Application of a new Cl-plasma-treated Ag/AgCl reference electrode to micromachined glucose sensor

Park, Se-Ik; Jun, Sang Beom; Park, Se Jin; Kim, Hee Chan; Kim, S.J.

doi:10.1109/jsen.2003.814649

Cited by 33 publications

(3 citation statements)

References 14 publications

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“…Such devices are miniaturized, leading to improved measurement time response and minimized invasiveness. MEMS or related technologies have previously been applied for glucose sensors that are based on electrochemical [22][23][24][25], eletrophoretic [26], thermal [27][28][29], optical [30] and colorimetric [31] detection methods. MEMS-based devices have also exploited microdialysis [32,33] and glucose-induced hydrogel swelling [34].…”

Section: Introductionmentioning

confidence: 99%

A MEMS viscometric sensor for continuous glucose monitoring

Zhao¹,

Li²,

Davidson³

et al. 2007

J. Micromech. Microeng.

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We present a MEMS sensor aiming to enable continuous monitoring of glucose levels in diabetes patients. The device features a magnetically-driven vibrating microcantilever, which is situated in a microchamber and separated from the environment by a semi-permeable membrane. Glucose sensing is based on affinity binding principles using a solution of dextran concanavalin-A (Con A) as the sensing fluid. The glucose concentration is determined by detecting viscosity changes induced by the binding of glucose to Con A through the measurement of the cantilever's vibration parameters. The device is capable of measuring physiologically relevant glucose concentrations from 0 to 25 mM with a resolution better than 0.025 mM and a phase sensitivity better than 0.4 • mM −1. The response of the sensor to glucose concentration changes has a time constant down to 4.27 min, and can be further improved with optimized device designs.

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Section: Introductionmentioning

confidence: 99%

A MEMS viscometric sensor for continuous glucose monitoring

Zhao¹,

Li²,

Davidson³

et al. 2007

J. Micromech. Microeng.

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show abstract

Section: Introductionmentioning

confidence: 99%

Continuous Glucose Monitoring

2013

2013 Compendium of Clinical Practice Guidelines

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We present a MEMS sensor aiming to enable continuous monitoring of glucose levels in diabetes patients. The device features a magnetically-driven vibrating microcantilever, which is situated in a microchamber and separated from the environment by a semi-permeable membrane. Glucose sensing is based on affinity binding principles using a solution of dextran concanavalin-A (Con A) as the sensing fluid. The glucose concentration is determined by detecting viscosity changes induced by the binding of glucose to Con A through the measurement of the cantilever's vibration parameters. The device is capable of measuring physiologically relevant glucose concentrations from 0 to 25 mM with a resolution better than 0.025 mM and a phase sensitivity better than 0.4 • mM −1 . The response of the sensor to glucose concentration changes has a time constant down to 4.27 min, and can be further improved with optimized device designs.

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“…The location of the largest peak in the pattern is at about 2𝜃 = 32.5 ∘ . [9] The potential of Ag/AgCl microneedle array was measured against a saturated calomel electrode (SCE) in 1 M KCl solution. A high in-put impedance electrometer was used to measure the potential difference between the electrodes.…”

mentioning

confidence: 99%

Fabrication of Dry Electrode for Recording Bio-potentials

Wang¹,

Guo²,

Gui³

et al. 2011

Chinese Phys. Lett.

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Development of minimally invasive dry electrodes for recording biopotentials is presented. The detailed fabrication process is outlined. A dry electrode is formed by a number of microneedles. The lengths of the microneedles are about 150 𝜇m and the diameters are about 50 𝜇m. The tips of the microneedles are sharp enough to penetrate into the skin. The silver/silver chloride is grown on microneedle arrays and demonstrates good character. The electrocardiogram shows that the dry electrode is suitable for recording biopotentials.

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Application of a new Cl-plasma-treated Ag/AgCl reference electrode to micromachined glucose sensor

Cited by 33 publications

References 14 publications

A MEMS viscometric sensor for continuous glucose monitoring

A MEMS viscometric sensor for continuous glucose monitoring

Continuous Glucose Monitoring

Fabrication of Dry Electrode for Recording Bio-potentials

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