Application of bile acids in drug formulation and delivery

Stojančević, Maja; Pavlović, Nebojša; Goločorbin-Kon, Svetlana; Mikov, Momir

doi:10.1080/21553769.2013.879925

Cited by 121 publications

(75 citation statements)

References 71 publications

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“…Unique features of BAs, including their chiral and rigid framework and different reactivity of their hydroxyl groups, have rendered them attractive model molecules for the design of synthetic receptors. Their ability to act as drug carriers through the formation of mixed micelles and bilosomes, and their facile conjugation with other molecules, led to their use as carriers for drug delivery [11]. Drugs can be coupled to BAs either at one of the three hydroxyl groups at positions 3, 7 or 12, or to the carboxyl group at position C-24.…”

Section: Cyp7a1mentioning

confidence: 99%

Steroid-photosensitizer conjugates: Syntheses and applications

Osati

Ali

Guérin

et al. 2017

J. Porphyrins Phthalocyanines

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This review focuses on progress in the development of different approaches to the design of steroid ([Formula: see text] estrogens, androgens, cholesterol) conjugates with coordination assemblies of metalloporphyrins, phthalocyanines and related complexes. Porphyrins and phthalocyanines have received considerable attention due to their novel composition, intriguing spectroscopic, photophysical, and redox properties, and potential application in light-harvesting and optoelectronic devices. With the development of more efficient imaging and therapeutic applications, these bio-conjugates are evaluated as multimodality agents (PET, fluorescence imaging) to monitor the mechanism of action of biologically active components in living systems and as agents for molecular recognition, oxygen atom transfer and catalysis. The tetrapyrrole components, which can be coupled via covalent and various non-covalent linkages, may exhibit strong interactions through efficient photo-induced electron and/or energy transfer processes.

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Section: Cyp7a1mentioning

confidence: 99%

Steroid-photosensitizer conjugates: Syntheses and applications

Osati

Ali

Guérin

et al. 2017

J. Porphyrins Phthalocyanines

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“…Bile acids were selected in our micelle formulation because they are biological surfactants naturally produced in humans and known to be beneficial for human health. 24 Moreover, compared to other ordinary aliphatic surfactants, bile acids show absorption enhancement for drug delivery and a unique ability to facilitate drug permeation through biological membranes. 25,26 We hypothesized that the addition of NaC to mPEG-PDLLA would improve the stability of PTX in micelles and enhance the accumulation of PTX in tumor tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that when combined with bile acids, amphiphilic drugs usually have low CMC and better solubilization capacity than the individual components, due to synergistic interactions. 24 Therefore, the low CMC value of CMs was the result of synergistic interactions between NaC and mPEG-PDLLA, suggesting CMs may be more stable than micelles for anticancer drug delivery.…”

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confidence: 99%

“…67,68 More importantly, micelles containing NaC showed unique tumor-targeting capability, which greatly improved the antitumor effect. 17,23,24 The safety and toxicity of PTX-CMs were comprehensively investigated in this work. Because polysorbate 80 (Tween 80) used in PTX injection caused hemolysis 69 and NaC is also a surfactant that has similar property as Tween 80, the hemolytic activity of PTX-CMs was studied.…”

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confidence: 99%

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Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel

Zhang¹,

Wu²,

Zhang³

et al. 2017

IJN

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Purpose Polymeric micelles are attractive nanocarriers for tumor-targeted delivery of paclitaxel (PTX). High antitumor efficacy and low toxicity require that PTX mainly accumulated in tumors with little drug exposure to normal tissues. However, many PTX-loaded micelle formulations suffer from low stability, fast drug release, and lack of tumor-targeting capability in the circulation. To overcome these challenges, we developed a micellar formulation that consists of sodium cholate (NaC) and monomethoxy poly (ethylene glycol)- block -poly ( d , l -lactide) (mPEG-PDLLA). Methods PTX-loaded NaC-mPEG-PDLLA micelles (PTX-CMs) and PTX-loaded mPEG-PDLLA micelles (PTX-Ms) were formulated, and their characteristics, particle size, surface morphology, release behavior in vitro, pharmacokinetics and in vivo biodistributions were researched. In vitro and in vivo tumor inhibition effects were systematically investigated. Furthermore, the hemolysis and acute toxicity of PTX-CMs were also evaluated. Results The size of PTX-CMs was 53.61±0.75 nm and the ζ-potential was −19.73±0.68 mV. PTX was released much slower from PTX-CMs than PTX-Ms in vitro. Compared with PTX-Ms, the cellular uptake of PTX-CMs was significantly reduced in macrophages and significantly increased in human cancer cells, and therefore, PTX-CMs showed strong growth inhibitory effects on human cancer cells. In vivo, the plasma AUC 0−t of PTX-CMs was 1.8-fold higher than that of PTX-Ms, and 5.2-fold higher than that of Taxol. The biodistribution study indicated that more PTX-CMs were accumulated in tumor than PTX-Ms and Taxol. Furthermore, the significant antitumor efficacy of PTX-CMs was observed in mice bearing BEL-7402 hepatocellular carcinoma and A549 lung carcinoma. Results from drug safety assessment studies including acute toxicity and hemolysis test revealed that the PTX-CMs were safe for in vivo applications. Conclusion These results strongly revealed that NaC-mPEG-PDLLA micelles can tumor-target delivery of PTX and enhance drug penetration in tumor, suggesting that NaC-mPEG-PDLLA micelles are promising nanocarrier systems for anticancer drugs delivery.

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“…The important role of bile salts in the assimilation and delivery of drugs was discussed in reviews. [9,10] The solubilization of magnesium octa[(4'-benzo-15-crown-5)-oxy]phthalocyanine (Mgcr 8 Pc) in micellar solutions of SDC [11] ensures the embedding of Mgcr 8 Pc (Figure 1) into supramolecular gels of SDC [12] at the values of pH and ionic strength close to environment-friendly physiological ones.…”

mentioning

confidence: 99%

Сrown- and Sulfophthalocyanines in Low-Molecular-Weight Hydrogels: Properties, Molecular State, and Release

Gol’dshleger¹,

Лобач²,

Дремова³

et al. 2017

MHC

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In continuation of our previous studies, we explored the solubilization of crown-and sulfophthalocyanines in the presence of bile salts (BS),Ключевые слова: Металлофталоцианины, краун-эфиры, биосовместимость, соли желчных кислот, солюбилизация, низкомолекулярные гидрогели, высвобождение, аминокислоты, спектры поглощения.

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Application of bile acids in drug formulation and delivery

Cited by 121 publications

References 71 publications

Steroid-photosensitizer conjugates: Syntheses and applications

Steroid-photosensitizer conjugates: Syntheses and applications

Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel

Сrown- and Sulfophthalocyanines in Low-Molecular-Weight Hydrogels: Properties, Molecular State, and Release

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