Application of 3D imaging in the real-time US–CT fusion navigation for minimal invasive tumor therapy

Wang

International Journal of Hyperthermia

et al. 2018

2018) Multiple antenna placement in microwave ablation assisted by a three-dimensional fusion image navigation system ABSTRACT Purpose: This study was conducted to compare a three-dimensional (3D) fusion image navigation system (FINS) with ultrasound (US) for guiding percutaneous microwave ablation (PMWA) for treatment of hepatocellular carcinoma (HCC). Materials and methods: This is a retrospective, non-randomized, comparative study. Our team developed a 3D FINS and used it to guide PMWAs for HCCs in 19 patients (3D group) and compared the results to those of 24 PMWAs guided by US (US group). The complete ablation rate of the first session, the local tumor progression (LTP), intrahepatic recurrence and disease-free survival were compared between the groups. Results: The 3D FINS was successfully applied in all 19 patients. The mean size of HCCs was 4.14 cm ±0.95 in 3D the group and 4.07 cm ±0.91 in the US group. Major complications were identified at 5.3% in the 3D group and 4.2% in the US group (p ¼ .865). Average time of image fusion was 404.53 ± 161.84 s. There were more antenna insertions in the 3D group (3.68 ± 1.57) than in the US group (2.71 ± 1.12) (p ¼ .02). The complete ablation rate of the first session was higher in the 3D group (94.7%) than in the US group (62.5%) (p ¼ .034). The mean follow-up period was 11.4 months ±4.9 in the 3D group and 9.8 months ±5.5 in the US group. There were no significant differences in technique efficacy rate and LTP rate between the two groups. Conclusions: The 3D FINS could be a safe, feasible and effective technique for guiding PMWA of HCC, which could help an operator improve the complete ablation rate of the first session. ARTICLE HISTORY

Section: Electromagnetic Tracking Devicementioning

confidence: 65%

“…In previous studies [26][27][28][29][30], our research group developed and presented a 3D navigation software system that was applied to perform relevant experimental studies. These previous studies demonstrated that the navigation software could satisfy the clinical requirements of effectiveness, stability and security.…”

Section: Self-developed 3d Finsmentioning

confidence: 99%

Multiple antenna placement in microwave ablation assisted by a three-dimensional fusion image navigation system for hepatocellular carcinoma

Wang

International Journal of Hyperthermia

et al. 2018

International Journal of Hyperthermia

“…Our group developed 3D visualisation preoperative planning software that included tumour segmentation, simulation of ablation volume, access-path planning, and visualisation of both the patient anatomy and planned strategy [14,18]. The imaging data were imported into the EFILM software and were analysed by the 3D visualisation platform.…”

Section: D Visualisation Operative Treatment Planning and Microwave mentioning

confidence: 99%

“…Traditionally, 2-dimensional imaging can provide valuable information about the anatomical structure, but it lacks the spatial positioning information of volumetric data that clinicians must know for minimally invasive treatment. The results of human error, such as weakness in spatial sense and imperfect hand-eye coordination, often lead to imprecise needle positioning [14]. 3D visualisation preoperative planning can display the location and relationships of the tumour with surrounding tissues, predict the time-temperature profile during ablation, improve surgical skills and the safety of surgery, reduce surgical complications and promote better long-time prognoses [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Combination therapy of three-dimensional (3D) visualisation operative treatment planning system and US-guided percutaneous microwave ablation in larger renal cell carcinomas (D ≥ 4 cm): preliminary results

Liang

et al. 2016

Self Cite

Materials and methods:The results from 20 patients with 20 larger RCCs treated with a 3D visualisation operative treatment planning system and US-guided PMWA were reviewed retrospectively. The patients were followed up by contrast-enhanced images at 1, 3, and 6 months and every 6 months thereafter. The outcomes of overall survival and local tumour progression rate were statistically analysed. Results: The median follow-up period was 26 months. The mean time of ablation for one tumour was 1.1 ± 0.3 sessions. The average number of ablation points of one tumour was 4.5 ± 0.9. The mean output power of ablation was 50.50 ± 2.2 W. The mean time of ablation for one tumour was 1374.4 ± 391.1 s. Artificial ascites was used in 12 (60%) tumours adjacent to the intestinal tract, and thermal monitoring system was used in all tumours (100%). Technical effectiveness and metastasis-free status were achieved in all tumours. The 1-and 2-year local tumour progression rates were both 5%. The cancer-specific survival rate and 2-year overall survival rates were both 100%. No severe major complications occurred. There was no significant difference in creatinine or urea nitrogen before or 3 days after ablation. Conclusions: Combination therapy of 3D visualisation operative treatment planning system and USguided PMWA appeared to be a safe and effective technique for the management of larger RCCs, which could improve clinical efficacy. ARTICLE HISTORY

Chinese Medical Journal

“…[45] First, locating tumors using CT/MRI scans and then making an alignment and fusion with real-time ultrasound examination that accomplishes real-time needle biopsy guidance for precise location puncture of isolated tumors, real-time ultrasound imaging can also be used to monitor tumor ablation under fusion imaging mode, which avoids damage to surrounding tissues. [46] Liu et al . [47] showed that all 18 target hepatocellular carcinoma (HCC) nodules could be detected with fusion images in all patients, but could not be detected on conventional ultrasound.…”

Section: Ultrasound-computed Tomography/magnetic Resonance Imaging Fumentioning

confidence: 99%

Application of Multimodality Imaging Fusion Technology in Diagnosis and Treatment of Malignant Tumors under the Precision Medicine Plan

Wang

Chen

et al. 2016

Objective:The arrival of precision medicine plan brings new opportunities and challenges for patients undergoing precision diagnosis and treatment of malignant tumors. With the development of medical imaging, information on different modality imaging can be integrated and comprehensively analyzed by imaging fusion system. This review aimed to update the application of multimodality imaging fusion technology in the precise diagnosis and treatment of malignant tumors under the precision medicine plan. We introduced several multimodality imaging fusion technologies and their application to the diagnosis and treatment of malignant tumors in clinical practice.Date Sources:The data cited in this review were obtained mainly from the PubMed database from 1996 to 2016, using the keywords of “precision medicine”, “fusion imaging”, “multimodality”, and “tumor diagnosis and treatment”.Study Selection:Original articles, clinical practice, reviews, and other relevant literatures published in English were reviewed. Papers focusing on precision medicine, fusion imaging, multimodality, and tumor diagnosis and treatment were selected. Duplicated papers were excluded.Results:Multimodality imaging fusion technology plays an important role in tumor diagnosis and treatment under the precision medicine plan, such as accurate location, qualitative diagnosis, tumor staging, treatment plan design, and real-time intraoperative monitoring. Multimodality imaging fusion systems could provide more imaging information of tumors from different dimensions and angles, thereby offing strong technical support for the implementation of precision oncology.Conclusion:Under the precision medicine plan, personalized treatment of tumors is a distinct possibility. We believe that multimodality imaging fusion technology will find an increasingly wide application in clinical practice.