Application of an Intraoperative Neuromonitoring System Using a Surface Pressure Sensor in Parotid Surgery: A Rabbit Model Study

Sung, Eui‐Suk; Kwon, Hyun-Keun; Shin, Sung‐Chan; Cheon, Young-Il; Lee, Jungwoo; Park, Da-Hee; Choi, Sun Ha; Kim, Hwa-Bin; Park, Hye-Jin; Lee, Jin‐Choon; Ro, Jung Hoon; Lee, Byung‐Joo

doi:10.21053/ceo.2019.01900

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…The first parotidectomy with facial nerve monitoring was described in 1990 [ 25 ]. In recent decades, the use of NIM has increased significantly to prevent facial nerve damage [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Surgical management of Warthin tumor: long-term follow-up of 224 patients from 2002 to 2018

Bonavolontà

Germano

Committeri

et al. 2023

Oral Maxillofac Surg

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Purpose Warthin tumors (WT) are the second most common benign parotid gland neoplasms. They can occur as synchronous or metachronous lesions in 6–10% of cases. This study aims to compare the complication rate in 224 patients who underwent extracapsular dissection (ECD) or superficial parotidectomy (SP) for the treatment of a WT. Methods This retrospective study was conducted at the Department of Maxillo-Facial Surgery at the University of Naples “Federico II” from February 2002 to December 2018 on a group of patients who underwent surgical treatment for WT. The type of surgical technique was chosen based on Quer’s classification. The complications evaluated were facial nerve palsy, hematoma, Frey’s syndrome, and bleeding. Results A total of 224 patients treated from 2002 to 2018 for Warthin tumor were included in the study. Two hundred elven had solitary tumors (94.1%) and 13 had multicentric lesions (5.8%), of which 9 cases presented synchronous lesions and 4 cases presented metachronous lesions. Extracapsular dissection (ECD) was performed in 130 patients (58.3% of cases) and superficial parotidectomy (SP) in the other 94 (41.7% of cases). Conclusions We consider both surgical techniques as valid. In our opinion, it is essential to study each case based on Quer’s Classification to obtain the best surgical outcome. Based on a lower observed rate of complications such as facial nerve palsy, Frey’s syndrome, and bleeding, ECD seems to be the best option for the surgical treatment of Quer Class I lesions.

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“…The first parotidectomy with facial nerve monitoring was described in 1990 [ 25 ]. In recent decades, the use of NIM has increased significantly to prevent facial nerve damage [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Surgical management of Warthin tumor: long-term follow-up of 224 patients from 2002 to 2018

Bonavolontà

Germano

Committeri

et al. 2023

Oral Maxillofac Surg

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LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion

Liu,

et al. 2024

J Headache Pain

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Background Trigeminal nerve injury is one of the most serious complications in oral clinics, and the subsequent chronic orofacial pain is a consumptive disease. Increasing evidence demonstrates long non-coding RNAs (lncRNAs) play an important role in the pathological process of neuropathic pain. This study aims to explore the function and mechanism of LncRNA Anxa10-203 in the development of orofacial neuropathic pain. Methods A mouse model of orofacial neuropathic pain was established by chronic constriction injury of the infraorbital nerve (CCI-ION). The Von Frey test was applied to evaluate hypersensitivity of mice. RT-qPCR and/or Western Blot were performed to analyze the expression of Anxa10-203, DHX30, and MC1R. Cellular localization of target genes was verified by immunofluorescence and RNA fluorescence in situ hybridization. RNA pull-down and RNA immunoprecipitation were used to detect the interaction between the target molecules. Electrophysiology was employed to assess the intrinsic excitability of TG neurons (TGNs) in vitro. Results Anxa10-203 was upregulated in the TG of CCI-ION mice, and knockdown of Anxa10-203 relieved neuropathic pain. Structurally, Anxa10-203 was located in the cytoplasm of TGNs. Mechanistically, Mc1r expression was positively correlated with Anxa10-203 and was identified as the functional target of Anxa10-203. Besides, Anxa10-203 recruited RNA binding protein DHX30 and formed the Anxa10-203/DHX30 complex to enhance the stability of Mc1r mRNA, resulting in the upregulation of MC1R, which contributed to the enhancement of the intrinsic activity of TGNs in vitro and orofacial neuropathic pain in vivo. Conclusions LncRNA Anxa10-203 in the TG played an important role in orofacial neuropathic pain and mediated mechanical allodynia in CCI-ION mice by binding with DHX30 to upregulate MC1R expression. Graphical Abstract The up-regulated lncRNA Anxa10-203 in the trigeminal ganglion of CCI-ION mice interacts with DHX30 to contribute to the excitability of TG neurons and orofacial pain by enhancing Mc1r mRNA stability.

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Application of an Intraoperative Neuromonitoring System Using a Surface Pressure Sensor in Parotid Surgery: A Rabbit Model Study

Cited by 2 publications

References 22 publications

Surgical management of Warthin tumor: long-term follow-up of 224 patients from 2002 to 2018

Surgical management of Warthin tumor: long-term follow-up of 224 patients from 2002 to 2018

LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion

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