Application of cell membrane-functionalized biomimetic nanoparticles in the treatment of glioma

Zhang, Guangchuan; Yao, M.; Ma, Shenglin; Zhang, Kun; Wang, Yujue; Wang, Zhimin; Liang, Jiaheng; Dai, Shikun; Jin, Rui; Guan, Fangxia

doi:10.1039/d3tb00605k

Cited by 8 publications

(3 citation statements)

References 150 publications

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“…Over the past several years, diverse biomimetic nanocomposites have been developed for improved glioma chemotherapy. [28] For instance, Chai et al reported a biomimetic delivery system using modified red blood cell (RBC) membranes and docetaxelloaded nanocrystals (NCs) to achieve enhanced chemotherapy for glioma (Figure 4a). [29] The coating of RBC membranes can bestow nanocomposites with improved biocompatibility and prolonged circulation time, which is favorable for drug delivery.…”

Section: Chemotherapymentioning

confidence: 99%

“…However, achieving effective accumulation of chemotherapeutic drugs at glioma sites is difficult, due to the limited circulation time, non‐targeted delivery, and the hurdle of BBB, which reduce the anti‐glioma efficacy of these drugs. Over the past several years, diverse biomimetic nanocomposites have been developed for improved glioma chemotherapy [28] . For instance, Chai et al.…”

Section: Biomimetic Nanocomposites For Glioma Therapymentioning

confidence: 99%

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Biomimetic Nanocomposites for Glioma Imaging and Therapy

Chi,

Wang,

Liu

2024

Chemistry A European J

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Glioma, the most common primary brain tumor, is highly invasive and grows rapidly. As such, the survival of glioma patients is relatively short, highlighting the vital importance of timely diagnosis and treatment of glioma. However, the blood brain barrier (BBB) and the non‐targeting delivery systems of contrast agents and drugs greatly hinder the effective glioma imaging and therapy. Fortunately, in recent years, investigators have constructed various biomimetic delivery platforms utilizing the exceptional advantages of biomimetic nanocomposites, such as immune evasion, homologous targeting ability, and BBB penetrating ability, to achieve efficient and precise delivery of substances to glioma sites for improved diagnosis and treatment. In this concept, we present the application of these biomimetic nanocomposites in fluorescence imaging (FI), magnetic resonance imaging (MRI), and multi‐modal imaging, as well as in chemotherapy, phototherapy, and combined therapy for glioma. Lastly, we provide our perspective on this research field.

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Section: Chemotherapymentioning

confidence: 99%

Section: Biomimetic Nanocomposites For Glioma Therapymentioning

confidence: 99%

Biomimetic Nanocomposites for Glioma Imaging and Therapy

Chi,

Wang,

Liu

2024

Chemistry A European J

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“…Microviscosity of cell membranes ranks among the critical biophysical parameters of a cell, as alterations can lead to significant disruptions in morphology and physiology. Changes in membrane lipid metabolism are observed in various tumor types [ 18 , 19 ]. Cholesterol synthesis is impaired in tumor cells, with metastatic brain tumors, for instance, exhibiting elevated cholesterol levels.…”

Section: Problems Of Effective Drug Delivery and Therapy Of Brain Tumorsmentioning

confidence: 99%

Methods of miRNA delivery and possibilities of their application in neuro-oncology

Gareev,

Beylerli,

Tamrazov

et al. 2023

Non-coding RNA Research

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Engineered Cell Membrane‐Coated Nanoparticles: New Strategies in Glioma Targeted Therapy and Immune Modulation

Ma,

Yi,

Ruan

et al. 2024

Adv Healthcare Materials

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Gliomas, the most prevalent primary brain tumors, pose considerable challenges due to their heterogeneity, intricate tumor microenvironment (TME), and blood‐brain barrier (BBB), which restrict the effectiveness of traditional treatments like surgery and chemotherapy. This review provides an overview of engineered cell membrane technologies in glioma therapy, with a specific emphasis on targeted drug delivery and modulation of the immune microenvironment. This study investigates the progress in engineered cell membranes, encompassing physical, chemical, and genetic alterations, to improve drug delivery across the BBB and effectively target gliomas. The examination focuses on the interaction of engineered cell membrane‐coated nanoparticles (ECM‐NPs) with the TME in gliomas, emphasizing their potential to modulate glioma cell behavior and TME to enhance therapeutic efficacy. The review further explores the involvement of ECM‐NPs in immunomodulation techniques, highlighting their impact on immune reactions. While facing obstacles related to membrane stability and manufacturing scalability, the review outlines forthcoming research directions focused on enhancing membrane performance. This review underscores the promise of ECM‐NPs in surpassing conventional therapeutic constraints, proposing novel approaches for efficacious glioma treatment.This article is protected by copyright. All rights reserved

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Application of cell membrane-functionalized biomimetic nanoparticles in the treatment of glioma

Abstract: Glioma is one of the most common malignant tumors with the characteristics of strong invasion and high postoperative recurrence rate, which threatens the health of human seriously. Nanoparticles as an...

Cited by 8 publications

References 150 publications

Biomimetic Nanocomposites for Glioma Imaging and Therapy

Biomimetic Nanocomposites for Glioma Imaging and Therapy

Methods of miRNA delivery and possibilities of their application in neuro-oncology

Engineered Cell Membrane‐Coated Nanoparticles: New Strategies in Glioma Targeted Therapy and Immune Modulation

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