Application of autologous bone marrow stem cells in the therapy of spinal cord injury patients

Abstract

We studied the safety and efficiency of transplantation of autologous bone marrow cells in complex therapy of patients with spinal cord injury in the late period of the disease. In control group patients, meningomyeloradiculolis was performed, while in the main group surgical treatment was supplemented by transplantation of autologous bone marrow cells. Transplantation of BM stem cells into the cyst cavity and intravenously was well tolerated, did not cause allergic or inflammatory reactions in the early and delayed periods after surgery, and did not induce the formation of ossification foci in the nervous tissue. Analysis of the neurological status by ASIA, Bartel, and Ashworth scales showed that in the main group the positive clinical dynamics was more often observed than in the control. The decrease in neurological deficit included improvement of sensory and motor activity and conducting sensory function. Thus, transplantation of autologous bone marrow cells can be a novel safe strategy for the treatment of patients in the late period after spinal trauma.

A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury

“…This and the easy access to BMSCs for autotransplantation explains their use in several human treatment studies using a mixture of BMSCs and hematopoietic (mononuclear) cells (Callera et al, 2006;Chernykh et al, 2007;Saito et al, 2008;Yoon et al, 2007). Unfortunately, these reports included small patient cohorts only, used uncharacterized mixtures of bone-marrow cells, and were mostly not controlled.…”

Stem Cells: New Hope For Spinal Cord Injury

“…No serious complications were reported, and 30.4% of patients who received MSCs at acute and subacute stages showed significant improvements in their ASIA scale position (27). Few clinical studies have shown neurological improvements in MSC-treated patients who during the chronic stage of SCI, when the glial scar is already present (28,29,30,31,32). In these studies, MSCs were transplanted directly into the lesion intrathecally, intravenously and intrathecally (simultaneously) at once, and intraarterially.…”

Cell Therapy of Stroke and Spinal Cord Injury Complications

“…Тем не менее, в большинстве недавних кли-нических испытаний используются МСК [38][39][40][41]. Так, Chernykh и соавт [38], как и другие исследователи [39][40][41], использовали аутоло-гичные МСК из костного мозга для терапии спинальной травмы.…”

“…Так, Chernykh и соавт [38], как и другие исследователи [39][40][41], использовали аутоло-гичные МСК из костного мозга для терапии спинальной травмы. Когда исследователи сравнили клинические результаты с контроль-ной группой, они сообщили об улучшении по-казателей по шкалам ASIA, Barthel и Ashworth у 66% пациентов [38].…”