Apparent Role of Hydroxyl Radicals in Oxidative Brain Injury Induced by Sodium Nitroprusside

Rauhala, Pekka; Khaldi, Ahmad; Mohanakumar, Kochupurackal P.; Chiueh, Chuang C.

doi:10.1016/s0891-5849(97)00386-9

Cited by 96 publications

(75 citation statements)

References 35 publications

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“…Rauhala et al 21 also showed that SNP generated OH • − by the Fenton reaction in vitro in the presence of ascorbate. We have also reported that intrastriatal microinjection of SNP (50 nmol) caused neuronal cell death; however, neither NOC-18 (50 nmol), another type of NO donor, nor sodium cyanide (50 nmol) caused cell death.…”

Section: In Vitromentioning

confidence: 98%

In VivoImaging of Reactive Oxygen Species in Mouse Brain by using [³H]Hydromethidine as a Potential Radical Trapping Radiotracer

Abe

Takai

Fukumoto

et al. 2014

J Cereb Blood Flow Metab

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To assess reactive oxygen species (ROS) production by detecting the fluorescent oxidation product, hydroethidine has been used extensively. The present study was undertaken to evaluate the potential of the hydroethidine derivative as a radiotracer to measure in vivo brain ROS production. 3 H]Hydromethidine freely penetrated into the brain where it was rapidly converted to oxidized forms, which were trapped there in response to the production of ROS. Thus, [3 H]Hydromethidine should be useful as a radical trapping radiotracer in the brain.

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Section: In Vitromentioning

confidence: 98%

In VivoImaging of Reactive Oxygen Species in Mouse Brain by using [³H]Hydromethidine as a Potential Radical Trapping Radiotracer

Abe

Takai

Fukumoto

et al. 2014

J Cereb Blood Flow Metab

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“…In fact, sodium nitroprusside (SNP) is a pro-oxidant agent that impairs cellular viability and induces lipid peroxidation in brain tissue (Rauhala et al, 1998 (Beal, 1996). NO…”

Section: +mentioning

confidence: 99%

Antioxidant properties ofTaraxacum officinalefruit extract are involved in the protective effect against cellular death induced by sodium nitroprusside in brain of rats

Colle

Arantes

Rauber

et al. 2012

Pharmaceutical Biology

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“…8 showed that luteolin reduced the DPPH free radical more potently than well-known antioxidants, glutathione and ascorbic acid, in lower concentrations (1 -3 g/ml). It has been reported that SNP could cause oxidative stress by inducing hydroxyl radical generation via the Fenton reaction (34). Furthermore, flavonoids are believed to be antioxidants or free radical scavengers in the biological system.…”

Section: +mentioning

confidence: 99%

Protective Effect of Luteolin on an Oxidative-Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice

et al. 2013

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Abstract. Accumulating lines of evidence showed that luteolin, a polyphenolic compound, has potent neuroprotective effects. The purpose of this study was to examine whether luteolin can protect against sodium nitroprusside (SNP)-induced oxidative damage in mouse brain. Intrastriatal co-injection of luteolin (3 -30 nmol) with SNP (10 nmol) dose-dependently protected against brain damage and motor dysfunction. Oral administrations of luteolin (600 -1200 mg/kg) dosedependently protected against brain damage and motor dysfunction induced by striatal injection of SNP. Furthermore, luteolin (30 -100 M) concentration dependently protected against Fe 2+ -induced lipid peroxidation in mouse brain homogenate. Luteolin (1 -100 g/ml) showed potent DPPH radical scavenging ability, when compared with ascorbic acid and glutathione. Finally, a ferrozine assay showed that luteolin (30 -100 g/ml) has Fe 2+ -chelating ability, but this was weaker than that of ethylenediaminetetraacetic acid. These results suggest that intrastriatal or oral administration of luteolin protected mice brain from SNP-induced oxidative damage by scavenging and chelating effects.

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Apparent Role of Hydroxyl Radicals in Oxidative Brain Injury Induced by Sodium Nitroprusside

Cited by 96 publications

References 35 publications

In VivoImaging of Reactive Oxygen Species in Mouse Brain by using [³H]Hydromethidine as a Potential Radical Trapping Radiotracer

In VivoImaging of Reactive Oxygen Species in Mouse Brain by using [³H]Hydromethidine as a Potential Radical Trapping Radiotracer

Antioxidant properties ofTaraxacum officinalefruit extract are involved in the protective effect against cellular death induced by sodium nitroprusside in brain of rats

Protective Effect of Luteolin on an Oxidative-Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice

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Apparent Role of Hydroxyl Radicals in Oxidative Brain Injury Induced by Sodium Nitroprusside

Cited by 96 publications

References 35 publications

In VivoImaging of Reactive Oxygen Species in Mouse Brain by using [3H]Hydromethidine as a Potential Radical Trapping Radiotracer

In VivoImaging of Reactive Oxygen Species in Mouse Brain by using [3H]Hydromethidine as a Potential Radical Trapping Radiotracer

Antioxidant properties ofTaraxacum officinalefruit extract are involved in the protective effect against cellular death induced by sodium nitroprusside in brain of rats

Protective Effect of Luteolin on an Oxidative-Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice

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In VivoImaging of Reactive Oxygen Species in Mouse Brain by using [³H]Hydromethidine as a Potential Radical Trapping Radiotracer

In VivoImaging of Reactive Oxygen Species in Mouse Brain by using [³H]Hydromethidine as a Potential Radical Trapping Radiotracer