Application of BOLD MRI and DTI for the evaluation of renal effect related to viscosity of iodinated contrast agent in a rat model

Wang, Yi; Kawaguchi, Ren; Liu, Yi; Sun, Wei; Wang, Jiahuan; Zhang, Xin; Wu, Chenghua

doi:10.1002/jmri.25683

Cited by 18 publications

(16 citation statements)

References 32 publications

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“…In addition, intravoxel incoherent motion (IVIM) imaging could detect the diffusion of water molecules and perfusion-dependent diffusion in vivo (12131415). Previous studies have reported that a decrease in pure molecular diffusion coefficient (D), pseudo-diffusion coefficient (D * ), and perfusion fraction (f) values was detected when IVIM imaging was conducted on CI-AKI rat models while an increase in apparent transverse relaxation rate (R2 * ) values was detected when BOLD imaging was conducted on contrast-induced rat models (1216).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging

et al. 2019

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Objective To examine the potential of intravoxel incoherent motion (IVIM) and blood oxygen level-dependent (BOLD) magnetic resonance imaging for detecting renal changes after iodinated contrast-induced acute kidney injury (CI-AKI) development in a diabetic rabbit model. Materials and Methods Sixty-two rabbits were randomized into 2 groups: diabetic rabbits with the contrast agent (DCA) and healthy rabbits with the contrast agent (NCA). In each group, 6 rabbits underwent IVIM and BOLD imaging at 1 hour, 1 day, 2 days, 3 days, and 4 days after an iohexol injection while 5 rabbits were selected to undergo blood and histological examinations at these specific time points. Iohexol was administrated at a dose of 2.5 g I/kg of body weight. Further, the apparent transverse relaxation rate (R2 * ), average pure molecular diffusion coefficient (D), pseudo-diffusion coefficient (D * ), and perfusion fraction (f) were calculated. Results The D and f values of the renal cortex (CO) and outer medulla (OM) were significantly decreased compared to baseline values in the 2 groups 1 day after the iohexol injection ( p < 0.05). A marked reduction in the D * values for both the CO and OM was also observed after 1 hour in each group ( p < 0.05). In the OM, a persistent elevation of the R2 * was detected for 4 days in the DCA group ( p < 0.05). Histopathological changes were prominent, and the pathological features of CI-AKI aggravated in the DCA group until day 4. The D, f, and R2 * values significantly correlated with the histological damage scores, hypoxia-inducible transcription factor-1α expression scores, and serum creatinine levels. Conclusion A combination of IVIM and BOLD imaging may serve as a noninvasive method for detecting and monitoring CI-AKI in the early stages in the diabetic kidney.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging

et al. 2019

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“…The tubular anatomy is radially arranged, resulting in anisotropic diffusion, which can be assessed by the DTI technique [13]. In kidney diseases such as chronic kidney disease, CI-AKI, and ischemia-reperfusion injury, both ADC and FA values are significantly reduced [4,7]. Moreover, BOLD-MRI, which can identify nephrotoxic drugs at an early stage, has been used to evaluate the effect of drugs on renal tissue oxygenation.…”

Section: Discussionmentioning

confidence: 99%

“…Its increasing result R2* value (transverse relaxation rate expressed as per second) indicates a higher deoxyhemoglobin concentration in renal tissue, meaning a lower oxygenation level and vice versa [6]. On the other hand, diffusion tensor imaging (DTI) that is based on the property of diffusion of water molecules in biological tissue has been increasingly used for the pathologies of nephropathy in clinic [4,7]. DTI analyzes tissue anisotropy by analyzing the diffusion of water in different directions, thus providing information on the apparent diffusion coefficient (ADC) and the degree of directed diffusion (fractional anisotropy, FA).…”

