Apparent transverse relaxation () on <scp>MRI</scp> as a method to differentiate treatment effect (pseudoprogression) versus progressive disease in chemoradiation for malignant glioma

Belliveau, Jean-Guy; Macdonald, David R.; MacDonald, Maria; Klassen, L. Martyn; Menon, Ravi S.

doi:10.1111/1754-9485.12694

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…65 Progression pathology relates to increased perfusion and increased content of deoxyhemoglobin in the tumor bed, and thus may be detected using susceptibility-weighted sequences. Belliveau et al 66 established that true glioma progression is accompanied by a higher ratio of R2* between enhancing and non-enhancing lesions (>1.3) than are pseudoprogression cases, which show a ratio of 1. As MRF provides quantitative multiparameteric maps in a single fast acquisition, this technique should be able to simplify and shorten clinical protocols, thereby improving patient comfort and throughput while yielding valuable MRI-based biomarkers.…”

Section: T2 and T2* Mr Relaxometry In Glioma Treatment Response Asses...mentioning

confidence: 99%

Magnetic resonance relaxometry in quantitative imaging of brain gliomas: A literature review

et al. 2023

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Magnetic resonance (MR) relaxometry is a quantitative imaging method that measures tissue relaxation properties. This review discusses the state of the art of clinical proton MR relaxometry for glial brain tumors. Current MR relaxometry technology also includes MR fingerprinting and synthetic MRI, which solve the inefficiencies and challenges of earlier techniques. Despite mixed results regarding its capability for brain tumor differential diagnosis, there is growing evidence that MR relaxometry can differentiate between gliomas and metastases and between glioma grades. Studies of the peritumoral zones have demonstrated their heterogeneity and possible directions of tumor infiltration. In addition, relaxometry offers T2* mapping that can define areas of tissue hypoxia not discriminated by perfusion assessment. Studies of tumor therapy response have demonstrated an association between survival and progression terms and dynamics of native and contrast-enhanced tumor relaxometric profiles. In conclusion, MR relaxometry is a promising technique for glial tumor diagnosis, particularly in association with neuropathological studies and other imaging techniques.

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Section: T2 and T2* Mr Relaxometry In Glioma Treatment Response Asses...mentioning

confidence: 99%

Magnetic resonance relaxometry in quantitative imaging of brain gliomas: A literature review

et al. 2023

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“…coefficient is also sensitive to hemorrhage and calcifications, and it can be measured within a specific region of interest by fitting signal decay through multiechoes gradient echo sequences. A pilot study in glioblastoma patients showed that this coefficient, also referred as apparent transverse relaxation, shows lower value in pseudoprogressing compared with progressing contrast –enhancing lesions [88]. Preclinical data suggest that R2* coefficient might even predict radionecrosis 10 weeks before morphological changes [89].…”

Section: Current Mri Imaging In Posttreatment Tumor Evaluationmentioning

confidence: 99%

Current emerging MRI tools for radionecrosis and pseudoprogression diagnosis

Nichelli

Casagranda

2021

Current Opinion in Oncology

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Purpose of review This review aims to cover current MRI techniques for assessing treatment response in brain tumors, with a focus on radio-induced lesions. Recent findings Pseudoprogression and radionecrosis are common radiological entities after brain tumor irradiation and are difficult to distinguish from real progression, with major consequences on daily patient care. To date, shortcomings of conventional MRI have been largely recognized but morphological sequences are still used in official response assessment criteria. Several complementary advanced techniques have been proposed but none of them have been validated, hampering their clinical use. Among advanced MRI, brain perfusion measures increase diagnostic accuracy, especially when added with spectroscopy and susceptibility-weighted imaging. However, lack of reproducibility, because of several hard-to-control variables, is still a major limitation for their standardization in routine protocols. Amide Proton Transfer is an emerging molecular imaging technique that promises to offer new metrics by indirectly quantifying intracellular mobile proteins and peptide concentration. Preliminary studies suggest that this noncontrast sequence may add key biomarkers in tumor evaluation, especially in posttherapeutic settings. Summary Benefits and pitfalls of conventional and advanced imaging on posttreatment assessment are discussed and the potential added value of APT in this clinicoradiological evolving scenario is introduced.

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“…As many patients suffering from BM either receive stereotactic or whole-brain radiotherapy, it is crucial during tumor monitoring to differentiate between "pseudoprogression" following successful treatment and true recurrence of the disease (58,59). Although not applied to brain metastases so far, R2 *mapping, another susceptibility-related imaging approach (60) has recently been introduced as a promising imaging marker to differentiate pseudoprogression from progressive disease in glioblastoma multiforme (61). The authors reported a rim of high R2 * values with an accompanied SWI-hypointensity as indicative of pseudoprogression as well as a ratio of R2 * in the contrast-enhancing to the non-contrast enhancing lesion close to 1.…”

Section: Swi In the Assessment Of Treatment Responsesmentioning

confidence: 99%

Clinical Value of Susceptibility Weighted Imaging of Brain Metastases

2020

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MRI is used for screening, initial diagnosis and follow-up of brain metastases. Multiparametric MRI protocols encompass an array of image sequences to depict key aspects of metastases morphology and biology. Given the recent safety concerns of Gd-administration and the retention of linear Gd-agents in the brain, non-contrast sequences are currently evaluated regarding their diagnostic value for brain imaging studies. Susceptibility weighted imaging has been established as a valuable clinical and research tool that is heavily used in clinical practice and utilized in diverse pathologies ranging from neuroinflammation, neurovascular disease to neurooncology. We review the value of SWI in the field of brain metastases with an emphasis on its role in early diagnosis, determination of the primary tumor entity, treatment monitoring and discuss therapy-associated changes that can affect SWI. We also review recent insights on the role of "isolated SWI signals" and the controversy on the specificity of SWI for the early detection of brain metastases.

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Apparent transverse relaxation () on MRI as a method to differentiate treatment effect (pseudoprogression) versus progressive disease in chemoradiation for malignant glioma

Abstract: Our method seems promising for the accurate identification of psPD, and the technique is amenable to evaluation in larger, multi-centre patient cohorts.

Cited by 5 publications

References 29 publications

Magnetic resonance relaxometry in quantitative imaging of brain gliomas: A literature review

Magnetic resonance relaxometry in quantitative imaging of brain gliomas: A literature review

Current emerging MRI tools for radionecrosis and pseudoprogression diagnosis

Clinical Value of Susceptibility Weighted Imaging of Brain Metastases

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