character of the mainly Brownian movement of protons in bulk water molecules in vivo. Apparent diffusion coefficient (ADC) values are quantified by measurement of mean diffusivity along three orthogonal directions, which are affected by cellularity of the tissue, fluid viscosity, membrane permeability and blood flow [7,[9][10][11]. Microstructural characteristics, including water diffusion and blood microcirculations in capillary networks, were associated with ADC value. Decreased movement of molecules in highly cellular tissue showed correlation with a low ADC value [3,4]. Several studies of DWI of the breast have reported significantly lower ADC values in malignant tumours, compared with benign breast lesions and normal tissue [1-3, 5-11, 14]. Classic prognostic markers, including tumour size and grade, and lymph node status in patients with breast cancer, and molecular markers, including oestrogen receptor (ER), progesterone receptor (PR), Ki-67 index, human growth factor receptor 2 (HER2) protein and angiogenic mo...

show abstract

“…The ADC values of lesion groups and normal fibroglandular tissue derived from the literature and the ADC values we identified in our study are given in Table 3 for comparison (7,8,(17)(18)(19)(20)(21)(22)(23)(24) . As seen, although there are slight differences between the ADC values of various studies, statistically significant differences have been identified between groups in all studies.…”

Section: Resultsmentioning

confidence: 99%

“…We also observed a statistically significant difference between the groups (except the difference between normal tissue and benign lesions), thus our study is consistent with literature data. Guo et al (7) Rubesova et al (17) Woodhams et al (18) Kuroki et al (19) Hatakenaka et al (8) Sinha and Sinha (20) Marini et al (21) Luo et al (22) Patridge et al (23) Arantes Pereira et. al.…”

Section: Resultsmentioning

confidence: 99%

Role of diffusion-weighted MR Imaging in solid breast masses and complicated cysts

Canverenler¹,

Adıbelli²,

Canverenler³

et al. 2017

Terh

View full text Add to dashboard Cite

Objective: The purpose of this study is to evaluate the characteristics of malign/benign lesions and complicated cysts/abscesses in diffusion weighted magnetic resonance imaging and to investigate the contribution of apparent diffusion coefficient (ADC) to differential diagnosis. Methods: In this retrospective study; histopathologically proven 177 lesions (21 complicated cysts, 91 malign and 65 bening lesions) were evaluated in 116 women using conventional MRI and diffusion weighted imaging (DWI /sec (P<0.001), respectively. The ADC values identified for complicated cysts/abscesses are significantly lower than the ADC values of benign and malign values reported in the literature. Conclusion: As a result, the specificity, positive predictive value and negative predictive value of DWI when it is used alone are higher than conventional MRI, while sensitivity of DWI is nearly the same. DWI is effective in detecting breast lesions and also ADC value is useful in distinguishing among complicated cysts/abscesses, malignant and benign breast lesions.

show abstract

Apparent Diffusion Coefficient Values for Discriminating Benign and Malignant Breast MRI Lesions: Effects of Lesion Type and Size

Cited by 155 publications

References 28 publications

MRI in the differential diagnosis of primary architectural distortion detected by mammography

MRI in the differential diagnosis of primary architectural distortion detected by mammography

Correlation of the apparent diffusion coefficiency values on diffusion-weighted imaging with prognostic factors for breast cancer

Role of diffusion-weighted MR Imaging in solid breast masses and complicated cysts

Contact Info

Product

Resources

About