Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review

Abstract

Type II diabetes mellitus is one of the most common public health problems worldwide. Its increasing prevalence in several countries and the difficult metabolic control of individuals with the disease justify studying strategies for primary prevention. The population has sought alternative and cheaper ways to treat the disease, including the use of plants considered medicinal by the population. In this study, we carried out a systematic review on the applicability of isolates and fractions of plant extracts in animal models in type II diabetes. A literature search was performed in MEDLINE/PubMed and Scopus databases. Studies using other experimental animals (horses, rabbits, and monkeys) and humans as well as articles in Chinese, German, and Russian were excluded. We assessed the quality of the studies included by using the criteria described in the ARRIVE guidelines. In general, the animals that received fractions or isolates presented reduced blood glucose levels, normalization of body weight and plasma insulin levels, and reduced total triglycerides and cholesterol. In addition, we observed wide variation among the analyzed parameters, which hindered comparison between the studies found. In further studies, standardized reports and experimental design would help to establish comparable study groups and advance the overall knowledge, thus facilitating translatability from animal data to human clinical conditions.

Mineral Analysis, In Vitro Evaluation of Alpha-Amylase, Alpha-Glucosidase, and Beta-Galactosidase Inhibition, and Antibacterial Activities of Juglans regia L. Bark Extracts

“…Pseudoiva from the region of Taza studied by our team under the same experimental conditions also showed a better correlation between the ABTS test of antioxidant activity and polyphenols [ 62 ]. These results are in agreement with previous studies that reported that phenolic compounds play an important role in scavenging free radicals and therefore may prevent the onset of diabetes disease [ 5 , 43 ]. Similarly, phenolic compounds have been shown to possess strong antibacterial activity [ 60 ].…”

“…However, recent studies have shown a significant increase in the number of children and adolescents with this disease, which may be associated with bad eating habits and a lack of physical activity. This leads to increasing rates of obesity, which is considered a risk condition for the development of type 2 diabetes [ 5 ].…”

“…Faced with this situation, the population has sought alternative and less expensive treatments for the diabetes disease, including the use of plants as a remedy for this disease, because the medicinal plant can have considerable hypoglycemic properties [ 5 ]. The literature analysis showed that several studies reported the benefits of different herbal treatments on several metabolic changes caused by type 2 diabetes.…”

Picrorhiza kurroa Enhances β-Cell Mass Proliferation and Insulin Secretion in Streptozotocin Evoked β-Cell Damage in Rats

“…Hence, alternative medications derived from medicinal herbs with potent hypoglycemic activity and minimal undesired complications are gaining importance. Ethnobotanical knowledge revealed that extracts and isolated molecules derived from medicinal plants have been widely used to treat type I and type II diabetes ( Sheikh et al, 2015 ; Coelho et al, 2016 ; Devi et al, 2016 ).…”

A study to evaluate the antidiabetic effect of Syzygium cumini Linn. seed extract in high fructose diet induced diabetes in Albino Rats

“…9,10 Therefore, this study was undertaken to evaluate antidiabetic effects of Syzygium cumini Linn. in euglycemic, and high fructose induced diabetes.…”