Apparent thermodynamic models for determination of the solubility of N-acetyl-1,3-phenylenediamine in eight pure solvents and two different miscible systems at T= (278.15–323.15) K

Zhang, Xinxin; Yang, Wenge; Zhao, Wangdan; Li, Hongjie; Fan, Shimin; Hao, Jianfeng; Jian, Zhang; Sheng, Huace

doi:10.1016/j.molliq.2017.08.030

Cited by 10 publications

(11 citation statements)

References 17 publications

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“…This is a very authoritative mathematical description of the binary solid–liquid phase equilibrium and has been widely used to correlate the solubility of solutes in solvents. The modified Apelblat equation shows the trend of temperature solubility of l -tryptophan in a single solvent or in binary solvents. , The concrete equation can be described as eq where x is the molar fraction solubility of l -tryptophan in an organic solvent, and T is the absolute temperature. A , B , or C is an empirical constant obtained by nonlinear multiple regression analysis, in which parameters A and B , respectively, indicate the effect of solution nonideality on the solubility of solute and the change of the solute activity coefficient, and parameter C reveals the effect of temperature on enthalpy, all of which are listed in Table .…”

Section: Resultsmentioning

confidence: 99%

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Saturated Solubility and Thermodynamic Evaluation of l-Tryptophan in Eight Pure Solvents and Three Groups of Binary Mixed Solvents by the Gravimetric Method at T = 278.15–333.15 K

et al. 2019

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In this research, solubility of l-tryptophan in water, methanol, ethanol, acetone, isopropanol, n-butanol, acetonitrile, ethyl acetate, organic pure solvent, and in three binary mixed solvents (water + acetonitrile), (water + methanol), and (water + isopropanol) at the temperature range of T = 278.15–333.15 K was determined with the gravimetric method. The experimental results show that the solubility of l-tryptophan in the above solvents increased as temperature rose, and it achieved the highest dissolution efficiency in water. The improved Apelblat model, the Buchowski–Ksiazaczak λh model, the Redlich–Kister (CNIBS/R–K) model, and the Jouyban–Acree model were used to nonlinearly fit the experimental data of solubility, and the consistency was good. The physicochemical information of l-tryptophan provided in this report may be helpful for its extraction/separation, recrystallization, purification, and formulation development.

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Section: Resultsmentioning

confidence: 99%

“…The modified Apelblat equation shows the trend of temperature solubility of L-tryptophan in a single solvent or in binary solvents. 15,16 The concrete equation can be described as eq 4…”

Section: Modified Apelblat Equationmentioning

confidence: 99%

Saturated Solubility and Thermodynamic Evaluation of l-Tryptophan in Eight Pure Solvents and Three Groups of Binary Mixed Solvents by the Gravimetric Method at T = 278.15–333.15 K

et al. 2019

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“…This model was first proposed by Apelblat (Figures and ) . The modified Apelblat equation can more accurately describe the effect of temperature on the solubility of 2-amino-5-chloro-3-methylbenzoic acid . This model is represented as eq 4. In this model, x represents the mole fraction solubility of 2-amino-5-chloro-3-methylbenzoic acid, and T is the experimental temperature (Tables and ).…”

Section: Resultsmentioning

confidence: 99%

“…15 The modified Apelblat equation can more accurately describe the effect of temperature on the solubility of 2-amino-5-chloro-3-methylbenzoic acid. 16 This model is represented as eq 4.…”

Section: Resultsmentioning

confidence: 99%

Solubility of 2-Amino-5-chloro-3-methylbenzoic Acid in Ten Pure Solvents and Three Groups of Binary Mixed Solvents at T = 278.15–323.15 K

Cui

Wang

et al. 2021

J. Chem. Eng. Data

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In this paper, the solubility of 2-amino-5-chloro-3-methylbenzoic acid under 0.1 MPa atmospheric pressure and temperature T = 278.15−323.15 K was determined by gravimetric analysis. Considering the safety and the cost of solvents, we selected the following 10 pure solvents and three binary mixed solvents: methanol, ethanol, n-butanol, acetone, acetonitrile, ethyl acetate, n-propanol, isopropanol, xylene, and n-hexane (n-hexane + acetone), (acetonitrile + acetone), and (methanol + acetone). The aim is to find suitable solvent systems for the recrystallization of 2amino-5-chloro-3-methylbenzoic acid. The results indicate that the solubility of 2amino-5-chloro-3-methylbenzoic acid is positively correlated with temperature, and the solubility of 2-amino-5-chloro-3-methylbenzoic acid is better in acetone. The modified Apelblat model, the Buchowski−Ksiazaczak λh model, the Redlich−Kister (CNIBS/R−K) model, and the Jouyban−Acree model were used to fit the solubility data of 2-amino-5-chloro-3-methylbenzoic acid in different solvents, and the experimental values were in good agreement with the calculated values. By comparing the four models, the modified Apelblat model was found to have a good correlation in pure solvents, and the Redlich−Kister (CNIBS/R−K) model was more suitable than the other two models in binary mixed solvents.

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“…The method for solubility measurement is a static equilibrium method according to the literature. − Excess 3-methyl-6-nitroindazole was added to 10 mL sealed tubes prefilled with 6 mL solvent. The tubes were placed in a glass container which was connected to thermostatic bath at the temperature 278.15 to 328.15 K and stirred on the magnetic stirrer.…”

Section: Methodsmentioning

confidence: 99%

Solubility Measurement, Correlation, and Molecular Interactions of 3-Methyl-6-nitroindazole in Different Neat Solvents and Mixed Solvents from T = 278.15 to 328.15 K

et al. 2019

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Solubility and thermodynamic data of 3-methyl-6-nitroindazole in eight pure solvents and three mixed solvents were obtained experimentally via the static equilibrium method within the temperature range of (278.15−328.15) K under atmospheric pressure. Whether in a pure solvent system or a mixed system, the results show that mole fraction solubilities of 3-methyl-6-nitroindazole increased with increasing temperature. The maximum mole fraction solubilities of 3-methyl-6-nitroindazole were recorded in neat N,N-dimethylformamide and the minimum in water. The molecular interactions of 3-methyl-6-nitroindazole with solvents were determined by the determination of activity coefficients of 3-methyl-6-nitroindazole. Among the three groups of mixed solvents measured, the molar fraction of 3-methyl-6-nitroindazole in (DMF + water) system is the maximum. The experimental solubility values of 3-methyl-6-nitroindazole were fitted well with five versatile models with an R 2 value of >0.99.

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Apparent thermodynamic models for determination of the solubility of N-acetyl-1,3-phenylenediamine in eight pure solvents and two different miscible systems at T= (278.15–323.15) K

Cited by 10 publications

References 17 publications

Saturated Solubility and Thermodynamic Evaluation of l-Tryptophan in Eight Pure Solvents and Three Groups of Binary Mixed Solvents by the Gravimetric Method at T = 278.15–333.15 K

Saturated Solubility and Thermodynamic Evaluation of l-Tryptophan in Eight Pure Solvents and Three Groups of Binary Mixed Solvents by the Gravimetric Method at T = 278.15–333.15 K

Solubility of 2-Amino-5-chloro-3-methylbenzoic Acid in Ten Pure Solvents and Three Groups of Binary Mixed Solvents at T = 278.15–323.15 K

Solubility Measurement, Correlation, and Molecular Interactions of 3-Methyl-6-nitroindazole in Different Neat Solvents and Mixed Solvents from T = 278.15 to 328.15 K

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