Application of Antimicrobial Polymers in the Development of Dental Resin Composite

Abstract

Dental resin composites have been widely used in a variety of direct and indirect dental restorations due to their aesthetic properties compared to amalgams and similar metals. Despite the fact that dental resin composites can contribute similar mechanical properties, they are more likely to have microbial accumulations leading to secondary caries. Therefore, the effective and long-lasting antimicrobial properties of dental resin composites are of great significance to their clinical applications. The approaches of ascribing antimicrobial properties to the resin composites may be divided into two types: The filler-type and the resin-type. In this review, the resin-type approaches were highlighted. Focusing on the antimicrobial polymers used in dental resin composites, their chemical structures, mechanical properties, antimicrobial effectiveness, releasing profile, and biocompatibility were included, and challenges, as well as future perspectives, were also discussed.

Adhesive Ability of Different Oral Pathogens to Various Dental Materials: An in Vitro Study

“…Another effective way to increase the antimicrobial properties of materials is to fix antimicrobial components on the surface of biological materials to maintain their antimicrobial efficacy. Therefore, it is possible to incorporate antibacterial ingredients into composite resin to modify them so that the bacteria will be inactivated when they contact the modified resin, inhibiting biofilm formation [35][36][37] . However, further observations are necessary to determine whether these modifications can significantly affect dynamic clinical conditions [38] .…”

The Antibacterial and Remineralizing Effects of Biomaterials Combined with DMAHDM Nanocomposite: A Systematic Review

“…When copolymerized in resins, quaternary ammonium methacrylates (QAMs), which are cationic compounds, exhibit low toxicity and a broad-spectrum antimicrobial effect [ 2 , 10 , 11 , 12 ]. These positively charged methacrylic monomers bind and disrupt the electrical equilibrium of the negatively charged bacterial membranes thereby causing rupture and cell death [ 13 ].…”

“…Due to the strong antibacterial properties of DMAHDM, researchers have experimented with combining additional biomaterials with DMAHDM to explore any synergistic mechanisms of action to increase the efficacy of DMAHDM and reduce biofilm formation at the tooth-restoration interface [ 8 , 11 ]. DMAHDM does not possess any inherent remineralizing capabilities, so efforts have also been made to incorporate biomaterials that promote tooth remineralization as another approach for caries inhibition [ 1 , 8 , 22 ].…”

Research on Silicone Methacrylates Containing Dental Resins With Anti-adhesion Effect Against S. Mutans and Resistance to Mucin Adsorption

“…Besides the characteristics of fillers, properties of DRCs are mainly influenced by the monomeric composition of resin matrix [8]. For the purpose of achieving long-term biofilm inhibition, several methacrylate monomers with antibacterial groups such as quaternary ammonium have been synthesized and incorporated into dental resins as polymerizable antibacterial agents [9][10][11]. These agents immobilize antibacterial groups into polymeric network by covalent bonds, thus could endow dental resins with long-last antibacterial activity [12].…”