Application of cerium oxide nanoparticles as modificators in radiation therapy

Вазиров, Р. А.; Sokovnin, S. Yu.; Il’ves, Vladislav G.; Myshkina, A. V.; Бажукова, И. Н.

doi:10.1063/1.5055183

Cited by 6 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This differential action can result in the protection of normal cells while sensitizating of cancer cells. The most challenging part of this procedure is to protect normal cells from radiation 51 …”

Section: Discussionmentioning

confidence: 99%

Cerium oxide nanoparticles display antioxidant and antiapoptotic effects on gamma irradiation‐induced hepatotoxicity

Saif‐Elnasr,

Samy,

Abdel‐Khalek

2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

Throughout radiotherapy, radiation of the hepatic tissue leads to damage of the hepatocytes. We designed the current study to examine how cerium oxide nanoparticles (CONPs) modulate gamma irradiation‐induced hepatotoxicity in rats. Animals received CONPs (15 mg/kg body weight [BW], ip) single daily dose for 14 days, and they were exposed on the seventh day to a single dose of gamma radiation (6 Gy). Results showed that irradiation increased serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activities. Furthermore, it elevated oxidative stress biomarker; malondialdehyde (MDA) and inhibited the activities of antioxidant enzymes (superoxide dismutase and glutathione peroxidase) in hepatic tissues homogenate. Additionally, hepatic apoptotic markers; caspase‐3 (Casp‐3) and Casp‐9 were elevated and the B‐cell lymphoma‐2 (Bcl‐2) gene level was decreased in rats exposed to radiation dose. We observed that CONPs can modulate these changes, where CONPs reduced liver enzyme activities, MDA, and apoptotic markers levels, in addition, it elevated antioxidant enzyme activities and Bcl‐2 gene levels, as well as improved histopathological changes in the irradiated animals. So our results concluded that CONPs had the ability to act as radioprotector defense against hepatotoxicity resulted during radiotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Cerium oxide nanoparticles display antioxidant and antiapoptotic effects on gamma irradiation‐induced hepatotoxicity

Saif‐Elnasr,

Samy,

Abdel‐Khalek

2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

“…Вследствие наличия разновалентных форм Се 3+ /Се 4+ на поверхности наночастиц они проявляют уникальные окислительновосстановительные свойства, благодаря чему могут быть использованы для терапии различных хронических заболеваний, обусловленных окислительным стрессом кле-ток и тканей. В наших работах исследован антиоксидантный потенциал данных наночастиц [223][224][225]. Кроме того, были показаны низкая цитотоксичность СеО 2 и избирательное ингибирование опухолевых клеток наночастицами [47], что представляет значительный интерес для биомедицинских приложений.…”

Section: тераностика в последние годы значитель-unclassified

“…Помимо вышеупомянутых биомедицинских приложений, люминесцентные наночастицы могут в дальнейшем быть использованы для антиоксидантной терапии [222][223][224], радиотерапии [225], оптогенетики [4], нанотермометрии [227,228]. К сожалению, большинство из упомянутых направлений пока не использует люминесцентные наночастицы.…”

Section: тераностика в последние годы значитель-unclassified

Люминесцентные Наноматериалы, Допированные Редкоземельными Ионами, И Перспективы Их Биомедицинского Применения (Обзор)

Бажукова¹,

Пустоваров²,

Мышкина³

et al. 2020

Журнал Технической Физики

View full text Add to dashboard Cite

Luminescent nanomaterials doped with rare-earth elements are characterized by such physicochemical properties as long-lived luminescence, large Stokes or anti-Stokes shifts, narrow emission bands, high photostability and low toxicity. These materials can be considered as a new generation of biosensors along with conventional molecular probes, such as organic dyes, quantum dots and chelate-based lanthanide probes. In recent years there has been significant interest in the study of functional nanomaterials based on rare earth elements. The purpose of this paper is to provide an overview of recent advances in the development of luminescent inorganic nanoparticles doped with rare earth elements which could be used for biomedical applications.

show abstract

“…Our work also further advances therapeutic biomaterials based on nanocrystalline cerium oxide. Recently, it has been shown that nanocrystalline cerium oxide is a very promising nanomaterial for radioprotection of normal tissues [56][57][58][59][60][61] while its practical applications are considerably hindered by the absence of robust delivery systems. The use of polyelectrolyte microcapsules provides the means for a precisely dosed delivery of cerium oxide nanoparticles into the cell with their subsequent controlled release, as well as providing a pronounced therapeutic effect, which is confirmed by our current results.…”

Section: Introductionmentioning

confidence: 99%

Ceria-Containing Hybrid Multilayered Microcapsules for Enhanced Cellular Internalisation with High Radioprotection Efficiency

et al. 2020

View full text Add to dashboard Cite

Cerium oxide nanoparticles (nanoceria) are believed to be the most versatile nanozyme, showing great promise for biomedical applications. At the same time, the controlled intracellular delivery of nanoceria remains an unresolved problem. Here, we have demonstrated the radioprotective effect of polyelectrolyte microcapsules modified with cerium oxide nanoparticles, which provide controlled loading and intracellular release. The optimal (both safe and uptake efficient) concentrations of ceria-containing microcapsules for human mesenchymal stem cells range from 1:10 to 1:20 cell-to-capsules ratio. We have revealed the molecular mechanisms of nanoceria radioprotective action on mesenchymal stem cells by assessing the level of intracellular reactive oxygen species (ROS), as well as by a detailed 96-genes expression analysis, featuring genes responsible for oxidative stress, mitochondrial metabolism, apoptosis, inflammation etc. Hybrid ceria-containing microcapsules have been shown to provide an indirect genoprotective effect, reducing the number of cytogenetic damages in irradiated cells. These findings give new insight into cerium oxide nanoparticles’ protective action for living beings against ionising radiation.

show abstract

Application of cerium oxide nanoparticles as modificators in radiation therapy

Cited by 6 publications

References 9 publications

Cerium oxide nanoparticles display antioxidant and antiapoptotic effects on gamma irradiation‐induced hepatotoxicity

Cerium oxide nanoparticles display antioxidant and antiapoptotic effects on gamma irradiation‐induced hepatotoxicity

Люминесцентные Наноматериалы, Допированные Редкоземельными Ионами, И Перспективы Их Биомедицинского Применения (Обзор)

Ceria-Containing Hybrid Multilayered Microcapsules for Enhanced Cellular Internalisation with High Radioprotection Efficiency

Contact Info

Product

Resources

About