Applicability of Gum Karaya in the Preparation and <I>in Vitro</I> Evaluation of Losartan Potassium as Chronotherapeutic Drug Delivery System

Abstract

The objective of this investigation is to study the applicability of gum karaya, the natural gum for the preparation and in vitro evaluation of losartan potassium, as Chronotherapeutic Drug Delivery System (ChDDS). The compression-coated timed-release tablets (CCT) containing losartan potassium in the core tablet were prepared by dry coating technique with different ratios of gum karaya as the outer coat. The parameters investigated were tensile strength, friability, in vitro dissolution studies and drug concentration. The optimized formulation was further characterized by powder XRD and FTIR to investigate interactions and no interactions observed. The tensile strength and friability of all the CCT were between 1.06-1.23 MN/m 2 and < 0.3% respectively. All the CCT showed a clear lag time before a burst release of drug. However, the lag time of drug release increased as the amount of gum karaya in the outer layer increased. For instance, the lag time of LGK1, LGK2, LGK3, LGK4, LGK5, LGK6 and LGK7 were 16, 10.5, 5.5, 3, 2, 1.5 and 0.5 hrs respectively. The drug content of all the CCT was >98%. Formulation LGK3 was taken as an optimized formulation which can be exploited to achieve ChDDS of losartan potassium for the treatment of hypertension.

Development and characterization of chronotherapeutic tablets of sacubitril-valsartan supramolecular complex using hupu gum and lannea gum by compression coating

“…Core tablet earlier optimized was placed at the center on the polymer bed. Then, the remaining half of the coating contents were filled into the die and compressed with a 12 station rotary compression machine using circular flat punches to form a round CCT having the hardness in the range of 5-7 kg/cm 2 and a diameter of 8 mm (Latha et al, 2015).…”

“…It prevents the drug release from the inner core during the lag time. Various natural polymers such as Khaya/ Albizia gum (Odeku and Fell, 2005), Delinox regia gum/HPMC K 4M (Dabhi et al, 2010), xanthan gum/guar gum (Chickpetty et al, 2010), guar gum (Vemula and Bontha, 2013), Karaya gum (Latha et al, 2015), Anogeissus latifolia/ Gardenia gummifera (s), and thiolated ghatti gum (Puri et al, 2021) were formerly used as a coating polymers to delay the drug release from the core tablet during the lag time.…”

Formulation development and in-vitro evaluation of floating sintered matrix tablets of Cefpodoxime Proxetil using carnauba wax

“…These systems can be utilized to achieve either local or systemic effects. Osmotic pressure-activated drug delivery systems, which represent a novel generation of pharmaceuticals, have obtained regulatory approval for commercialization owing to their clinical benefits in comparison to sustainedrelease and quick-release products [1,2].…”

Development of Nanocrystal Compressed Minitablets for Chronotherapeutic Drug Delivery

“…The release pattern of the drug through this system is noted as sigmoid concerning time with a specific time gap to correlate with the associated disease. Chronobiology exerts influence on chronic conditions such as angina [ 5 , 6 , 7 ], asthma [ 8 , 9 , 10 ], hypertension, arthritis [ 11 , 12 ], etc., and the circumstances of such diseases get exacerbated in the medial night or prime hours in the morning [ 13 , 14 , 15 ].…”