Appendiceal Gastrointestinal Stromal Tumor

Yap, Wai Ming; Tan, Hui Zhuan; Goh, Seng Geok Nicholas; Chuah, Khoon Leong

doi:10.1097/01.pas.0000180445.79398.d4

Cited by 20 publications

(19 citation statements)

References 6 publications

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“…The tumor size varied from 2.5 to 60 mm (median: 12 mm), and our case represents the largest appendiceal GIST reported to date. The finding of low mitotic count in this case is consistent with the findings reported by others (3)(4)(5)(6). In summary, we document the extremely rare occurrence of appendiceal GIST, increasing the total number of reported cases to nine.…”

supporting

confidence: 83%

“…However, it can also arise as a secondary effect of drugs containing mainly mesalamine (4,5), which was thought to be a beneficial medication in the treatment of patients with IBD. We herein report a 29-year-old woman with Crohn's disease (CD) who developed acute myocarditis while receiving per os mesalamine (5-aminosalicylic acid [ASA]).…”

Section: Department Of Surgery Soonchunhyang University Bucheon Hospmentioning

confidence: 99%

“…Appendiceal GISTs are extremely rare, with only eight cases reported to date (3)(4)(5)(6). Based on the previously reported eight cases and our one case, the patients with appendiceal GISTs included six (67%) males and three (33%) females, with a median age of 66 years (range: 56-78 years).…”

mentioning

confidence: 99%

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Gastrointestinal stromal tumor of the appendix

Chung¹,

Song²

2012

Turk J Gastroenterol

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A 67-year-old male presenting with right lower quadrant abdominal pain was referred to our hospital. On physical examination, an approximately 10 cm mass was palpated in the right lower quadrant area with mild tenderness. A computed tomography of his abdomen revealed a well-demarcated and enhanced tumor in the appendix, measuring approximately 5.6x5.0x8.0 cm. At laparotomy, a solid appendiceal mass was removed by right hemicolectomy. The cut section of the appendix showed that the tumor was a 6.0x4.0x3.0 cm polypoid lesion with hemorrhage from the midportion of the appendix (Figure 1). Histological examination revealed that the tumor was composed of spindle cells with a mitotic count of <5 mitoses/50 high power fields. Immunohistochemical study revealed positive staining for CD117 (Figure 2). Based on the above findings, the tumor was diagnosed as a gastrointestinal stromal tumor (GIST) with intermediate-grade malignancy originating from the appendix. The patient had an uneventful postoperative course, and there was no evidence of recurrence in the six months after his surgery.Gastrointestinal stromal tumors can occur anywhere throughout the GI tract, but are most commonly found in the stomach or small intestine (1-3). Appendiceal GISTs are extremely rare, with only eight cases reported to date (3-6). Based on the previously reported eight cases and our one case, the patients with appendiceal GISTs included six (67%) males and three (33%) females, with a median age of 66 years (range: 56-78 years). Among the five patients who had clinical symptoms, four patients had appendicitis-like symptoms in the absence of histologic evidence of acute appendicitis, suggesting that the symptoms were caused by the tumor. The asymptomatic tumors were detected incidentally during surgery for other diseases or at autopsy. Five patients were affected by other malignant tumors. The presenting malignancies included pulmonary adenocarcinoma, malignant gastric GIST, endometrial carcinoma, urinary bladder carcinoma, and mantle cell lymphoma. One patient had neurofibromatosis type 2. The tumors were located in the proximal (n=1, 11%), mid (n=6, 67%) and tip (n=2, 22%) por- Gastrointestinal stromal tumor of the appendix Apendiksin gastrointestinal stromal tümörü Manuscript

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confidence: 83%

Section: Department Of Surgery Soonchunhyang University Bucheon Hospmentioning

confidence: 99%

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Gastrointestinal stromal tumor of the appendix

Chung¹,

Song²

2012

Turk J Gastroenterol

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“…Appendiceal GISTs are extremely rare making up approximately 0.1% of all cases [7], with less than ten cases reported in the literature thus far, all of which were benign and measuring less that 3 cm in diameter. Reported presentations include appendicitis-like symptoms, incidental finding during unrelated work-up [8,9], and spontaneous hemorrhage [10].…”

Section: Discussionmentioning

confidence: 99%

Malignant Appendiceal GIST: Case Report and Review of the Literature

Elazary

Schlager

Khalaileh

et al. 2009

J Gastrointest Canc

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“…GISTs of the vermiform appendix constitute only 0.1% of all GISTs (1), with only 16 cases reported in the English literature to date (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). The characteristics of these 17 GIST cases (including the present case) are listed in Table I.…”

Section: Discussionmentioning

confidence: 99%

Giant gastrointestinal stromal tumor of the vermiform appendix: A case report

Kaneko

Kawai

Murono

et al. 2017

Molecular and Clinical Oncology

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Abstract.Gastrointestinal stromal tumors (GISTs) of the vermiform appendix are rare, measuring <3 cm in 82.4% of the reported cases. Neoadjuvant therapy with the receptor tyrosine kinase inhibitor imatinib mesylate has the potential to improve resectability and organ preservation rates in locally advanced or metastatic/recurrent GISTs. We herein report the case of a 67-year-old male patient with an unusually large GIST (22 cm in diameter) of uncertain origin in the right lower abdominal quadrant, with a solitary peritoneal metastasis. Due to the size of this GIST and presence of metastatic disease, neoadjuvant therapy with imatinib (400 mg/day orally) was administered. Follow-up imaging studies revealed marked shrinkage of the primary and metastatic tumors. Subsequently, laparoscopic exploration revealed that the main tumor originated from the tip of the vermiform appendix, and that the peritoneal metastasis was located in the ascending mesocolon. The patient underwent laparoscopic appendectomy and excision of the peritoneal metastasis, without tumor rupture. Therefore, in appropriately selected patients, neoadjuvant imatinib for borderline resectable or oligometastatic GISTs may be a reasonable choice.

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Appendiceal Gastrointestinal Stromal Tumor

Cited by 20 publications

References 6 publications

Gastrointestinal stromal tumor of the appendix

Gastrointestinal stromal tumor of the appendix

Malignant Appendiceal GIST: Case Report and Review of the Literature

Giant gastrointestinal stromal tumor of the vermiform appendix: A case report

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