Applicability of radiocolloids, blue dyes and fluorescent indocyanine green to sentinel node biopsy in melanoma

Uhara, Hisashi; Yamazaki, Naoya; Takata, Minoru; Inoue, Yoshio; Sakakibara, Ayako; Nakamura, Yasuhiro; Suehiro, Keisuke; Yamamoto, Akifumi; Kamo, Riei; Mochida, Kosuke; Takenaka, Hideya; Yamashita, Toshiharu; Takenouchi, Tatsuya; Yoshikawa, Shusuke; Takahashi, Akira; Uehara, Jiro; Kawai, Mikio; Iwata, Hiroaki; Kadono, Takafumi; Kai, Yoshitaka; Watanabe, Shōichi; Murata, Satoru; Ikeda, Tetsuya; Fukamizu, Hidekazu; Tanaka, Toshihiro; Hatta, Naohito; Saida, Toshiaki

doi:10.1111/j.1346-8138.2011.01340.x

Cited by 37 publications

(26 citation statements)

References 8 publications

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“…Health Canada approval for clinical trial application for cervical injection of the mixture of the tracers for off-label use was obtained prior to initiation of the study. Despite there being no reports of toxicity of the utilization of ICG, 99mTc-SC, and blue dye in studies that utilized individual injection of all three tracers in patients with breast cancer or melanoma [20,21], patients were nonetheless informed of the possible theoretical risk of toxicity that could occur with injection of the mixture. Injection was performed following prepping of the patient under anesthesia and just prior to skin incision.…”

Section: Methodsmentioning

confidence: 99%

Comparing indocyanine green, technetium, and blue dye for sentinel lymph node mapping in endometrial cancer

How

Gotlieb

Press

et al. 2015

Gynecologic Oncology

146

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Section: Methodsmentioning

confidence: 99%

Comparing indocyanine green, technetium, and blue dye for sentinel lymph node mapping in endometrial cancer

How

Gotlieb

Press

et al. 2015

Gynecologic Oncology

146

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“…Scintigraphy with radiocolloids is extensively used in clinical practice because of the large availability of this radiotracer, commonly used to detect sentinel lymph node in breast cancer (11) and melanoma (12). It is employed in hepatosplenic disorders, due to its specific uptake in the reticulo-endothelial system by phagocytic Kuppfer's cells.…”

Section: Discussionmentioning

confidence: 99%

Pitfalls in oncology: a unique case of thoracic splenosis mimicking malignancy in a patient with resected breast cancer

Gelsomino¹,

Castellani²,

Marchianò³

et al. 2016

J. Thorac. Dis.

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Thoracic splenosis (TS) is a condition of autotransplantation of splenic tissue into the pleural cavity after thoraco-abdominal trauma, with diaphragmatic and spleen injury. It is usually asymptomatic and discovered as an incidental finding at imaging performed for other reasons. Its differential diagnosis regards different benign and malignant conditions and should be discerned avoiding invasive procedures. We report a case of thoracic mass associated with pleural nodules mimicking malignancy in a patient with resected breast cancer for whom a diagnosis of TS was made early by using non-invasive methods. Briefly, we review the literature data on TS, comment concisely the possible implications of using invasive procedures and describe the current non-invasive techniques available. Furthermore, we highlight the importance of an accurate medical history collection, the role of the multidisciplinary board and their impact on treatment decision making. Finally, we conclude that clinical information and imaging would be the discriminating factors to avoid unnecessary invasive procedures.

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“…[12][13][14] Other clinical applications of ICG are in assessment of cardiovascular and liver functions. 15,16 ICG has also been investigated in patients with breast, gastric, and skin cancer undergoing sentinel lymph node mapping, [17][18][19][20][21][22][23] and evaluation of lymphedema. 24,25 Despite its proven efficacy in these applications, the utility of ICG for broader clinical usage has been limited due to its nonspecific binding to albumin and high-density lipoproteins in plasma.…”

Section: Introductionmentioning

confidence: 99%

Effects of nanoencapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs

Bahmani¹,

Lytle²,

Walker³

et al. 2013

IJN

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Near-infrared nanoconstructs present a potentially effective platform for site-specific and deep tissue optical imaging and phototherapy. We have engineered a polymeric nanocapsule composed of polyallylamine hydrochloride (PAH) chains cross-linked with sodium phosphate and doped with indocyanine green (ICG) toward such endeavors. The ICG-doped nanocapsules were coated covalently with polyethylene glycol (5000 daltons) through reductive amination. We administrated the constructs by tail vein injection to healthy mice. To characterize the biodistribution of the constructs, we performed in vivo quantitative fluorescence imaging and subsequently analyzed the various extracted organs. Our results suggest that encapsulation of ICG in these PEGylated constructs is an effective approach to prolong the circulation time of ICG and delay its hepatic accumulation. Increased bioavailability of ICG, due to encapsulation, offers the potential of extending the clinical applications of ICG, which are currently limited due to rapid elimination of ICG from the vasculature. Our results also indicate that PAH and ICG-doped nanocapsules (ICG-NCs) are not cytotoxic at the levels used in this study.

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Applicability of radiocolloids, blue dyes and fluorescent indocyanine green to sentinel node biopsy in melanoma

Abstract: The patients with primary cutaneous melanoma underwent sentinel node (SN) mapping and biopsy at 25 facilities in Japan by the combination of radiocolloid with gamma probe and dye.

Cited by 37 publications

References 8 publications

Comparing indocyanine green, technetium, and blue dye for sentinel lymph node mapping in endometrial cancer

Comparing indocyanine green, technetium, and blue dye for sentinel lymph node mapping in endometrial cancer

Pitfalls in oncology: a unique case of thoracic splenosis mimicking malignancy in a patient with resected breast cancer

Effects of nanoencapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs

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