Application of Advanced Technologies in Natural Product Research: A Review with Special Emphasis on ADMET Profiling

Abstract

: The successful conversion of natural products (NPs) into lead compounds and novel pharmacophores have emboldened the researchers to harness the drug discovery process with lot more enthusiasm. However, forfeit of bioactive NPs resulting from overabundance of metabolites and their wide dynamic range have created the bottleneck in NP researches. Similarly, existence of multidimensional challenges including evaluation of pharmacokinetics, pharmacodynamics, and safety parameters has been a concerned issue for many. Advancement of technology has brought the evolution of traditional natural product researches into the computer-based assessment exhibiting pretentious remarks about their efficiency in the drug discovery. The early attention to the quality of the NPs may reduce the attrition rate of drug candidates by parallel assessment of ADMET profiling. This article reviews the status, challenges, opportunities, and integration of advanced technologies in natural product research. Indeed, emphasis will be on current and futuristic direction towards the application of newer technologies in early-stage ADMET profiling of bioactive moieties from the natural sources. It can be expected that combinatorial approaches in ADMET profiling will fortify the Natural Product-based drug discovery in the near future.

Virtual Screening of a Series of Phytocompounds from Lagenaria Siceraria for the Identification of Potential Antidiabetic Drug Candidates, in Silico Study and Drug Design Approaches

“…In modern years, the in silico ADMET studies of potential bioactive compounds have been exploited in drug development as a main screening technique for the early discovery phase [51,52]. Early ADMET research screening may lower the risk of failure during the clinical study [53]. The pkCSM is one of the greatest predictors of these necessary ADMET data [54].…”

Characterization of the structure, stability, and activity of hypoglycemic peptides fromMoringa oleiferaseed protein hydrolysates

“…Many drugs and plants can lower blood glucose by altering the expression of insulin-related proteins. 50,51 Western blotting of the relative protein expression levels of PI3K and AMPK was conducted (Fig. 7A and B).…”

Metabolism and Bioavailability of Olive Bioactive Constituents Based on In Vitro, In Vivo and Human Studies

“…Additionally, pharmacokinetics (PK) are incorporated into determining the fate of a compound in in vivo systems through the investigation of compound absorption, distribution, metabolism and excretion (and toxicity) or ADME(T) studies [31]. The key element in these studies is the investigation of metabolism, the process by which xenobiotics (in our study's case, OBs as pure chemical entities, food constituents, enriched extracts or supplements) and endogenous metabolites are converted enzymatically into more hydrophilic and easily excreted compounds [32]. Formed or biotransformed metabolites of the parent molecule might possess similar or different activity or even potential toxicity [32].…”

“…The key element in these studies is the investigation of metabolism, the process by which xenobiotics (in our study's case, OBs as pure chemical entities, food constituents, enriched extracts or supplements) and endogenous metabolites are converted enzymatically into more hydrophilic and easily excreted compounds [32]. Formed or biotransformed metabolites of the parent molecule might possess similar or different activity or even potential toxicity [32]. Such studies are fundamental in a drug's development process.…”