Section: Introductionmentioning

confidence: 99%

Application of diffusion tensor imaging and blood oxygenation level-dependent magnetic resonance imaging to assess bilateral renal function induced by Iohexol in rabbits

et al. 2020

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Background: Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) and diffusion tensor imaging (DTI) are useful methods for investigating the morphology and function of the kidneys, including revealing unilateral renal damage. Nevertheless, these techniques have not yet been applied for bilateral renal function. The aim of this study was to investigate whether the combination of DTI and BOLD could be used to examine different degrees of contrast-induced acute kidney injury (CI-AKI) in bilateral kidneys compared to standard methods such as serum creatinine (SCr) detection. Methods: Forty-Two New Zealand white rabbits were divided into two groups: the experimental group and the control group. Physiological saline and iodine contrast agent (iohexol, 1.0 g iodine/kg, 1.0 ml/sec) were injected via the right renal artery. DTI and BOLD-MR data were acquired longitudinally at the baseline and 1, 24, 48, and 72 h after high-pressure syringe injection to measure the apparent diffusion coefficient (ADC), fractional anisotropy (FA) and relative transverse relaxation rate (R2*). After the MR scan at each time point, three rabbits in each group were sacrificed, and changes in SCr and hypoxia-inducible factor-1α (HIF-1α) were analyzed using histopathology and immunochemistry. Results: Twenty-four hours after iohexol administration, the values of ADC and FA decreased significantly (P < 0.05), while R2* values increased (P < 0.05) in the renal cortex (CO), outer medulla (OM) and inner medulla (IM). Besides, significant negative correlations were observed among ADC, FA, and R2* in CO, OM, and IM (all P < 0.001, r = − 0.654-0.828). Conclusions: DTI and BOLD can simultaneously and non-invasively assess different degrees of CI-AKI in bilateral kidneys.

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“…54 BOLD MR studies of changes in renal medullary R2* suggest that the viscosity of radiocontrast may be more detrimental to renal oxygenation compared with osmolality. 55 Increases in kidney R2* with a marker of acute kidney injury (urinary neutrophil gelatinase-associated lipocalin) have been correlated in rodent models, and pretreatment with furosemide but not the antioxidant N-acetylcysteine significantly blunted the increase in medullary R2* in response to iodixanol suggesting a potential renoprotective effect. 56 Additional studies using BOLD in combination with other MR imaging techniques such as diffusion tensor imaging have suggested that contrast viscosity may have renal pathologic effects, and illustrate the flexibility and comprehensive capabilities of MR to assess renal pathophysiology.…”

Section: Contrast Nephropathymentioning

confidence: 99%

BOLD magnetic resonance imaging in nephrology

Hall¹,

Jordan²,

Juncos³

et al. 2018

IJNRD

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Magnetic resonance (MR) imaging, a non-invasive modality that provides anatomic and physiologic information, is increasingly used for diagnosis of pathophysiologic conditions and for understanding renal physiology in humans. Although functional MR imaging methods were pioneered to investigate the brain, they also offer powerful techniques for investigation of other organ systems such as the kidneys. However, imaging the kidneys provides unique challenges due to potential complications from contrast agents. Therefore, development of non-contrast techniques to study kidney anatomy and physiology is important. Blood oxygen level-dependent (BOLD) MR is a non-contrast imaging technique that provides functional information related to renal tissue oxygenation in various pathophysiologic conditions. Here we discuss technical considerations, clinical uses and future directions for use of BOLD MR as well as complementary MR techniques to better understand renal pathophysiology. Our intent is to summarize kidney BOLD MR applications for the clinician rather than focusing on the complex physical challenges that functional MR imaging encompasses; however, we briefly discuss some of those issues.

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Application of BOLD MRI and DTI for the evaluation of renal effect related to viscosity of iodinated contrast agent in a rat model

Abstract: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1320-1331.

Cited by 18 publications

References 32 publications

Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging

Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging

Application of diffusion tensor imaging and blood oxygenation level-dependent magnetic resonance imaging to assess bilateral renal function induced by Iohexol in rabbits

BOLD magnetic resonance imaging in nephrology

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