Application of a magnetic molecularly imprinted polymer for the selective extraction and trace detection of lamotrigine in urine and plasma samples

Abstract

Magnetic molecularly imprinted polymers have been synthesized for the selective preconcentration and trace determination of lamotrigine (LTG) in urine and plasma samples. The magnetic nanoparticles were modified by tetraethyl orthosilicate and 3-methacryloxypropyl trimethoxysilane before imprinting. The magnetic molecularly imprinted polymers were prepared via surface molecular imprinting technique, using Fe3 O4 as a magnetic component, LTG as template molecule, methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and 2,2'-azobisisobutyronitrile as a radical initiator in methanol/acetonitrile (50:50, v/v) as the porogen. The obtained sorbent was characterized using scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, and thermal analysis. Separation of the sorbent from the sample solution was simply achieved by applying an external magnetic field. Determination of the extracted drug was performed by high-performance liquid chromatography with UV detection. Under the optimum extraction conditions, the method detection limits were 0.7 μg/L (based on S/N of 3) for urine samples and 0.5 μg/L for plasma samples. A linear dynamic range of 1-1000 μg/L was obtained for LTF in plasma and urine samples. Finally, the applicability of the proposed method was evaluated by extraction and determination of LTG in urine and plasma samples.

Preparation, characterization and electrochemical application of Ag–ZnO nanoplates for voltammetric determination of glutathione and tryptophan using modified carbon paste electrode

“…Their applications in the area of agriculture and food are relatively scarce compared to their use in the field of drug delivery and pharmaceuticals [36][37][38][39][40]. The high performance of nanoparticles is due to their high surface area/volume ratio [41].…”

Application of Ion-Imprinted Polymer Nanoparticles for Selective Trace Determination of Palladium Ions in Food and Environmental Samples with the Aid of Experimental Design Methodology

“…Different solid phases such as activated carbon (Chakrapani et al 2001), polyurethane foam (Kang and Lee 1983), amberlite XAD resins (Elci et al 2003), and modified silica gel (Tokalioglu et al 2004) have been used for preconcentration-determination of palladium. Based on the idea of molecular imprinting technique (Omidi et al 2014a, b;Behbahani et al 2014e), ion-imprinted polymers (IIPs) have attracted much attention as selective sorbents for preconcentration of metal ions (Behbahani et al 2014f;Ebrahimzadeh and Behbahani 2013). In ion-imprinting techniques, the ion-ligand complex serves as a template.…”

Solid phase extraction and trace monitoring of cadmium ions in environmental water and food samples based on modified magnetic nanoporous silica

“…However, mesoporous silica powders are difficult to be separated and recovered because of their small sizes, which hinder their utilization in liquid-solid processes. On the other hand, magnetic nanoparticles have been intensively investigated in recent years [25][26][27][28]. A novel materials can be obtained by combining mesoporous silica materials with magnetic nanoparticles.…”