Application of Antiviral Polyoxometalates to Living Environments—Antiviral Moist Hand Towels and Stationery Items

Abstract

Safe, secure, and environmentally friendly active substances should be developed. VB (virus block) refers to an antibacterial/antiviral mixture of two kinds of polyoxometalates (PMs), i.e., K11H[(VO)3(SbW9O33)2]·27H2O (VB2) and α-Na2[SbW9O33]9− (VB3), and polyhexamethylene biguanide (PHMB). VB was demonstrated to exert antiviral effects on cultured cells. The effects were maintained even in hygiene products or solids. The antiviral effects were analyzed by reverse transcription–polymerase chain reaction (RT–PCR), and the results were correlated with TCID50, potentially eliminating the need for handling infectious viruses. VB was demonstrated to be extremely effective (up to 99.99% inhibition) in cultured cells, with antibacterial/antiviral effects maintained in VB-containing hygiene products. VB was applied to solids, demonstrating their high applicability and versatility. VB withstands high temperatures regardless of materials because its effects are enhanced by more frequent contact with viruses and bacteria due to the increased surface area of the compound.

Impact of different spacers on the conjugation between Anderson-Evans polyoxometalates and peptides

“…Polyoxometalates (POMs), a class of polynuclear oxo-bridged transition metal complexes (Blazevic and Rompel, 2016), have received extensive attention due to their rich topology and tunable chemical and physical properties. In addition to their application in multidisciplinary fields (Omwoma et al, 2015), such as material science (Yu et al, 2023) and catalysis (Wang and Yang, 2015), their biomedical activity OPEN ACCESS EDITED BY (Čolović et al, 2020), as antitumor (Bijelic et al, 2019), antiviral (Dan et al, 2020), and antibacterial (Bijelic et al, 2018) agents, has been highlighted. The main advantage of POMs is that their properties (especially dimensions and charge) can be tailored to optimize the interaction with biological macromolecules (Arefian et al, 2017;Lentink et al, 2023).…”

Anti-Aging Effects of Polyoxometalates on Skin

“…We previously identified 2 PMs (VB2 and VB3) with strong anti-bacterial and anti-viral activities and demonstrated that they inhibited the adhesion and invasion of viruses into cells by binding to viral particles [19]. The development of products with excellent hygienic properties may be possible by incorporating stable and anti-microbial PMs into materials [20].…”