Applicability of Bipolar Charge Analyzer (BOLAR) in Characterizing the Bipolar Electrostatic Charge Profile of Commercial Metered Dose Inhalers (MDIs)

Leung, Sharon Shui Yee; Chiow, Adam Chong Ming; Ukkonen, Ari; Chan, Hak‐Kim

doi:10.1007/s11095-015-1786-z

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…Thus, the data can be verified by ensuring the total charge measured by the bipolar detectors is same as the reference value. Leung et.al 59 and Wong et.al 60 have successfully used the BOLAR™ system to characterize the charging properties of aerosol. A limitation of the BOLAR™ system is that the validity of collected data depends on how effectively the flow has been split upon entering the entering the detector tubes and the reference chamber.…”

Section: Electrostatic Charge Measurement Techniquesmentioning

confidence: 99%

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Naik

Mukherjee

Chaudhuri

2016

International Journal of Pharmaceutics

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Section: Electrostatic Charge Measurement Techniquesmentioning

confidence: 99%

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Naik

Mukherjee

Chaudhuri

2016

International Journal of Pharmaceutics

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“…10,11 Polypropylene and polycarbonate are the most commonly used materials for making plastic spacers or valved holding chambers; however, their non-conducting nature encourages electrostatic charges within the device. [12][13][14] Because drugs released from pMDIs also are electrically charged, electrostatic reactions inevitably occur between the charged walls of the accessory device and the emitted drug. Mutual repulsion between the charged entities pushes the drug particles toward the wall of the accessory device, [11][12][13][14] thus decreasing the emitted dose.…”

Section: Introductionmentioning

confidence: 99%

“…[12][13][14] Because drugs released from pMDIs also are electrically charged, electrostatic reactions inevitably occur between the charged walls of the accessory device and the emitted drug. Mutual repulsion between the charged entities pushes the drug particles toward the wall of the accessory device, [11][12][13][14] thus decreasing the emitted dose. [15][16][17] According to the Global Initiative for Asthma guidelines, 18 there are 2 efficient methods for neutralizing charges on the walls of accessory devices.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Disposable and Traditional Accessory Devices for Use With a Pressurized Metered-Dose Inhaler

et al. 2019

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BACKGROUND: The use of accessory devices with pressurized metered-dose inhalers (pMDIs) enhances aerosol delivery and helps overcome any lack of patient coordination when using the pMDI. The use of accessory devices could be influenced by the efficacy, availability, and cost of these devices. The aim of this study was to compare drug delivery with the pMDI alone and with non-antistatic and antistatic accessory devices. METHODS: The total emitted dose and aerodynamic characterization of salbutamol particles were measured for the pMDI alone and for the pMDI combined with 4 different accessory devices: a homemade spacer, the Dolphin spacer, the DispozABLE paper spacer, and the AeroChamber Plus valved holding chamber. Aerodynamic characterization was analyzed with an Andersen cascade impactor at an inhalation flow of 28.3 L/min, and drug deposition was measured with high-performance liquid chromatography. RESULTS: The mean ؎ SD total emitted dose from the pMDI alone, 155.2 ؎ 20.5 g, was the greatest of all modalities, and the difference was significant (P < .001). The homemade and Dolphin spacers had the highest mean ؎ SD deposited amounts of salbutamol remaining on their walls (ie, 124.1 ؎ 11.1 g and 131.5 ؎ 11.8 g, respectively). The mean ؎ SD total emitted doses with the AeroChamber Plus valved holding chamber (61.9 ؎ 8.9 g) and the DispozABLE paper spacer (76.4 ؎ 8.6 g) were significantly higher than the emitted doses with the other devices. The mean ؎ SD fine-particle doses emitted with the AeroChamber plus valved holding chamber (51.4 ؎ 4.7 g) and the DispozABLE paper spacer (39.7 ؎ 5.6 g) were significantly higher than those with the other devices. The AeroChamber Plus valved holding chamber had the lowest mass median aerodynamic diameter (MMAD) values, but there were no statistically significant differences in MMAD between any of the combinations of pMDI and accessory device. CONCLUSIONS: The valved holding chamber and the paper spacer had better aerodynamic characteristics than the other devices tested. We consider the antistatic devices to be the optimum devices for aerosol delivery due to their high efficacy compared to non-antistatic devices.

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“…However, issues with particle detection and analysis system through the sensing volume may occur due to the electric field caused by inhomogeneous geometry (Epping and Kuettner 2002). Another novel instrument used by Yli-Ojanpera et al 2014, Wong et al (2015) and Leung et al (2016) is Bipolar Charge Analyser (BOLAR TM ). It consist of a flow divider that distributes the flow evenly to five bipolar detectors based on the particle size range for charge measurement.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a new dispersion technique for assessing triboelectric charging of powders

Zafar

Alfano

Ghadiri

2018

International Journal of Pharmaceutics

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In a number of applications, especially in pharmaceutical drug development, there is often a very small powder quantity available for evaluating the manufacturability of new drugs. However, it is highly desirable to be able to quickly evaluate processing issues, and where possible using the smallest powder quantity. In the present work, a proprietary commercial powder dispersion device (the disperser of Malvern© Morphologi G3) is adapted to evaluate the triboelectric charging tendency. A very small powder quantity (as small as 0.1 mg) is dispersed by a pressure pulse of compressed gas such as air or nitrogen. This causes the particles to become air borne and collide with the containing walls, resulting in dispersion and leading to triboelectric charge transfer between the particles and the walls. In this work, the charging propensity of a number of materials is evaluated and the effect of particle surface functional groups on the tribo-electric charge transfer is analysed. Model materials with a well-defined shape (glass ballotini) but with different silane groups deposited on their surfaces as well as a number of organic crystalline particles (such as aspirin, α-lactose monohydrate and paracetamol) are tested. Following dispersion the particles move immediately to a Faraday cup placed directly underneath the disperser. Therefore, particle charge is measured with no decay. The method can differentiate charging of different polymorphs of the same material, different silane groups on the surfaces of glass ballotini and different crystal morphologies obtained from crystallisation from various solvents.

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Applicability of Bipolar Charge Analyzer (BOLAR) in Characterizing the Bipolar Electrostatic Charge Profile of Commercial Metered Dose Inhalers (MDIs)

Abstract: Positively and negatively charged MDI particles of different size fractions and their corresponding charge-to-mass profiles were successfully characterized by the BOLAR.

Cited by 10 publications

References 24 publications

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Evaluation of Disposable and Traditional Accessory Devices for Use With a Pressurized Metered-Dose Inhaler

Evaluation of a new dispersion technique for assessing triboelectric charging of powders

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