SUMMARYRecently, frequency-domain equalization (FDE) has been attracting much attention as a way to improve single-carrier (SC) signal transmission in a frequency-selective wireless channel. Since the SC signal spectrum is spread over the entire signal bandwidth, FDE can take advantage of channel frequency-selectivity and achieve the frequency diversity gain. SC with FDE is a promising wireless signal transmission technique. In this article, we review the pioneering research done on SC with FDE. The principles of simple one-tap FDE, channel estimation, and residual intersymbol interference (ISI) cancellation are presented. Multi-input/multioutput (MIMO) is an important technique to improve the transmission performance. Some of the studies on MIMO/SC with FDE are introduced.